Adolescent alcohol consumption predicted by differences in electrophysiological functional connectivity and neuroanatomy
Alcohol consumption during adolescence has been associated with neuroanatomical abnormalities and the appearance of future disorders. However, the latest advances in this field point to the existence of risk profiles which may lead to some individuals into an early consumption. To date, some studies...
| Authors: | , , , , , , , , |
|---|---|
| Format: | article |
| Publication Date: | 2024 |
| Country: | España |
| Institution: | Universidad Complutense de Madrid (UCM) |
| Repository: | Docta Complutense |
| Language: | English |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/110375 |
| Online Access: | https://hdl.handle.net/20.500.14352/110375 |
| Access Level: | Open access |
| Keyword: | 612.8 159.9 Neurociencias (Medicina) 61 Psicología |
| id |
ES_ebb30ffdf71616ca54cf59d1f6ede83d |
|---|---|
| oai_identifier_str |
oai:docta.ucm.es:20.500.14352/110375 |
| network_acronym_str |
ES |
| network_name_str |
España |
| repository_id_str |
|
| spelling |
Adolescent alcohol consumption predicted by differences in electrophysiological functional connectivity and neuroanatomydel Cerro-León, AlbertoAntón Toro, Luis FernandoShpakivska- Bilan, DanylynaUceta, MarcosSantos Mayo, AlejandroCuesta Prieto, PabloBruña Fernández, RicardoGarcía Moreno, Luis MiguelMaestu Unturbe, Fernando612.8159.9Neurociencias (Medicina)61 PsicologíaAlcohol consumption during adolescence has been associated with neuroanatomical abnormalities and the appearance of future disorders. However, the latest advances in this field point to the existence of risk profiles which may lead to some individuals into an early consumption. To date, some studies have established predictive models of consumption based on sociodemographic, behavioral, and anatomical–functional variables using MRI. However, the neuroimaging variables employed are usually restricted to local and hemodynamic phenomena. Given the potential of connectome approaches, and the high temporal dynamics of electrophysiology, we decided to explore the relationship between future alcohol consumption and electrophysiological connectivity measured by MEG in a cohort of 83 individuals aged 14 to 16. As a result, we found a positive correlation between alcohol consumption and the functional connectivity in frontal, parietal, and frontoparietal connections. Once this relationship was described, multivariate linear regression analyses were used to evaluate the predictive capacity of functional connectivity in conjunction with other neuroanatomical and behavioral variables described in the literature. Finally, the multivariate linear regression analysis determined the importance of anatomical and functional variables in the prediction of alcohol consumption but failed to find associations with impulsivity, sensation seeking, and executive function scales. In conclusion, the predictive traits obtained in these models were closely associated with changes occurring during adolescence, suggesting the existence of different paths in neurodevelopment that have the potential to influence adolescents’ relationship with alcohol consumption.Washington, D.C. National Academy of SciencesUniversidad Complutense de Madrid20242024-10-0820242024-10-08journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/110375reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1103752026-06-02T12:44:21Z |
| dc.title.none.fl_str_mv |
Adolescent alcohol consumption predicted by differences in electrophysiological functional connectivity and neuroanatomy |
| title |
Adolescent alcohol consumption predicted by differences in electrophysiological functional connectivity and neuroanatomy |
| spellingShingle |
Adolescent alcohol consumption predicted by differences in electrophysiological functional connectivity and neuroanatomy del Cerro-León, Alberto 612.8 159.9 Neurociencias (Medicina) 61 Psicología |
| title_short |
Adolescent alcohol consumption predicted by differences in electrophysiological functional connectivity and neuroanatomy |
| title_full |
Adolescent alcohol consumption predicted by differences in electrophysiological functional connectivity and neuroanatomy |
| title_fullStr |
Adolescent alcohol consumption predicted by differences in electrophysiological functional connectivity and neuroanatomy |
| title_full_unstemmed |
Adolescent alcohol consumption predicted by differences in electrophysiological functional connectivity and neuroanatomy |
| title_sort |
Adolescent alcohol consumption predicted by differences in electrophysiological functional connectivity and neuroanatomy |
| dc.creator.none.fl_str_mv |
del Cerro-León, Alberto Antón Toro, Luis Fernando Shpakivska- Bilan, Danylyna Uceta, Marcos Santos Mayo, Alejandro Cuesta Prieto, Pablo Bruña Fernández, Ricardo García Moreno, Luis Miguel Maestu Unturbe, Fernando |
| author |
del Cerro-León, Alberto |
| author_facet |
del Cerro-León, Alberto Antón Toro, Luis Fernando Shpakivska- Bilan, Danylyna Uceta, Marcos Santos Mayo, Alejandro Cuesta Prieto, Pablo Bruña Fernández, Ricardo García Moreno, Luis Miguel Maestu Unturbe, Fernando |
| author_role |
author |
| author2 |
Antón Toro, Luis Fernando Shpakivska- Bilan, Danylyna Uceta, Marcos Santos Mayo, Alejandro Cuesta Prieto, Pablo Bruña Fernández, Ricardo García Moreno, Luis Miguel Maestu Unturbe, Fernando |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidad Complutense de Madrid |
| dc.subject.none.fl_str_mv |
612.8 159.9 Neurociencias (Medicina) 61 Psicología |
| topic |
612.8 159.9 Neurociencias (Medicina) 61 Psicología |
| description |
Alcohol consumption during adolescence has been associated with neuroanatomical abnormalities and the appearance of future disorders. However, the latest advances in this field point to the existence of risk profiles which may lead to some individuals into an early consumption. To date, some studies have established predictive models of consumption based on sociodemographic, behavioral, and anatomical–functional variables using MRI. However, the neuroimaging variables employed are usually restricted to local and hemodynamic phenomena. Given the potential of connectome approaches, and the high temporal dynamics of electrophysiology, we decided to explore the relationship between future alcohol consumption and electrophysiological connectivity measured by MEG in a cohort of 83 individuals aged 14 to 16. As a result, we found a positive correlation between alcohol consumption and the functional connectivity in frontal, parietal, and frontoparietal connections. Once this relationship was described, multivariate linear regression analyses were used to evaluate the predictive capacity of functional connectivity in conjunction with other neuroanatomical and behavioral variables described in the literature. Finally, the multivariate linear regression analysis determined the importance of anatomical and functional variables in the prediction of alcohol consumption but failed to find associations with impulsivity, sensation seeking, and executive function scales. In conclusion, the predictive traits obtained in these models were closely associated with changes occurring during adolescence, suggesting the existence of different paths in neurodevelopment that have the potential to influence adolescents’ relationship with alcohol consumption. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024 2024-10-08 2024 2024-10-08 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/20.500.14352/110375 |
| url |
https://hdl.handle.net/20.500.14352/110375 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Washington, D.C. National Academy of Sciences |
| publisher.none.fl_str_mv |
Washington, D.C. National Academy of Sciences |
| dc.source.none.fl_str_mv |
reponame:Docta Complutense instname:Universidad Complutense de Madrid (UCM) |
| instname_str |
Universidad Complutense de Madrid (UCM) |
| reponame_str |
Docta Complutense |
| collection |
Docta Complutense |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869423250504679424 |
| score |
15,811543 |