Dictionary-based Protoacoustic Dose Map Imaging for Proton Range Verification

Proton radiotherapy has the potential to provide state-of-the-art dose conformality in the tumor area, reducing possible adverse effects on surrounding organs at risk. However, uncertainties in the exact location of the proton Bragg peak inside the patient prevent this technique from achieving full...

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Detalles Bibliográficos
Autores: Freijo Escudero, Clara, López Herraiz, Joaquín, Sánchez Parcerisa, Daniel, Udías Moinelo, José Manuel
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/7696
Acceso en línea:https://hdl.handle.net/20.500.14352/7696
Access Level:acceso abierto
Palabra clave:Protoacoustics
Thermoacoustics
Ultrasounds
Proton therapy
Proton range verification
Física (Física)
Oncología
22 Física
3201.01 Oncología
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oai_identifier_str oai:docta.ucm.es:20.500.14352/7696
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spelling Dictionary-based Protoacoustic Dose Map Imaging for Proton Range VerificationFreijo Escudero, ClaraLópez Herraiz, JoaquínSánchez Parcerisa, DanielUdías Moinelo, José ManuelProtoacousticsThermoacousticsUltrasoundsProton therapyProton range verificationFísica (Física)Oncología22 Física3201.01 OncologíaProton radiotherapy has the potential to provide state-of-the-art dose conformality in the tumor area, reducing possible adverse effects on surrounding organs at risk. However, uncertainties in the exact location of the proton Bragg peak inside the patient prevent this technique from achieving full clinical potential. In this context, in vivo verification of the range of protons in patients is key to reduce uncertainty margins. Protoacoustic range verification employs acoustic pressure waves generated by protons due to the radio-induced thermoacoustic effect to reconstruct the dose deposited in a patient during proton therapy. In this paper, we propose to use the a priori knowledge of the shape of the proton dose distribution to create a dictionary with the expected ultrasonic signals at predetermined detector locations. Using this dictionary, the reconstruction of deposited dose is performed by matching pre-calculated dictionary acoustic signals with data acquired online during treatment. The dictionary method was evaluated on a single-field proton plan for a prostate cancer patient. Dose calculation was performed with the open-source treatment planning system matRad, while acoustic wave propagation was carried out with k-Wave. We studied the ability of the proposed dictionary method to detect range variations caused by anatomical changes in tissue density, and alterations of lateral and longitudinal beam position. Our results show that the dictionary-based protoacoustic method was able to identify the changes in range originated by all the alterations introduced, with an average accuracy of 1.4 mm. This procedure could be used for in vivo verification, comparing the measured signals with the precalculated dictionary.ElsevierUniversidad Complutense de Madrid20212021-01-1320212021-01-13journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/7696reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución-NoComercial-SinDerivadas 3.0 Españahttps://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/76962026-06-02T12:44:21Z
dc.title.none.fl_str_mv Dictionary-based Protoacoustic Dose Map Imaging for Proton Range Verification
title Dictionary-based Protoacoustic Dose Map Imaging for Proton Range Verification
spellingShingle Dictionary-based Protoacoustic Dose Map Imaging for Proton Range Verification
Freijo Escudero, Clara
Protoacoustics
Thermoacoustics
Ultrasounds
Proton therapy
Proton range verification
Física (Física)
Oncología
22 Física
3201.01 Oncología
title_short Dictionary-based Protoacoustic Dose Map Imaging for Proton Range Verification
title_full Dictionary-based Protoacoustic Dose Map Imaging for Proton Range Verification
title_fullStr Dictionary-based Protoacoustic Dose Map Imaging for Proton Range Verification
title_full_unstemmed Dictionary-based Protoacoustic Dose Map Imaging for Proton Range Verification
title_sort Dictionary-based Protoacoustic Dose Map Imaging for Proton Range Verification
dc.creator.none.fl_str_mv Freijo Escudero, Clara
López Herraiz, Joaquín
Sánchez Parcerisa, Daniel
Udías Moinelo, José Manuel
author Freijo Escudero, Clara
author_facet Freijo Escudero, Clara
López Herraiz, Joaquín
Sánchez Parcerisa, Daniel
Udías Moinelo, José Manuel
author_role author
author2 López Herraiz, Joaquín
Sánchez Parcerisa, Daniel
Udías Moinelo, José Manuel
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv Protoacoustics
Thermoacoustics
Ultrasounds
Proton therapy
Proton range verification
Física (Física)
Oncología
22 Física
3201.01 Oncología
topic Protoacoustics
Thermoacoustics
Ultrasounds
Proton therapy
Proton range verification
Física (Física)
Oncología
22 Física
3201.01 Oncología
description Proton radiotherapy has the potential to provide state-of-the-art dose conformality in the tumor area, reducing possible adverse effects on surrounding organs at risk. However, uncertainties in the exact location of the proton Bragg peak inside the patient prevent this technique from achieving full clinical potential. In this context, in vivo verification of the range of protons in patients is key to reduce uncertainty margins. Protoacoustic range verification employs acoustic pressure waves generated by protons due to the radio-induced thermoacoustic effect to reconstruct the dose deposited in a patient during proton therapy. In this paper, we propose to use the a priori knowledge of the shape of the proton dose distribution to create a dictionary with the expected ultrasonic signals at predetermined detector locations. Using this dictionary, the reconstruction of deposited dose is performed by matching pre-calculated dictionary acoustic signals with data acquired online during treatment. The dictionary method was evaluated on a single-field proton plan for a prostate cancer patient. Dose calculation was performed with the open-source treatment planning system matRad, while acoustic wave propagation was carried out with k-Wave. We studied the ability of the proposed dictionary method to detect range variations caused by anatomical changes in tissue density, and alterations of lateral and longitudinal beam position. Our results show that the dictionary-based protoacoustic method was able to identify the changes in range originated by all the alterations introduced, with an average accuracy of 1.4 mm. This procedure could be used for in vivo verification, comparing the measured signals with the precalculated dictionary.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-13
2021
2021-01-13
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/7696
url https://hdl.handle.net/20.500.14352/7696
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial-SinDerivadas 3.0 España
https://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial-SinDerivadas 3.0 España
https://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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