Duration of untreated negative and positive symptoms of psychosis and cognitive impairment in first episode psychosis

Background: Duration of untreated psychosis (DUP) has been significantly associated with poor clinical and social outcomes in First Episode Psychosis (FEP) patients, but an association with cognitive outcomes has not been clearly established. Method: Seventy-seven consecutively admitted, drug-naïve...

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Authors: Cuesta, Manuel J., García de Jalón, Elena, Campos, María S., Ibáñez, Berta, Sánchez Torres, Ana María, Peralta Martín, Víctor
Format: article
Status:Versión aceptada para publicación
Publication Date:2012
Country:España
Institution:Universidad Pública de Navarra
Repository:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
OAI Identifier:oai:academica-e.unavarra.es:2454/47216
Online Access:https://hdl.handle.net/2454/47216
Access Level:Open access
Keyword:Duration of untreated psychosis (DUP)
First episode psychosis
Longitudinal study
Cognition
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spelling Duration of untreated negative and positive symptoms of psychosis and cognitive impairment in first episode psychosisCuesta, Manuel J.García de Jalón, ElenaCampos, María S.Ibáñez, BertaSánchez Torres, Ana MaríaPeralta Martín, VíctorDuration of untreated psychosis (DUP)First episode psychosisLongitudinal studyCognitionBackground: Duration of untreated psychosis (DUP) has been significantly associated with poor clinical and social outcomes in First Episode Psychosis (FEP) patients, but an association with cognitive outcomes has not been clearly established. Method: Seventy-seven consecutively admitted, drug-naïve patients with FEP were assessed at baseline and at 1 month and 6 months. Underlying dimensions of DUP (general prodrome and positive, negative and disorganisation symptoms) were assessed using the Symptom Onset in Schizophrenia (SOS) inventory (Perkins et al., 2000). To assess the effect of DUP on the neuropsychological status of the patients, a linear mixed-effect model was fitted to each neuropsychological dimension. These models included a dichotomised version of DUP (short versus long duration) as a fixed effect, several adjusting variables to account for patient differences, and a random effect to incorporate the longitudinal structure of the data. Results: Patients with a short duration of untreated negative symptoms (DUNS) or a short duration of untreated positive symptoms (DUPS) outperformed patients with a long duration of untreated symptoms on memory tasks and a pre-attentional visual task but not on measures of verbal fluency, attention, reaction time, visual processing and executive functions. Conclusions: This study provides additional support for an early intervention to shorten DUP to facilitate a better outcome in memory and attentional domains of FEP patients.This work was supported by the Navarra government (grants 946/2005 and 55/2007), the ‘Fondo de Investigaciones Sanitarias’ from the Spanish Ministry of Health (grant PI081026) and the Spanish Ministry of Science and Innovation (grant SAF2008-05674-C03-02).ElsevierCiencias de la SaludOsasun ZientziakGobierno de Navarra / Nafarroako Gobernua2012info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2454/47216reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarrainstname:Universidad Pública de NavarraInglésinfo:eu-repo/grantAgreement/MICINN//SAF2008-05674-C03-02© 2012 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:academica-e.unavarra.es:2454/472162026-06-17T12:41:47Z
dc.title.none.fl_str_mv Duration of untreated negative and positive symptoms of psychosis and cognitive impairment in first episode psychosis
title Duration of untreated negative and positive symptoms of psychosis and cognitive impairment in first episode psychosis
spellingShingle Duration of untreated negative and positive symptoms of psychosis and cognitive impairment in first episode psychosis
Cuesta, Manuel J.
Duration of untreated psychosis (DUP)
First episode psychosis
Longitudinal study
Cognition
title_short Duration of untreated negative and positive symptoms of psychosis and cognitive impairment in first episode psychosis
title_full Duration of untreated negative and positive symptoms of psychosis and cognitive impairment in first episode psychosis
title_fullStr Duration of untreated negative and positive symptoms of psychosis and cognitive impairment in first episode psychosis
title_full_unstemmed Duration of untreated negative and positive symptoms of psychosis and cognitive impairment in first episode psychosis
title_sort Duration of untreated negative and positive symptoms of psychosis and cognitive impairment in first episode psychosis
dc.creator.none.fl_str_mv Cuesta, Manuel J.
García de Jalón, Elena
Campos, María S.
Ibáñez, Berta
Sánchez Torres, Ana María
Peralta Martín, Víctor
author Cuesta, Manuel J.
author_facet Cuesta, Manuel J.
García de Jalón, Elena
Campos, María S.
Ibáñez, Berta
Sánchez Torres, Ana María
Peralta Martín, Víctor
author_role author
author2 García de Jalón, Elena
Campos, María S.
Ibáñez, Berta
Sánchez Torres, Ana María
Peralta Martín, Víctor
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Ciencias de la Salud
Osasun Zientziak
Gobierno de Navarra / Nafarroako Gobernua
dc.subject.none.fl_str_mv Duration of untreated psychosis (DUP)
First episode psychosis
Longitudinal study
Cognition
topic Duration of untreated psychosis (DUP)
First episode psychosis
Longitudinal study
Cognition
description Background: Duration of untreated psychosis (DUP) has been significantly associated with poor clinical and social outcomes in First Episode Psychosis (FEP) patients, but an association with cognitive outcomes has not been clearly established. Method: Seventy-seven consecutively admitted, drug-naïve patients with FEP were assessed at baseline and at 1 month and 6 months. Underlying dimensions of DUP (general prodrome and positive, negative and disorganisation symptoms) were assessed using the Symptom Onset in Schizophrenia (SOS) inventory (Perkins et al., 2000). To assess the effect of DUP on the neuropsychological status of the patients, a linear mixed-effect model was fitted to each neuropsychological dimension. These models included a dichotomised version of DUP (short versus long duration) as a fixed effect, several adjusting variables to account for patient differences, and a random effect to incorporate the longitudinal structure of the data. Results: Patients with a short duration of untreated negative symptoms (DUNS) or a short duration of untreated positive symptoms (DUPS) outperformed patients with a long duration of untreated symptoms on memory tasks and a pre-attentional visual task but not on measures of verbal fluency, attention, reaction time, visual processing and executive functions. Conclusions: This study provides additional support for an early intervention to shorten DUP to facilitate a better outcome in memory and attentional domains of FEP patients.
publishDate 2012
dc.date.none.fl_str_mv 2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2454/47216
url https://hdl.handle.net/2454/47216
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/MICINN//SAF2008-05674-C03-02
dc.rights.none.fl_str_mv © 2012 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0.
https://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © 2012 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0.
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
instname:Universidad Pública de Navarra
instname_str Universidad Pública de Navarra
reponame_str Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
collection Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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