Long Non-Coding RNAs As Potential Novel Prognostic Biomarkers in Colorectal Cancer
Colorectal cancer (CRC) is the fourth most common cause of death worldwide. Surgery is usually the first line of treatment for patients with CRC but many tumors with similar histopathological features show significantly different clinical outcomes. The discovery of robust prognostic biomarkers in pa...
| Autores: | , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2016 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:185874 |
| Acceso en línea: | https://ddd.uab.cat/record/185874 https://dx.doi.org/urn:doi:10.3389/fgene.2016.00054 |
| Access Level: | acceso abierto |
| Palabra clave: | Ñong non-coding RNA NcRNA Prognostic marker Colorectal cancer Biomarker |
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Long Non-Coding RNAs As Potential Novel Prognostic Biomarkers in Colorectal CancerSaus, Ester|||0000-0002-2519-111XBrunet Vega, Anna|||0000-0002-2723-0469Iraola-Guzmán, Susana|||0000-0003-3359-1241Pegueroles Queralt, Maria Cinta|||0000-0003-0701-9866Gabaldón, Toni|||0000-0003-0019-1735Pericay, Carles|||0000-0002-4975-7851Ñong non-coding RNANcRNAPrognostic markerColorectal cancerBiomarkerColorectal cancer (CRC) is the fourth most common cause of death worldwide. Surgery is usually the first line of treatment for patients with CRC but many tumors with similar histopathological features show significantly different clinical outcomes. The discovery of robust prognostic biomarkers in patients with CRC is imperative to achieve more effective treatment strategies and improve patient's care. Recent progress in next generation sequencing methods and transcriptome analysis has revealed that a much larger part of the genome is transcribed into RNA than previously assumed. Collectively referred to as non-coding RNAs (ncRNAs), some of these RNA molecules such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) have been shown to be altered and to play critical roles in tumor biology. This discovery leads to exciting possibilities for personalized cancer diagnosis, and therapy. Many lncRNAs are tissue and cancer-type specific and have already revealed to be useful as prognostic markers. In this review, we focus on recent findings concerning aberrant expression of lncRNAs in CRC tumors and emphasize their prognostic potential in CRC. Further studies focused on the mechanisms of action of lncRNAs will contribute to the development of novel biomarkers for diagnosis and disease progression.Universitat Autònoma de Barcelona 22016-01-0120162016-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/185874https://dx.doi.org/urn:doi:10.3389/fgene.2016.00054reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 SEV-2012-0208Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 BIO2012-37161European Commission https://doi.org/10.13039/501100000780 642095open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:1858742026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Long Non-Coding RNAs As Potential Novel Prognostic Biomarkers in Colorectal Cancer |
| title |
Long Non-Coding RNAs As Potential Novel Prognostic Biomarkers in Colorectal Cancer |
| spellingShingle |
Long Non-Coding RNAs As Potential Novel Prognostic Biomarkers in Colorectal Cancer Saus, Ester|||0000-0002-2519-111X Ñong non-coding RNA NcRNA Prognostic marker Colorectal cancer Biomarker |
| title_short |
Long Non-Coding RNAs As Potential Novel Prognostic Biomarkers in Colorectal Cancer |
| title_full |
Long Non-Coding RNAs As Potential Novel Prognostic Biomarkers in Colorectal Cancer |
| title_fullStr |
Long Non-Coding RNAs As Potential Novel Prognostic Biomarkers in Colorectal Cancer |
| title_full_unstemmed |
Long Non-Coding RNAs As Potential Novel Prognostic Biomarkers in Colorectal Cancer |
| title_sort |
Long Non-Coding RNAs As Potential Novel Prognostic Biomarkers in Colorectal Cancer |
| dc.creator.none.fl_str_mv |
Saus, Ester|||0000-0002-2519-111X Brunet Vega, Anna|||0000-0002-2723-0469 Iraola-Guzmán, Susana|||0000-0003-3359-1241 Pegueroles Queralt, Maria Cinta|||0000-0003-0701-9866 Gabaldón, Toni|||0000-0003-0019-1735 Pericay, Carles|||0000-0002-4975-7851 |
| author |
Saus, Ester|||0000-0002-2519-111X |
| author_facet |
Saus, Ester|||0000-0002-2519-111X Brunet Vega, Anna|||0000-0002-2723-0469 Iraola-Guzmán, Susana|||0000-0003-3359-1241 Pegueroles Queralt, Maria Cinta|||0000-0003-0701-9866 Gabaldón, Toni|||0000-0003-0019-1735 Pericay, Carles|||0000-0002-4975-7851 |
| author_role |
author |
| author2 |
Brunet Vega, Anna|||0000-0002-2723-0469 Iraola-Guzmán, Susana|||0000-0003-3359-1241 Pegueroles Queralt, Maria Cinta|||0000-0003-0701-9866 Gabaldón, Toni|||0000-0003-0019-1735 Pericay, Carles|||0000-0002-4975-7851 |
| author2_role |
author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona |
| dc.subject.none.fl_str_mv |
Ñong non-coding RNA NcRNA Prognostic marker Colorectal cancer Biomarker |
| topic |
Ñong non-coding RNA NcRNA Prognostic marker Colorectal cancer Biomarker |
| description |
Colorectal cancer (CRC) is the fourth most common cause of death worldwide. Surgery is usually the first line of treatment for patients with CRC but many tumors with similar histopathological features show significantly different clinical outcomes. The discovery of robust prognostic biomarkers in patients with CRC is imperative to achieve more effective treatment strategies and improve patient's care. Recent progress in next generation sequencing methods and transcriptome analysis has revealed that a much larger part of the genome is transcribed into RNA than previously assumed. Collectively referred to as non-coding RNAs (ncRNAs), some of these RNA molecules such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) have been shown to be altered and to play critical roles in tumor biology. This discovery leads to exciting possibilities for personalized cancer diagnosis, and therapy. Many lncRNAs are tissue and cancer-type specific and have already revealed to be useful as prognostic markers. In this review, we focus on recent findings concerning aberrant expression of lncRNAs in CRC tumors and emphasize their prognostic potential in CRC. Further studies focused on the mechanisms of action of lncRNAs will contribute to the development of novel biomarkers for diagnosis and disease progression. |
| publishDate |
2016 |
| dc.date.none.fl_str_mv |
2 2016-01-01 2016 2016-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/185874 https://dx.doi.org/urn:doi:10.3389/fgene.2016.00054 |
| url |
https://ddd.uab.cat/record/185874 https://dx.doi.org/urn:doi:10.3389/fgene.2016.00054 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
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eng |
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Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 SEV-2012-0208 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 BIO2012-37161 European Commission https://doi.org/10.13039/501100000780 642095 |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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