Interleukin-6 myokine signaling in skeletal muscle: a double-edged sword?

Interleukin (IL)-6 is a cytokine with pleiotropic functions in different tissues and organs. Skeletal muscle produces and releases significant levels of IL-6 after prolonged exercise and is therefore considered as a myokine. Muscle is also an important target of the cytokine. IL-6 signaling has been...

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Detalhes bibliográficos
Autores: Muñoz Cánoves, Pura, 1962-, Scheele, Camilla, Pedersen, Bente K., Serrano, Antonio L.
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:España
Recursos:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/25260
Acesso em linha:http://hdl.handle.net/10230/25260
http://dx.doi.org/10.1111/febs.12338
Access Level:acceso abierto
Palavra-chave:Músculs -- Creixement
Growth/atrophy
IL-6
Inflammation
Metabolism
Myogenesis
Myokine
Regeneration
Satellite cell
Signaling
Pathway
Skeletal muscle
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spelling Interleukin-6 myokine signaling in skeletal muscle: a double-edged sword?Muñoz Cánoves, Pura, 1962-Scheele, CamillaPedersen, Bente K.Serrano, Antonio L.Músculs -- CreixementGrowth/atrophyIL-6InflammationMetabolismMyogenesisMyokineRegenerationSatellite cellSignalingPathwaySkeletal muscleInterleukin (IL)-6 is a cytokine with pleiotropic functions in different tissues and organs. Skeletal muscle produces and releases significant levels of IL-6 after prolonged exercise and is therefore considered as a myokine. Muscle is also an important target of the cytokine. IL-6 signaling has been associated with stimulation of hypertrophic muscle growth and myogenesis through regulation of the proliferative capacity of muscle stem cells. Additional beneficial effects of IL-6 include regulation of energy metabolism, which is related to the capacity of actively contracting muscle to synthesize and release IL-6. Paradoxically, deleterious actions for IL-6 have also been proposed, such as promotion of atrophy and muscle wasting. We review the current evidence for these apparently contradictory effects, the mechanisms involved and discuss their possible biological implicationsThe authors acknowledge funding from EU-FP7 (Myoage) and MICINN (SAF2009-09782, FIS-PS09/01267, SAF2012-38547, PLE2009-0124, CIBERNED), AFM, Fundación Marató-TV3, MDA, EU-FP7 (Optistem and Endostem). The Centre of Inflammation and Metabolism (CIM) is supported by a grant from the Danish National Research Foundation (DNRF55).Wiley201520152013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/25260http://dx.doi.org/10.1111/febs.12338reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésFEBS journal. 2013;280(17):4131-48info:eu-repo/grantAgreement/ES/3PN/SAF2012-38547info:eu-repo/grantAgreement/ES/3PN/SAF2009-09782info:eu-repo/grantAgreement/ES/3PN/PLE2009-0124© The Authors. FEBS Journal published by John Wiley & Sons Ltd on behalf of FEBS. This is an open access article under the terms of the Creative Commons Attribution-Non Commercial-NoDerivs Licence, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/252602026-06-12T07:21:37Z
dc.title.none.fl_str_mv Interleukin-6 myokine signaling in skeletal muscle: a double-edged sword?
title Interleukin-6 myokine signaling in skeletal muscle: a double-edged sword?
spellingShingle Interleukin-6 myokine signaling in skeletal muscle: a double-edged sword?
Muñoz Cánoves, Pura, 1962-
Músculs -- Creixement
Growth/atrophy
IL-6
Inflammation
Metabolism
Myogenesis
Myokine
Regeneration
Satellite cell
Signaling
Pathway
Skeletal muscle
title_short Interleukin-6 myokine signaling in skeletal muscle: a double-edged sword?
title_full Interleukin-6 myokine signaling in skeletal muscle: a double-edged sword?
title_fullStr Interleukin-6 myokine signaling in skeletal muscle: a double-edged sword?
title_full_unstemmed Interleukin-6 myokine signaling in skeletal muscle: a double-edged sword?
title_sort Interleukin-6 myokine signaling in skeletal muscle: a double-edged sword?
dc.creator.none.fl_str_mv Muñoz Cánoves, Pura, 1962-
Scheele, Camilla
Pedersen, Bente K.
Serrano, Antonio L.
author Muñoz Cánoves, Pura, 1962-
author_facet Muñoz Cánoves, Pura, 1962-
Scheele, Camilla
Pedersen, Bente K.
Serrano, Antonio L.
author_role author
author2 Scheele, Camilla
Pedersen, Bente K.
Serrano, Antonio L.
author2_role author
author
author
dc.subject.none.fl_str_mv Músculs -- Creixement
Growth/atrophy
IL-6
Inflammation
Metabolism
Myogenesis
Myokine
Regeneration
Satellite cell
Signaling
Pathway
Skeletal muscle
topic Músculs -- Creixement
Growth/atrophy
IL-6
Inflammation
Metabolism
Myogenesis
Myokine
Regeneration
Satellite cell
Signaling
Pathway
Skeletal muscle
description Interleukin (IL)-6 is a cytokine with pleiotropic functions in different tissues and organs. Skeletal muscle produces and releases significant levels of IL-6 after prolonged exercise and is therefore considered as a myokine. Muscle is also an important target of the cytokine. IL-6 signaling has been associated with stimulation of hypertrophic muscle growth and myogenesis through regulation of the proliferative capacity of muscle stem cells. Additional beneficial effects of IL-6 include regulation of energy metabolism, which is related to the capacity of actively contracting muscle to synthesize and release IL-6. Paradoxically, deleterious actions for IL-6 have also been proposed, such as promotion of atrophy and muscle wasting. We review the current evidence for these apparently contradictory effects, the mechanisms involved and discuss their possible biological implications
publishDate 2013
dc.date.none.fl_str_mv 2013
2015
2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/25260
http://dx.doi.org/10.1111/febs.12338
url http://hdl.handle.net/10230/25260
http://dx.doi.org/10.1111/febs.12338
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv FEBS journal. 2013;280(17):4131-48
info:eu-repo/grantAgreement/ES/3PN/SAF2012-38547
info:eu-repo/grantAgreement/ES/3PN/SAF2009-09782
info:eu-repo/grantAgreement/ES/3PN/PLE2009-0124
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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