Global Real-World Evidence of Sofosbuvir/Velpatasvir as a Highly Effective Treatment and Elimination Tool in People with Hepatitis C Infection Experiencing Mental Health Disorders

HCV elimination; Mental health disorders; Sofosbuvir/velpatasvir

Bibliographic Details
Authors: Di Marco, Vito, Garcia-Retortillo, Montserrat, Teti, Elisabetta, Fraser, Chris, Buti Ferret, Maria, Morano Amado, Luis Enrique, Wedemeyer, Heiner
Format: article
Status:Published version
Publication Date:2022
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:11351/8597
Online Access:https://hdl.handle.net/11351/8597
http://hdl.handle.net/11351/8597
Access Level:Open access
Keyword:Hepatitis C - Tractament
Medicaments antivírics - Ús terapèutic
Malalties mentals
DISEASES::Virus Diseases::Hepatitis, Viral, Human::Hepatitis C
Other subheadings::Other subheadings::Other subheadings::/drug therapy
PSYCHIATRY AND PSYCHOLOGY::Mental Disorders
CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Antiviral Agents
Other subheadings::Other subheadings::/therapeutic use
ENFERMEDADES::virosis::hepatitis viral humana::hepatitis C
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales
COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antiinfecciosos::antivíricos
Otros calificadores::Otros calificadores::/uso terapéutico
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oai_identifier_str oai:recercat.cat:11351/8597
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Global Real-World Evidence of Sofosbuvir/Velpatasvir as a Highly Effective Treatment and Elimination Tool in People with Hepatitis C Infection Experiencing Mental Health Disorders
title Global Real-World Evidence of Sofosbuvir/Velpatasvir as a Highly Effective Treatment and Elimination Tool in People with Hepatitis C Infection Experiencing Mental Health Disorders
spellingShingle Global Real-World Evidence of Sofosbuvir/Velpatasvir as a Highly Effective Treatment and Elimination Tool in People with Hepatitis C Infection Experiencing Mental Health Disorders
Di Marco, Vito
Hepatitis C - Tractament
Medicaments antivírics - Ús terapèutic
Malalties mentals
DISEASES::Virus Diseases::Hepatitis, Viral, Human::Hepatitis C
Other subheadings::Other subheadings::Other subheadings::/drug therapy
PSYCHIATRY AND PSYCHOLOGY::Mental Disorders
CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Antiviral Agents
Other subheadings::Other subheadings::/therapeutic use
ENFERMEDADES::virosis::hepatitis viral humana::hepatitis C
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales
COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antiinfecciosos::antivíricos
Otros calificadores::Otros calificadores::/uso terapéutico
title_short Global Real-World Evidence of Sofosbuvir/Velpatasvir as a Highly Effective Treatment and Elimination Tool in People with Hepatitis C Infection Experiencing Mental Health Disorders
title_full Global Real-World Evidence of Sofosbuvir/Velpatasvir as a Highly Effective Treatment and Elimination Tool in People with Hepatitis C Infection Experiencing Mental Health Disorders
title_fullStr Global Real-World Evidence of Sofosbuvir/Velpatasvir as a Highly Effective Treatment and Elimination Tool in People with Hepatitis C Infection Experiencing Mental Health Disorders
title_full_unstemmed Global Real-World Evidence of Sofosbuvir/Velpatasvir as a Highly Effective Treatment and Elimination Tool in People with Hepatitis C Infection Experiencing Mental Health Disorders
title_sort Global Real-World Evidence of Sofosbuvir/Velpatasvir as a Highly Effective Treatment and Elimination Tool in People with Hepatitis C Infection Experiencing Mental Health Disorders
dc.creator.none.fl_str_mv Di Marco, Vito
Garcia-Retortillo, Montserrat
Teti, Elisabetta
Fraser, Chris
Buti Ferret, Maria
Morano Amado, Luis Enrique
Wedemeyer, Heiner
author Di Marco, Vito
author_facet Di Marco, Vito
Garcia-Retortillo, Montserrat
Teti, Elisabetta
Fraser, Chris
Buti Ferret, Maria
Morano Amado, Luis Enrique
Wedemeyer, Heiner
author_role author
author2 Garcia-Retortillo, Montserrat
Teti, Elisabetta
Fraser, Chris
Buti Ferret, Maria
Morano Amado, Luis Enrique
Wedemeyer, Heiner
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Wedemeyer H] Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany. [Di Marco V] University of Palermo, Palermo, Italy. [Garcia-Retortillo M] Liver Section, Gastroenterology Department, Hospital del Mar-Parc de Salut Mar, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain. [Teti E] Tor Vergata University, Rome, Italy. [Fraser C] Cool Aid Community Health Centre, Canada. [Morano Amado LE] Unit of Infectious Diseases, Álvaro Cunqueiro University Hospital, Vigo, Spain. [Buti M] Unitat Hepàtica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. CIBEREHD del Instituto Carlos III, Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Hepatitis C - Tractament
Medicaments antivírics - Ús terapèutic
Malalties mentals
DISEASES::Virus Diseases::Hepatitis, Viral, Human::Hepatitis C
Other subheadings::Other subheadings::Other subheadings::/drug therapy
PSYCHIATRY AND PSYCHOLOGY::Mental Disorders
CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Antiviral Agents
Other subheadings::Other subheadings::/therapeutic use
ENFERMEDADES::virosis::hepatitis viral humana::hepatitis C
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales
COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antiinfecciosos::antivíricos
Otros calificadores::Otros calificadores::/uso terapéutico
topic Hepatitis C - Tractament
Medicaments antivírics - Ús terapèutic
Malalties mentals
DISEASES::Virus Diseases::Hepatitis, Viral, Human::Hepatitis C
Other subheadings::Other subheadings::Other subheadings::/drug therapy
PSYCHIATRY AND PSYCHOLOGY::Mental Disorders
CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Antiviral Agents
Other subheadings::Other subheadings::/therapeutic use
ENFERMEDADES::virosis::hepatitis viral humana::hepatitis C
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales
COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antiinfecciosos::antivíricos
Otros calificadores::Otros calificadores::/uso terapéutico
description HCV elimination; Mental health disorders; Sofosbuvir/velpatasvir
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/8597
http://hdl.handle.net/11351/8597
url https://hdl.handle.net/11351/8597
http://hdl.handle.net/11351/8597
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Viruses;14(11)
https://doi.org/10.3390/v14112493
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Scientia
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869423275125243904
spelling Global Real-World Evidence of Sofosbuvir/Velpatasvir as a Highly Effective Treatment and Elimination Tool in People with Hepatitis C Infection Experiencing Mental Health DisordersDi Marco, VitoGarcia-Retortillo, MontserratTeti, ElisabettaFraser, ChrisButi Ferret, MariaMorano Amado, Luis EnriqueWedemeyer, HeinerHepatitis C - TractamentMedicaments antivírics - Ús terapèuticMalalties mentalsDISEASES::Virus Diseases::Hepatitis, Viral, Human::Hepatitis COther subheadings::Other subheadings::Other subheadings::/drug therapyPSYCHIATRY AND PSYCHOLOGY::Mental DisordersCHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Antiviral AgentsOther subheadings::Other subheadings::/therapeutic useENFERMEDADES::virosis::hepatitis viral humana::hepatitis COtros calificadores::Otros calificadores::Otros calificadores::/farmacoterapiaPSIQUIATRÍA Y PSICOLOGÍA::trastornos mentalesCOMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antiinfecciosos::antivíricosOtros calificadores::Otros calificadores::/uso terapéuticoHCV elimination; Mental health disorders; Sofosbuvir/velpatasvirEliminación del VHC; Trastornos de salud mental; Sofosbuvir/velpatasvirEliminació del VHC; Trastorns de salut mental; Sofosbuvir/velpatasvirHepatitis C virus (HCV) is prevalent in people with mental health disorders, a priority population to diagnose and cure in order to achieve HCV elimination. This integrated analysis pooled data from 20 cohorts in seven countries to evaluate the real-world effectiveness of the pangenotypic direct-acting antiviral (DAA) sofosbuvir/velpatasvir (SOF/VEL) in people with mental health disorders. HCV-infected patients diagnosed with mental health disorders who were treated with SOF/VEL for 12 weeks without ribavirin as part of routine clinical practice were included. The primary outcome was sustained virological response (SVR) in the effectiveness population (EP), defined as patients with an available SVR assessment. Secondary outcomes were reasons for not achieving SVR, characteristics of patients with non-virological failures, adherence, and time from HCV RNA diagnosis to SOF/VEL treatment initiation. A total of 1209 patients were included; 142 did not achieve an SVR for non-virological reasons (n = 112; 83 lost to follow-up, 20 early treatment discontinuations) or unknown reasons (n = 30). Of the 1067 patients in the EP, 97.4% achieved SVR. SVR rates in the EP were ≥95% when stratified by type of mental health disorder and other complicating baseline characteristics, including active injection drug use and antipsychotic drug use. Of 461 patients with data available in the EP, only 2% had an adherence level < 90% and 1% had an adherence level < 80%; all achieved SVR. Patients with mental health disorders can be cured of HCV using a well-tolerated, pangenotypic, protease inhibitor-free SOF/VEL regimen. This DAA allows the implementation of a simple treatment algorithm, with minimal monitoring requirements and fewer interactions with central nervous system drugs compared with protease-inhibitor DAA regimens.Article processing charges, statistical support and medical writing assistance were funded by Gilead Sciences Ltd.MDPIInstitut Català de la Salut[Wedemeyer H] Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany. [Di Marco V] University of Palermo, Palermo, Italy. [Garcia-Retortillo M] Liver Section, Gastroenterology Department, Hospital del Mar-Parc de Salut Mar, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain. [Teti E] Tor Vergata University, Rome, Italy. [Fraser C] Cool Aid Community Health Centre, Canada. [Morano Amado LE] Unit of Infectious Diseases, Álvaro Cunqueiro University Hospital, Vigo, Spain. [Buti M] Unitat Hepàtica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. CIBEREHD del Instituto Carlos III, Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/8597http://hdl.handle.net/11351/8597Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésViruses;14(11)https://doi.org/10.3390/v14112493Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/85972026-05-29T05:05:01Z
score 15,198674

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