Neurotoxicity Induced by Oxidative Stress and Aluminium in Relation to Parkinson’s Disease: A Mitochondrial Bioenergetic Approach by High‐Resolution Respirometry

The study of mitochondria during the last years has revealed that this organelle plays an important role in the development and onset of neurodegenerative disorders such as Parkinson’s disease. The main hallmarks found in post‐mortem studies remark the importance of brain free radicals levels, the a...

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Detalles Bibliográficos
Autor: Iglesias González, Javier
Tipo de recurso: tesis doctoral
Fecha de publicación:2014
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/11435
Acceso en línea:http://hdl.handle.net/10347/11435
Access Level:acceso abierto
Palabra clave:Materias::Investigación::32 Ciencias médicas::3299 otras especialidades medicas (especificar)
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spelling Neurotoxicity Induced by Oxidative Stress and Aluminium in Relation to Parkinson’s Disease: A Mitochondrial Bioenergetic Approach by High‐Resolution RespirometryIglesias González, JavierMaterias::Investigación::32 Ciencias médicas::3299 otras especialidades medicas (especificar)The study of mitochondria during the last years has revealed that this organelle plays an important role in the development and onset of neurodegenerative disorders such as Parkinson’s disease. The main hallmarks found in post‐mortem studies remark the importance of brain free radicals levels, the alteration in brain metabolic parameters and the presence of xenobiotics like metals for the neurodegenerative processes. Also, any energetic deficit related with the metabolic impairment due to an exposition to toxics or an increase in oxidative stress might be a favorable condition for the onset of Parkinson’s disease. Within this framework, and in order to gain insight in the aetiology of Parkinson’s disease, this Thesis was developed as a bioenergetics study focused to oxidative stress, Parkinson’s disease, and aluminium.Soto-Otero, RamónMéndez Álvarez, EstefaníaUniversidade de Santiago de Compostela. Facultade de Medicina e Odontoloxía. Departamento de Bioquímica e Bioloxía Molecular20142014-09-0320142014-09-03doctoral thesishttp://purl.org/coar/resource_type/c_db06info:eu-repo/semantics/doctoralThesisapplication/pdfhttp://hdl.handle.net/10347/11435reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Esta obra atópase baixo unha licenza internacional Creative Commons BY-NC-ND 4.0. Calquera forma de reprodución, distribución, comunicación pública ou transformación desta obra non incluída na licenza Creative Commons BY-NC-ND 4.0 só pode ser realizada coa autorización expresa dos titulares, salvo excepción prevista pola lei. Pode acceder Vde. ao texto completo da licenza nesta ligazón: https://creativecommons.org/licenses/by-nc-nd/4.0/deed.glhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.glinfo:eu-repo/semantics/openAccessoai:minerva.usc.gal:10347/114352026-06-15T12:47:27Z
dc.title.none.fl_str_mv Neurotoxicity Induced by Oxidative Stress and Aluminium in Relation to Parkinson’s Disease: A Mitochondrial Bioenergetic Approach by High‐Resolution Respirometry
title Neurotoxicity Induced by Oxidative Stress and Aluminium in Relation to Parkinson’s Disease: A Mitochondrial Bioenergetic Approach by High‐Resolution Respirometry
spellingShingle Neurotoxicity Induced by Oxidative Stress and Aluminium in Relation to Parkinson’s Disease: A Mitochondrial Bioenergetic Approach by High‐Resolution Respirometry
Iglesias González, Javier
Materias::Investigación::32 Ciencias médicas::3299 otras especialidades medicas (especificar)
title_short Neurotoxicity Induced by Oxidative Stress and Aluminium in Relation to Parkinson’s Disease: A Mitochondrial Bioenergetic Approach by High‐Resolution Respirometry
title_full Neurotoxicity Induced by Oxidative Stress and Aluminium in Relation to Parkinson’s Disease: A Mitochondrial Bioenergetic Approach by High‐Resolution Respirometry
title_fullStr Neurotoxicity Induced by Oxidative Stress and Aluminium in Relation to Parkinson’s Disease: A Mitochondrial Bioenergetic Approach by High‐Resolution Respirometry
title_full_unstemmed Neurotoxicity Induced by Oxidative Stress and Aluminium in Relation to Parkinson’s Disease: A Mitochondrial Bioenergetic Approach by High‐Resolution Respirometry
title_sort Neurotoxicity Induced by Oxidative Stress and Aluminium in Relation to Parkinson’s Disease: A Mitochondrial Bioenergetic Approach by High‐Resolution Respirometry
dc.creator.none.fl_str_mv Iglesias González, Javier
author Iglesias González, Javier
author_facet Iglesias González, Javier
author_role author
dc.contributor.none.fl_str_mv Soto-Otero, Ramón
Méndez Álvarez, Estefanía
Universidade de Santiago de Compostela. Facultade de Medicina e Odontoloxía. Departamento de Bioquímica e Bioloxía Molecular
dc.subject.none.fl_str_mv Materias::Investigación::32 Ciencias médicas::3299 otras especialidades medicas (especificar)
topic Materias::Investigación::32 Ciencias médicas::3299 otras especialidades medicas (especificar)
description The study of mitochondria during the last years has revealed that this organelle plays an important role in the development and onset of neurodegenerative disorders such as Parkinson’s disease. The main hallmarks found in post‐mortem studies remark the importance of brain free radicals levels, the alteration in brain metabolic parameters and the presence of xenobiotics like metals for the neurodegenerative processes. Also, any energetic deficit related with the metabolic impairment due to an exposition to toxics or an increase in oxidative stress might be a favorable condition for the onset of Parkinson’s disease. Within this framework, and in order to gain insight in the aetiology of Parkinson’s disease, this Thesis was developed as a bioenergetics study focused to oxidative stress, Parkinson’s disease, and aluminium.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-09-03
2014
2014-09-03
dc.type.none.fl_str_mv doctoral thesis
http://purl.org/coar/resource_type/c_db06
dc.type.openaire.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv http://hdl.handle.net/10347/11435
url http://hdl.handle.net/10347/11435
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.gl
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.gl
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
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