Pharmacokinetics of PEGylated Gold Nanoparticles: In Vitro-In Vivo Correlation

Gold nanoparticles; Human cell lines; Pharmacokinetics

Detalhes bibliográficos
Autores: Dubaj, Tibor, Kozics, Katarina, Sramkova, Monika, Manova, Alena, Bastús, Neus G, Moriones, Oscar Hernando, Franco Puntes, Victor
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2022
País:España
Recursos:Departament de Salut de la Generalitat de Catalunya (DS)
Repositório:Scientia. Dipòsit d'Informació Digital del Departament de Salut
OAI Identifier:oai:scientiasalut.gencat.cat:11351/8820
Acesso em linha:https://hdl.handle.net/11351/8820
Access Level:Acceso aberto
Palavra-chave:Nanopartícules
Farmacocinètica
TECHNOLOGY, INDUSTRY, AND AGRICULTURE::Technology, Industry, and Agriculture::Manufactured Materials::Nanostructures::Nanoparticles::Metal Nanoparticles
PHENOMENA AND PROCESSES::Physiological Phenomena::Pharmacological and Toxicological Phenomena::Pharmacokinetics
TECNOLOGÍA, INDUSTRIA Y AGRICULTURA::tecnología, industria y agricultura::productos manufacturados::nanoestructuras::nanopartículas::nanopartículas metálicas
FENÓMENOS Y PROCESOS::fenómenos fisiológicos::fenómenos farmacológicos y toxicológicos::farmacocinética
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repository_id_str
spelling Pharmacokinetics of PEGylated Gold Nanoparticles: In Vitro-In Vivo CorrelationDubaj, TiborKozics, KatarinaSramkova, MonikaManova, AlenaBastús, Neus GMoriones, Oscar HernandoFranco Puntes, VictorNanopartículesFarmacocinèticaTECHNOLOGY, INDUSTRY, AND AGRICULTURE::Technology, Industry, and Agriculture::Manufactured Materials::Nanostructures::Nanoparticles::Metal NanoparticlesPHENOMENA AND PROCESSES::Physiological Phenomena::Pharmacological and Toxicological Phenomena::PharmacokineticsTECNOLOGÍA, INDUSTRIA Y AGRICULTURA::tecnología, industria y agricultura::productos manufacturados::nanoestructuras::nanopartículas::nanopartículas metálicasFENÓMENOS Y PROCESOS::fenómenos fisiológicos::fenómenos farmacológicos y toxicológicos::farmacocinéticaGold nanoparticles; Human cell lines; PharmacokineticsNanopartícules d'or; Línies cel·lulars humanes; FarmacocinèticaNanopartículas de oro; Líneas celulares humanas; FarmacocinéticaData suitable for assembling a physiologically-based pharmacokinetic (PBPK) model for nanoparticles (NPs) remain relatively scarce. Therefore, there is a trend in extrapolating the results of in vitro and in silico studies to in vivo nanoparticle hazard and risk assessment. To evaluate the reliability of such approach, a pharmacokinetic study was performed using the same polyethylene glycol-coated gold nanoparticles (PEG-AuNPs) in vitro and in vivo. As in vitro models, human cell lines TH1, A549, Hep G2, and 16HBE were employed. The in vivo PEG-AuNP biodistribution was assessed in rats. The internalization and exclusion of PEG-AuNPs in vitro were modeled as first-order rate processes with the partition coefficient describing the equilibrium distribution. The pharmacokinetic parameters were obtained by fitting the model to the in vitro data and subsequently used for PBPK simulation in vivo. Notable differences were observed in the internalized amount of Au in individual cell lines compared to the corresponding tissues in vivo, with the highest found for renal TH1 cells and kidneys. The main reason for these discrepancies is the absence of natural barriers in the in vitro conditions. Therefore, caution should be exercised when extrapolating in vitro data to predict the in vivo NP burden and response to exposure.This research was funded by the European Commission under the Horizon 2020 programme (HISENTS, Grant Agreement No. 685817 and VISION, Grant Agreement No. 857381). Financial support from the Structural Funds of EU by implementation of the project “Strategic research in SMART monitoring, treatment, and prevention against coronavirus (SARS-CoV-2)”, ITMS 2014+ code NFP313011ASS8 co-financed by the European Regional Development Fund.MDPIInstitut Català de la Salut[Dubaj T, Manova A] Institute of Physical Chemistry and Chemical Physics, Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava, Bratislava, Slovakia. [Kozics K, Sramkova M] Cancer Research Institute, Biomedical Research Center SAS, v.v.i., Bratislava, Slovakia. [Bastús NG, Moriones OH] Campus UAB, Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST, Bellaterra, Spain. [Puntes V] Campus UAB, Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST, Bellaterra, Spain. Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202320232022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/8820Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésNanomaterials;12(3)https://doi.org/10.3390/nano12030511info:eu-repo/grantAgreement/EC/H2020/685817info:eu-repo/grantAgreement/EC/H2020/857381Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/88202026-06-12T09:38:37Z
dc.title.none.fl_str_mv Pharmacokinetics of PEGylated Gold Nanoparticles: In Vitro-In Vivo Correlation
title Pharmacokinetics of PEGylated Gold Nanoparticles: In Vitro-In Vivo Correlation
spellingShingle Pharmacokinetics of PEGylated Gold Nanoparticles: In Vitro-In Vivo Correlation
Dubaj, Tibor
Nanopartícules
Farmacocinètica
TECHNOLOGY, INDUSTRY, AND AGRICULTURE::Technology, Industry, and Agriculture::Manufactured Materials::Nanostructures::Nanoparticles::Metal Nanoparticles
PHENOMENA AND PROCESSES::Physiological Phenomena::Pharmacological and Toxicological Phenomena::Pharmacokinetics
TECNOLOGÍA, INDUSTRIA Y AGRICULTURA::tecnología, industria y agricultura::productos manufacturados::nanoestructuras::nanopartículas::nanopartículas metálicas
FENÓMENOS Y PROCESOS::fenómenos fisiológicos::fenómenos farmacológicos y toxicológicos::farmacocinética
title_short Pharmacokinetics of PEGylated Gold Nanoparticles: In Vitro-In Vivo Correlation
title_full Pharmacokinetics of PEGylated Gold Nanoparticles: In Vitro-In Vivo Correlation
title_fullStr Pharmacokinetics of PEGylated Gold Nanoparticles: In Vitro-In Vivo Correlation
title_full_unstemmed Pharmacokinetics of PEGylated Gold Nanoparticles: In Vitro-In Vivo Correlation
title_sort Pharmacokinetics of PEGylated Gold Nanoparticles: In Vitro-In Vivo Correlation
dc.creator.none.fl_str_mv Dubaj, Tibor
Kozics, Katarina
Sramkova, Monika
Manova, Alena
Bastús, Neus G
Moriones, Oscar Hernando
Franco Puntes, Victor
author Dubaj, Tibor
author_facet Dubaj, Tibor
Kozics, Katarina
Sramkova, Monika
Manova, Alena
Bastús, Neus G
Moriones, Oscar Hernando
Franco Puntes, Victor
author_role author
author2 Kozics, Katarina
Sramkova, Monika
Manova, Alena
Bastús, Neus G
Moriones, Oscar Hernando
Franco Puntes, Victor
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Dubaj T, Manova A] Institute of Physical Chemistry and Chemical Physics, Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava, Bratislava, Slovakia. [Kozics K, Sramkova M] Cancer Research Institute, Biomedical Research Center SAS, v.v.i., Bratislava, Slovakia. [Bastús NG, Moriones OH] Campus UAB, Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST, Bellaterra, Spain. [Puntes V] Campus UAB, Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST, Bellaterra, Spain. Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Nanopartícules
Farmacocinètica
TECHNOLOGY, INDUSTRY, AND AGRICULTURE::Technology, Industry, and Agriculture::Manufactured Materials::Nanostructures::Nanoparticles::Metal Nanoparticles
PHENOMENA AND PROCESSES::Physiological Phenomena::Pharmacological and Toxicological Phenomena::Pharmacokinetics
TECNOLOGÍA, INDUSTRIA Y AGRICULTURA::tecnología, industria y agricultura::productos manufacturados::nanoestructuras::nanopartículas::nanopartículas metálicas
FENÓMENOS Y PROCESOS::fenómenos fisiológicos::fenómenos farmacológicos y toxicológicos::farmacocinética
topic Nanopartícules
Farmacocinètica
TECHNOLOGY, INDUSTRY, AND AGRICULTURE::Technology, Industry, and Agriculture::Manufactured Materials::Nanostructures::Nanoparticles::Metal Nanoparticles
PHENOMENA AND PROCESSES::Physiological Phenomena::Pharmacological and Toxicological Phenomena::Pharmacokinetics
TECNOLOGÍA, INDUSTRIA Y AGRICULTURA::tecnología, industria y agricultura::productos manufacturados::nanoestructuras::nanopartículas::nanopartículas metálicas
FENÓMENOS Y PROCESOS::fenómenos fisiológicos::fenómenos farmacológicos y toxicológicos::farmacocinética
description Gold nanoparticles; Human cell lines; Pharmacokinetics
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/8820
url https://hdl.handle.net/11351/8820
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Nanomaterials;12(3)
https://doi.org/10.3390/nano12030511
info:eu-repo/grantAgreement/EC/H2020/685817
info:eu-repo/grantAgreement/EC/H2020/857381
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Scientia
reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname:Departament de Salut de la Generalitat de Catalunya (DS)
instname_str Departament de Salut de la Generalitat de Catalunya (DS)
reponame_str Scientia. Dipòsit d'Informació Digital del Departament de Salut
collection Scientia. Dipòsit d'Informació Digital del Departament de Salut
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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