High plasma CXCL10 levels are associated with HCV-genotype 1, and higher insulin resistance, fibrosis, and HIV viral load in HIV/HCV coinfected patients

Background: CXCL10 may contribute to the host immune response against the hepatitis C virus (HCV), liver disease progression, and response to HCV antiviral therapy. The aim of our study was to analyze the relationship among virological, immunological, and clinical characteristics with plasma CXCL10...

Descripción completa

Detalles Bibliográficos
Autores: Berenguer, Juan, Fernandez-Rodriguez, Amanda, Jimenez-Sousa, Maria Angeles, Cosín, Jaime, Zarate, Paola, Micheloud, Dariela, López, Juan Carlos, Miralles, Pilar, Catalán, Pilar, Resino, Salvador
Tipo de recurso: artículo
Fecha de publicación:2012
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/17446
Acceso en línea:http://hdl.handle.net/20.500.12105/17446
Access Level:acceso abierto
Palabra clave:Insulin Resistance
Adult
Antiviral Agents
Biomarkers
Chemokine CXCL10
Coinfection
Disease Progression
Female
Genotype
HIV
Hepacivirus
Hepatitis C
Humans
Liver Cirrhosis
Male
Multivariate Analysis
Viral Load
id ES_ec7ebb0f82f1637b66ddfc78b8d07ea1
oai_identifier_str oai:repisalud.isciii.es:20.500.12105/17446
network_acronym_str ES
network_name_str España
repository_id_str
spelling High plasma CXCL10 levels are associated with HCV-genotype 1, and higher insulin resistance, fibrosis, and HIV viral load in HIV/HCV coinfected patientsBerenguer, JuanFernandez-Rodriguez, AmandaJimenez-Sousa, Maria AngelesCosín, JaimeZarate, PaolaMicheloud, DarielaLópez, Juan CarlosMiralles, PilarCatalán, PilarResino, SalvadorInsulin ResistanceAdultAntiviral AgentsBiomarkersChemokine CXCL10CoinfectionDisease ProgressionFemaleGenotypeHIVHepacivirusHepatitis CHumansLiver CirrhosisMaleMultivariate AnalysisViral LoadBackground: CXCL10 may contribute to the host immune response against the hepatitis C virus (HCV), liver disease progression, and response to HCV antiviral therapy. The aim of our study was to analyze the relationship among virological, immunological, and clinical characteristics with plasma CXCL10 levels in human immunodeficiency virus (HIV)/HCV-coinfected patients. Methods: We carried out a cross-sectional study on 144 patients. CXCL10 and insulin were measured using an immunoassay kit. The degree of insulin resistance was estimated for each patient using the homeostatic model assessment (HOMA) method. Insulin resistance was defined as a HOMA index higher than or equal to 3.8. Aspartate aminotransferase (AST) to platelet ratio (APRI), FIB-4, Forns index, HGM1, and HGM2 were calculated. Results: The variables associated with log(10) CXCL10 levels by univariate analysis were age (b=0.013; p=0.023), prior AIDS-defining condition (b=0.127; p=0.045), detectable plasma HIV viral load (b=0.092; p=0.006), log(10) HOMA (b=0.216; p=0.002), HCV-genotype 1 (b=0.114; p=0.071), and liver fibrosis assessed by all non-invasive indexes (log(10) APRI (b=0.296; p=0.001), log(10) FIB-4 (b=0.436; p<0.001), log(10) Forns index (b=0.591; p<0.001), log(10) HGM1 (b=0.351; p=0.021), and log(10) HGM2 (b=0.215; p=0.018)). However, in multivariate analysis, CXCL10 levels were only associated with HOMA, detectable plasma HIV viral load, HCV-genotype 1 and FIB-4 (R-square=0.235; p<0.001). Conclusion: Plasma CXCL10 levels were influenced by several characteristics of patients related to HIV and HCV infections, insulin resistance, and liver fibrosis, indicating that CXCL10 may play an important role in the pathogenesis of both HCV and HIV infections.ElsevierInstituto de Salud Carlos IIIRedes Temáticas de Investigación Cooperativa en Salud (RETICS) (España)Fundación para la Investigación y la Prevención del Sida en España20242024-02-0320122012-01-0120122012-01-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/17446reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/174462026-06-12T12:43:37Z
dc.title.none.fl_str_mv High plasma CXCL10 levels are associated with HCV-genotype 1, and higher insulin resistance, fibrosis, and HIV viral load in HIV/HCV coinfected patients
title High plasma CXCL10 levels are associated with HCV-genotype 1, and higher insulin resistance, fibrosis, and HIV viral load in HIV/HCV coinfected patients
spellingShingle High plasma CXCL10 levels are associated with HCV-genotype 1, and higher insulin resistance, fibrosis, and HIV viral load in HIV/HCV coinfected patients
Berenguer, Juan
Insulin Resistance
Adult
Antiviral Agents
Biomarkers
Chemokine CXCL10
Coinfection
Disease Progression
Female
Genotype
HIV
Hepacivirus
Hepatitis C
Humans
Liver Cirrhosis
Male
Multivariate Analysis
Viral Load
title_short High plasma CXCL10 levels are associated with HCV-genotype 1, and higher insulin resistance, fibrosis, and HIV viral load in HIV/HCV coinfected patients
title_full High plasma CXCL10 levels are associated with HCV-genotype 1, and higher insulin resistance, fibrosis, and HIV viral load in HIV/HCV coinfected patients
title_fullStr High plasma CXCL10 levels are associated with HCV-genotype 1, and higher insulin resistance, fibrosis, and HIV viral load in HIV/HCV coinfected patients
title_full_unstemmed High plasma CXCL10 levels are associated with HCV-genotype 1, and higher insulin resistance, fibrosis, and HIV viral load in HIV/HCV coinfected patients
title_sort High plasma CXCL10 levels are associated with HCV-genotype 1, and higher insulin resistance, fibrosis, and HIV viral load in HIV/HCV coinfected patients
dc.creator.none.fl_str_mv Berenguer, Juan
Fernandez-Rodriguez, Amanda
Jimenez-Sousa, Maria Angeles
Cosín, Jaime
Zarate, Paola
Micheloud, Dariela
López, Juan Carlos
Miralles, Pilar
Catalán, Pilar
Resino, Salvador
author Berenguer, Juan
author_facet Berenguer, Juan
Fernandez-Rodriguez, Amanda
Jimenez-Sousa, Maria Angeles
Cosín, Jaime
Zarate, Paola
Micheloud, Dariela
López, Juan Carlos
Miralles, Pilar
Catalán, Pilar
Resino, Salvador
author_role author
author2 Fernandez-Rodriguez, Amanda
Jimenez-Sousa, Maria Angeles
Cosín, Jaime
Zarate, Paola
Micheloud, Dariela
López, Juan Carlos
Miralles, Pilar
Catalán, Pilar
Resino, Salvador
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Salud Carlos III
Redes Temáticas de Investigación Cooperativa en Salud (RETICS) (España)
Fundación para la Investigación y la Prevención del Sida en España
dc.subject.none.fl_str_mv Insulin Resistance
Adult
Antiviral Agents
Biomarkers
Chemokine CXCL10
Coinfection
Disease Progression
Female
Genotype
HIV
Hepacivirus
Hepatitis C
Humans
Liver Cirrhosis
Male
Multivariate Analysis
Viral Load
topic Insulin Resistance
Adult
Antiviral Agents
Biomarkers
Chemokine CXCL10
Coinfection
Disease Progression
Female
Genotype
HIV
Hepacivirus
Hepatitis C
Humans
Liver Cirrhosis
Male
Multivariate Analysis
Viral Load
description Background: CXCL10 may contribute to the host immune response against the hepatitis C virus (HCV), liver disease progression, and response to HCV antiviral therapy. The aim of our study was to analyze the relationship among virological, immunological, and clinical characteristics with plasma CXCL10 levels in human immunodeficiency virus (HIV)/HCV-coinfected patients. Methods: We carried out a cross-sectional study on 144 patients. CXCL10 and insulin were measured using an immunoassay kit. The degree of insulin resistance was estimated for each patient using the homeostatic model assessment (HOMA) method. Insulin resistance was defined as a HOMA index higher than or equal to 3.8. Aspartate aminotransferase (AST) to platelet ratio (APRI), FIB-4, Forns index, HGM1, and HGM2 were calculated. Results: The variables associated with log(10) CXCL10 levels by univariate analysis were age (b=0.013; p=0.023), prior AIDS-defining condition (b=0.127; p=0.045), detectable plasma HIV viral load (b=0.092; p=0.006), log(10) HOMA (b=0.216; p=0.002), HCV-genotype 1 (b=0.114; p=0.071), and liver fibrosis assessed by all non-invasive indexes (log(10) APRI (b=0.296; p=0.001), log(10) FIB-4 (b=0.436; p<0.001), log(10) Forns index (b=0.591; p<0.001), log(10) HGM1 (b=0.351; p=0.021), and log(10) HGM2 (b=0.215; p=0.018)). However, in multivariate analysis, CXCL10 levels were only associated with HOMA, detectable plasma HIV viral load, HCV-genotype 1 and FIB-4 (R-square=0.235; p<0.001). Conclusion: Plasma CXCL10 levels were influenced by several characteristics of patients related to HIV and HCV infections, insulin resistance, and liver fibrosis, indicating that CXCL10 may play an important role in the pathogenesis of both HCV and HIV infections.
publishDate 2012
dc.date.none.fl_str_mv 2012
2012-01-01
2012
2012-01-01
2024
2024-02-03
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/17446
url http://hdl.handle.net/20.500.12105/17446
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869423319777804288
score 15,81155

Similares en LA Referencia