The vitamin D decrease in children with obesity is associated with the development of insulin resistance during puberty: The PUBMEP study

Obesity and cardiometabolic risk have been associated with vitamin D levels even in children. The objective of the present study was to evaluate the association between insulin resistance (IR), cardiometabolic risk factors, and vitamin D in children from prepubertal to pubertal stages. A total of 76...

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Autores: Pires L.V., González-Gil E.M., Anguita-Ruiz A., Bueno G., Gil-Campos M., Vázquez-Cobela R., Pérez-Ferreirós A., Moreno L.A., Gil Á., Leis R., Aguilera C.M.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universidad de Zaragoza
Repositorio:Zaguán. Repositorio Digital de la Universidad de Zaragoza
OAI Identifier:oai:zaguan.unizar.es:117370
Acceso en línea:http://zaguan.unizar.es/record/117370
Access Level:acceso abierto
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spelling The vitamin D decrease in children with obesity is associated with the development of insulin resistance during puberty: The PUBMEP studyPires L.V.González-Gil E.M.Anguita-Ruiz A.Bueno G.Gil-Campos M.Vázquez-Cobela R.Pérez-Ferreirós A.Moreno L.A.Gil Á.Leis R.Aguilera C.M.Obesity and cardiometabolic risk have been associated with vitamin D levels even in children. The objective of the present study was to evaluate the association between insulin resistance (IR), cardiometabolic risk factors, and vitamin D in children from prepubertal to pubertal stages. A total of 76 children from the PUBMEP study, aged 4–12 years at baseline, were included. Children were evaluated in prepubertal and pubertal stages. Anthropometric measurements and selected cardiometabolic risk biomarkers, such as plasma glucose, blood lipids, insulin, adiponectin, leptin, and blood pressure, and serum 25-hydroxyvitamin D (25(OH)D) were determined. Children were categorized by obesity degree and IR status combined before and after puberty. Paired t-test and multivariate linear regression analyses were conducted. During puberty, the increase in triacylglycerols, insulin, and HOMA-IR and the decrease in QUICKI were significantly associated with the reduction in 25(OH)D (B = -0.274, p = 0.032; B = -0.219, p = 0.019; B = -0.250, p = 0.013; B = 1.574, p = 0.013, respectively) after adjustment by BMI-z, sex, and pubertal stage. Otherwise, prepubertal non-IR children with overweight/obesity that became IR during puberty showed a significant decrease in 25(OH)D and HDL-c, and an increase in waist circumference and triacylglycerol concentrations (p < 0.05 for all) over time. These results suggest that changes in IR seem to be associated with an effect on 25(OH)D levels during puberty, especially in children with overweight. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://zaguan.unizar.es/record/117370reponame:Zaguán. Repositorio Digital de la Universidad de Zaragozainstname:Universidad de ZaragozaInglésinfo:eu-repo/grantAgreement/ES/CIBERObn/CB15-00043info:eu-repo/grantAgreement/ES/CIBERObn/CB15-00131info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI11-01425info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI11-02042info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI11-02059info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI16-00871info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI16-01205info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI16-01301info:eu-repo/grantAgreement/ES/ISCIII/FISinfo:eu-repo/grantAgreement/ES/ISCIII/i-PFIS-IFI17-00048info:eu-repo/grantAgreement/ES/ISCIII/RETICS-RD12-0026-0015info:eu-repo/grantAgreement/ES/MINECO/FJCI-2017-34967info:eu-repo/semantics/openAccessoai:zaguan.unizar.es:1173702026-05-29T13:59:51Z
dc.title.none.fl_str_mv The vitamin D decrease in children with obesity is associated with the development of insulin resistance during puberty: The PUBMEP study
title The vitamin D decrease in children with obesity is associated with the development of insulin resistance during puberty: The PUBMEP study
spellingShingle The vitamin D decrease in children with obesity is associated with the development of insulin resistance during puberty: The PUBMEP study
Pires L.V.
title_short The vitamin D decrease in children with obesity is associated with the development of insulin resistance during puberty: The PUBMEP study
title_full The vitamin D decrease in children with obesity is associated with the development of insulin resistance during puberty: The PUBMEP study
title_fullStr The vitamin D decrease in children with obesity is associated with the development of insulin resistance during puberty: The PUBMEP study
title_full_unstemmed The vitamin D decrease in children with obesity is associated with the development of insulin resistance during puberty: The PUBMEP study
title_sort The vitamin D decrease in children with obesity is associated with the development of insulin resistance during puberty: The PUBMEP study
dc.creator.none.fl_str_mv Pires L.V.
González-Gil E.M.
Anguita-Ruiz A.
Bueno G.
Gil-Campos M.
Vázquez-Cobela R.
Pérez-Ferreirós A.
Moreno L.A.
Gil Á.
Leis R.
Aguilera C.M.
author Pires L.V.
author_facet Pires L.V.
González-Gil E.M.
Anguita-Ruiz A.
Bueno G.
Gil-Campos M.
Vázquez-Cobela R.
Pérez-Ferreirós A.
Moreno L.A.
Gil Á.
Leis R.
Aguilera C.M.
author_role author
author2 González-Gil E.M.
Anguita-Ruiz A.
Bueno G.
Gil-Campos M.
Vázquez-Cobela R.
Pérez-Ferreirós A.
Moreno L.A.
Gil Á.
Leis R.
Aguilera C.M.
author2_role author
author
author
author
author
author
author
author
author
author
description Obesity and cardiometabolic risk have been associated with vitamin D levels even in children. The objective of the present study was to evaluate the association between insulin resistance (IR), cardiometabolic risk factors, and vitamin D in children from prepubertal to pubertal stages. A total of 76 children from the PUBMEP study, aged 4–12 years at baseline, were included. Children were evaluated in prepubertal and pubertal stages. Anthropometric measurements and selected cardiometabolic risk biomarkers, such as plasma glucose, blood lipids, insulin, adiponectin, leptin, and blood pressure, and serum 25-hydroxyvitamin D (25(OH)D) were determined. Children were categorized by obesity degree and IR status combined before and after puberty. Paired t-test and multivariate linear regression analyses were conducted. During puberty, the increase in triacylglycerols, insulin, and HOMA-IR and the decrease in QUICKI were significantly associated with the reduction in 25(OH)D (B = -0.274, p = 0.032; B = -0.219, p = 0.019; B = -0.250, p = 0.013; B = 1.574, p = 0.013, respectively) after adjustment by BMI-z, sex, and pubertal stage. Otherwise, prepubertal non-IR children with overweight/obesity that became IR during puberty showed a significant decrease in 25(OH)D and HDL-c, and an increase in waist circumference and triacylglycerol concentrations (p < 0.05 for all) over time. These results suggest that changes in IR seem to be associated with an effect on 25(OH)D levels during puberty, especially in children with overweight. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
publishDate 2021
dc.date.none.fl_str_mv 2021
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info:eu-repo/semantics/publishedVersion
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dc.identifier.none.fl_str_mv http://zaguan.unizar.es/record/117370
url http://zaguan.unizar.es/record/117370
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
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info:eu-repo/grantAgreement/ES/ISCIII/i-PFIS-IFI17-00048
info:eu-repo/grantAgreement/ES/ISCIII/RETICS-RD12-0026-0015
info:eu-repo/grantAgreement/ES/MINECO/FJCI-2017-34967
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