The effects of white matter hyperintensities on MEG power spectra in population with mild cognitive impairment

Cerebrovascular disease is responsible for up to 20% of cases of dementia worldwide, but also it is a major comorbid contributor to the progression of other neurodegenerative diseases, like Alzheimer’s disease. White matter hyperintensities (WMH) are the most prevalent imaging marker in cerebrovascu...

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Autores: Torres Simón, Lucía, Cuesta Prieto, Pablo, del Cerro León, Alberto, Chino, Brenda, Orozco, Lucia H., Marsh, Elisabeth B., Gil Gregorio, Pedro, Maestu Unturbe, Fernando
Formato: artículo
Fecha de publicación:2023
País:España
Recursos:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/100909
Acesso em linha:https://hdl.handle.net/20.500.14352/100909
Access Level:acceso abierto
Palavra-chave:612.8
Cerebrovascular disease (CVD)
small vessel cerebral disease
white matter hyperintensites
mild cognitive impairment
magnetoencephalography (MEG)
power spectra analysis
Neurociencias (Medicina)
2490 Neurociencias
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oai_identifier_str oai:docta.ucm.es:20.500.14352/100909
network_acronym_str ES
network_name_str España
repository_id_str
spelling The effects of white matter hyperintensities on MEG power spectra in population with mild cognitive impairmentTorres Simón, LucíaCuesta Prieto, Pablodel Cerro León, AlbertoChino, BrendaOrozco, Lucia H.Marsh, Elisabeth B.Gil Gregorio, PedroMaestu Unturbe, Fernando612.8Cerebrovascular disease (CVD)small vessel cerebral diseasewhite matter hyperintensitesmild cognitive impairmentmagnetoencephalography (MEG)power spectra analysisNeurociencias (Medicina)2490 NeurocienciasCerebrovascular disease is responsible for up to 20% of cases of dementia worldwide, but also it is a major comorbid contributor to the progression of other neurodegenerative diseases, like Alzheimer’s disease. White matter hyperintensities (WMH) are the most prevalent imaging marker in cerebrovascular disease. The presence and progression of WMH in the brain have been associated with general cognitive impairment and the risk to develop all types of dementia. The aim of this piece of work is the assessment of brain functional differences in an MCI population based on the WMH volume. One-hundred and twenty-nine individuals with mild cognitive impairment (MCI) underwent a neuropsychological evaluation, MRI assessment (T1 and Flair), and MEG recordings (5 min of eyes closed resting state). Those participants were further classified into vascular MCI (vMCI; n = 61, mean age 75 ± 4 years, 35 females) or non-vascular MCI (nvMCI; n = 56, mean age 72 ± 5 years, 36 females) according to their WMH total volume, assessed with an automatic detection toolbox, LST (SPM12). We used a completely data-driven approach to evaluate the differences in the power spectra between the groups. Interestingly, three clusters emerged: One cluster with widespread larger theta power and two clusters located in both temporal regions with smaller beta power for vMCI compared to nvMCI. Those power signatures were also associated with cognitive performance and hippocampal volume. Early identification and classification of dementia pathogenesis is a crucially important goal for the search for more effective management approaches. These findings could help to understand and try to palliate the contribution of WMH to particular symptoms in mixed dementia progress.FrontiersUniversidad Complutense de Madrid20232023-02-1520232023-02-15journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/100909reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1009092026-06-02T12:44:21Z
dc.title.none.fl_str_mv The effects of white matter hyperintensities on MEG power spectra in population with mild cognitive impairment
title The effects of white matter hyperintensities on MEG power spectra in population with mild cognitive impairment
spellingShingle The effects of white matter hyperintensities on MEG power spectra in population with mild cognitive impairment
Torres Simón, Lucía
612.8
Cerebrovascular disease (CVD)
small vessel cerebral disease
white matter hyperintensites
mild cognitive impairment
magnetoencephalography (MEG)
power spectra analysis
Neurociencias (Medicina)
2490 Neurociencias
title_short The effects of white matter hyperintensities on MEG power spectra in population with mild cognitive impairment
title_full The effects of white matter hyperintensities on MEG power spectra in population with mild cognitive impairment
title_fullStr The effects of white matter hyperintensities on MEG power spectra in population with mild cognitive impairment
title_full_unstemmed The effects of white matter hyperintensities on MEG power spectra in population with mild cognitive impairment
title_sort The effects of white matter hyperintensities on MEG power spectra in population with mild cognitive impairment
dc.creator.none.fl_str_mv Torres Simón, Lucía
Cuesta Prieto, Pablo
del Cerro León, Alberto
Chino, Brenda
Orozco, Lucia H.
Marsh, Elisabeth B.
Gil Gregorio, Pedro
Maestu Unturbe, Fernando
author Torres Simón, Lucía
author_facet Torres Simón, Lucía
Cuesta Prieto, Pablo
del Cerro León, Alberto
Chino, Brenda
Orozco, Lucia H.
Marsh, Elisabeth B.
Gil Gregorio, Pedro
Maestu Unturbe, Fernando
author_role author
author2 Cuesta Prieto, Pablo
del Cerro León, Alberto
Chino, Brenda
Orozco, Lucia H.
Marsh, Elisabeth B.
Gil Gregorio, Pedro
Maestu Unturbe, Fernando
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 612.8
Cerebrovascular disease (CVD)
small vessel cerebral disease
white matter hyperintensites
mild cognitive impairment
magnetoencephalography (MEG)
power spectra analysis
Neurociencias (Medicina)
2490 Neurociencias
topic 612.8
Cerebrovascular disease (CVD)
small vessel cerebral disease
white matter hyperintensites
mild cognitive impairment
magnetoencephalography (MEG)
power spectra analysis
Neurociencias (Medicina)
2490 Neurociencias
description Cerebrovascular disease is responsible for up to 20% of cases of dementia worldwide, but also it is a major comorbid contributor to the progression of other neurodegenerative diseases, like Alzheimer’s disease. White matter hyperintensities (WMH) are the most prevalent imaging marker in cerebrovascular disease. The presence and progression of WMH in the brain have been associated with general cognitive impairment and the risk to develop all types of dementia. The aim of this piece of work is the assessment of brain functional differences in an MCI population based on the WMH volume. One-hundred and twenty-nine individuals with mild cognitive impairment (MCI) underwent a neuropsychological evaluation, MRI assessment (T1 and Flair), and MEG recordings (5 min of eyes closed resting state). Those participants were further classified into vascular MCI (vMCI; n = 61, mean age 75 ± 4 years, 35 females) or non-vascular MCI (nvMCI; n = 56, mean age 72 ± 5 years, 36 females) according to their WMH total volume, assessed with an automatic detection toolbox, LST (SPM12). We used a completely data-driven approach to evaluate the differences in the power spectra between the groups. Interestingly, three clusters emerged: One cluster with widespread larger theta power and two clusters located in both temporal regions with smaller beta power for vMCI compared to nvMCI. Those power signatures were also associated with cognitive performance and hippocampal volume. Early identification and classification of dementia pathogenesis is a crucially important goal for the search for more effective management approaches. These findings could help to understand and try to palliate the contribution of WMH to particular symptoms in mixed dementia progress.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-02-15
2023
2023-02-15
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/100909
url https://hdl.handle.net/20.500.14352/100909
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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