Ex Vivo Permeation of Carprofen Vehiculated by PLGA Nanoparticles through Porcine Mucous Membranes and Ophthalmic Tissues

(1) Background: Carprofen (CP), 2-(6-chlorocarbazole) propionic acid, is used as an anti-inflammatory, analgesic and anti-pyretic agent and it belongs to the family of non-steroidal anti-inflammatory drugs (NSAIDs). CP has some adverse reactions in systemic administration; for this reason, topical a...

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Autores: Gómez, Lidia, Parra Coca, Alexander, Calpena Campmany, Ana Cristina, Gimeno Sandig, Álvaro, Gómez de Aranda Pulgarín, Inmaculada, Boix Montañés, Antonio de Pádua
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/161798
Acceso en línea:https://hdl.handle.net/2445/161798
Access Level:acceso abierto
Palabra clave:Nanopartícules
Solucions (Farmàcia)
Sistemes d'alliberament de medicaments
Agents antiinflamatoris
Malalties dels animals
Porc
Assaigs clínics
Nanoparticles
Solutions (Pharmacy)
Drug delivery systems
Antiinflammatory agents
Animal diseases
Swine
Clinical trials
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spelling Ex Vivo Permeation of Carprofen Vehiculated by PLGA Nanoparticles through Porcine Mucous Membranes and Ophthalmic TissuesGómez, LidiaParra Coca, AlexanderCalpena Campmany, Ana CristinaGimeno Sandig, ÁlvaroGómez de Aranda Pulgarín, InmaculadaBoix Montañés, Antonio de PáduaNanopartículesSolucions (Farmàcia)Sistemes d'alliberament de medicamentsAgents antiinflamatorisMalalties dels animalsPorcAssaigs clínicsNanoparticlesSolutions (Pharmacy)Drug delivery systemsAntiinflammatory agentsAnimal diseasesSwineClinical trials(1) Background: Carprofen (CP), 2-(6-chlorocarbazole) propionic acid, is used as an anti-inflammatory, analgesic and anti-pyretic agent and it belongs to the family of non-steroidal anti-inflammatory drugs (NSAIDs). CP has some adverse reactions in systemic administration; for this reason, topical administration with CP nanoparticles (CP-NPs) can be an optimal alternative. The main objective of this work is the investigation of ex vivo permeation of CP through different types of porcine mucous membranes (buccal, sublingual and vaginal) and ophthalmic tissues (cornea, sclera and conjunctiva) to compare the influence of CP-NPs formulation over a CP solution (CP-Solution). (2) Methods: The ex vivo permeation profiles were evaluated using Franz diffusion cells. Furthermore, in vivo studies were performed to verify that the formulations did not affect the cell structure and to establish the amount retained (Qr) in the tissues. (3) Results: Permeation of CP-NPs is more effective in terms of drug retention in almost all tissues (with the exception of sclera and sublingual). In vivo studies show that neither of the two formulations affects tissue structure, so both formulations are safe. (4) Conclusions: It was concluded that CP-NPs may be a useful tool for the topical treatment of local inflammation in veterinary and human medicine.MDPI2020202020202020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/161798Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/nano10020355Nanomaterials, 2020, vol. 10, num. 2, p. 355https://doi.org/10.3390/nano10020355cc-by (c) Gomez, Lidia et al., 2020http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1617982026-05-29T05:05:01Z
dc.title.none.fl_str_mv Ex Vivo Permeation of Carprofen Vehiculated by PLGA Nanoparticles through Porcine Mucous Membranes and Ophthalmic Tissues
title Ex Vivo Permeation of Carprofen Vehiculated by PLGA Nanoparticles through Porcine Mucous Membranes and Ophthalmic Tissues
spellingShingle Ex Vivo Permeation of Carprofen Vehiculated by PLGA Nanoparticles through Porcine Mucous Membranes and Ophthalmic Tissues
Gómez, Lidia
Nanopartícules
Solucions (Farmàcia)
Sistemes d'alliberament de medicaments
Agents antiinflamatoris
Malalties dels animals
Porc
Assaigs clínics
Nanoparticles
Solutions (Pharmacy)
Drug delivery systems
Antiinflammatory agents
Animal diseases
Swine
Clinical trials
title_short Ex Vivo Permeation of Carprofen Vehiculated by PLGA Nanoparticles through Porcine Mucous Membranes and Ophthalmic Tissues
title_full Ex Vivo Permeation of Carprofen Vehiculated by PLGA Nanoparticles through Porcine Mucous Membranes and Ophthalmic Tissues
title_fullStr Ex Vivo Permeation of Carprofen Vehiculated by PLGA Nanoparticles through Porcine Mucous Membranes and Ophthalmic Tissues
title_full_unstemmed Ex Vivo Permeation of Carprofen Vehiculated by PLGA Nanoparticles through Porcine Mucous Membranes and Ophthalmic Tissues
title_sort Ex Vivo Permeation of Carprofen Vehiculated by PLGA Nanoparticles through Porcine Mucous Membranes and Ophthalmic Tissues
dc.creator.none.fl_str_mv Gómez, Lidia
Parra Coca, Alexander
Calpena Campmany, Ana Cristina
Gimeno Sandig, Álvaro
Gómez de Aranda Pulgarín, Inmaculada
Boix Montañés, Antonio de Pádua
author Gómez, Lidia
author_facet Gómez, Lidia
Parra Coca, Alexander
Calpena Campmany, Ana Cristina
Gimeno Sandig, Álvaro
Gómez de Aranda Pulgarín, Inmaculada
Boix Montañés, Antonio de Pádua
author_role author
author2 Parra Coca, Alexander
Calpena Campmany, Ana Cristina
Gimeno Sandig, Álvaro
Gómez de Aranda Pulgarín, Inmaculada
Boix Montañés, Antonio de Pádua
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Nanopartícules
Solucions (Farmàcia)
Sistemes d'alliberament de medicaments
Agents antiinflamatoris
Malalties dels animals
Porc
Assaigs clínics
Nanoparticles
Solutions (Pharmacy)
Drug delivery systems
Antiinflammatory agents
Animal diseases
Swine
Clinical trials
topic Nanopartícules
Solucions (Farmàcia)
Sistemes d'alliberament de medicaments
Agents antiinflamatoris
Malalties dels animals
Porc
Assaigs clínics
Nanoparticles
Solutions (Pharmacy)
Drug delivery systems
Antiinflammatory agents
Animal diseases
Swine
Clinical trials
description (1) Background: Carprofen (CP), 2-(6-chlorocarbazole) propionic acid, is used as an anti-inflammatory, analgesic and anti-pyretic agent and it belongs to the family of non-steroidal anti-inflammatory drugs (NSAIDs). CP has some adverse reactions in systemic administration; for this reason, topical administration with CP nanoparticles (CP-NPs) can be an optimal alternative. The main objective of this work is the investigation of ex vivo permeation of CP through different types of porcine mucous membranes (buccal, sublingual and vaginal) and ophthalmic tissues (cornea, sclera and conjunctiva) to compare the influence of CP-NPs formulation over a CP solution (CP-Solution). (2) Methods: The ex vivo permeation profiles were evaluated using Franz diffusion cells. Furthermore, in vivo studies were performed to verify that the formulations did not affect the cell structure and to establish the amount retained (Qr) in the tissues. (3) Results: Permeation of CP-NPs is more effective in terms of drug retention in almost all tissues (with the exception of sclera and sublingual). In vivo studies show that neither of the two formulations affects tissue structure, so both formulations are safe. (4) Conclusions: It was concluded that CP-NPs may be a useful tool for the topical treatment of local inflammation in veterinary and human medicine.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/161798
url https://hdl.handle.net/2445/161798
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/nano10020355
Nanomaterials, 2020, vol. 10, num. 2, p. 355
https://doi.org/10.3390/nano10020355
dc.rights.none.fl_str_mv cc-by (c) Gomez, Lidia et al., 2020
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Gomez, Lidia et al., 2020
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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