Activity of ceftazidime-avibactam against clinical and isogenic laboratory Pseudomonas aeruginosa isolates expressing combinations of most relevant β-lactam resistance mechanisms

The activity of ceftazidime-avibactam was compared with that of ceftazidime alone and meropenem against a collection of 190 Pseudomonas aeruginosa clinical isolates recovered from a multicenter study of bloodstream infections. The addition of avibactam increased ceftazidime susceptibility in the com...

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Autores: Torrens, Gabriel, Cabot, Gabriel|||0000-0002-6452-9945, Ocampo-Sosa, Alain A.|||0000-0002-9104-3115, Conejo, M. Carmen, Zamorano, Laura, Navarro Risueño, Ferran|||0000-0002-4302-2838, Pascual Leone, Álvaro|||0000-0001-8975-0382, Martínez-Martínez, Luis, Oliver, Antonio|||0000-0001-9327-1894
Tipo de recurso: artículo
Fecha de publicación:2016
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:285169
Acceso en línea:https://ddd.uab.cat/record/285169
https://dx.doi.org/urn:doi:10.1128/AAC.01282-16
Access Level:acceso abierto
Palabra clave:SDG 3 - Good Health and Well-being
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spelling Activity of ceftazidime-avibactam against clinical and isogenic laboratory Pseudomonas aeruginosa isolates expressing combinations of most relevant β-lactam resistance mechanismsTorrens, GabrielCabot, Gabriel|||0000-0002-6452-9945Ocampo-Sosa, Alain A.|||0000-0002-9104-3115Conejo, M. CarmenZamorano, LauraNavarro Risueño, Ferran|||0000-0002-4302-2838Pascual Leone, Álvaro|||0000-0001-8975-0382Martínez-Martínez, LuisOliver, Antonio|||0000-0001-9327-1894SDG 3 - Good Health and Well-beingThe activity of ceftazidime-avibactam was compared with that of ceftazidime alone and meropenem against a collection of 190 Pseudomonas aeruginosa clinical isolates recovered from a multicenter study of bloodstream infections. The addition of avibactam increased ceftazidime susceptibility in the complete collection of strains (64.7% to 91.1%) and particularly among subsets of isolates showing AmpC hyperproduction (10.9% to 76.1%) or multidrug resistance (MDR) profiles (27% to 77.8%). The MICs of ceftazidime-avibactam, in contrast with those of ceftazidime or meropenem, remained at ≤4 μg/ml for a panel of 16 P. aeruginosa PAO1 isogenic mutants expressing multiple combinations of the most relevant β-lactam resistance mechanisms. 22016-01-0120162016-01-01Articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/285169https://dx.doi.org/urn:doi:10.1128/AAC.01282-16reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 RD12/0015Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 RD16/00016open accesshttp://purl.org/coar/access_right/c_abf2Aquest material està protegit per drets d'autor i/o drets afins. Podeu utilitzar aquest material en funció del que permet la legislació de drets d'autor i drets afins d'aplicació al vostre cas. Per a d'altres usos heu d'obtenir permís del(s) titular(s) de drets.https://rightsstatements.org/vocab/InC/1.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2851692026-06-06T12:50:31Z
dc.title.none.fl_str_mv Activity of ceftazidime-avibactam against clinical and isogenic laboratory Pseudomonas aeruginosa isolates expressing combinations of most relevant β-lactam resistance mechanisms
title Activity of ceftazidime-avibactam against clinical and isogenic laboratory Pseudomonas aeruginosa isolates expressing combinations of most relevant β-lactam resistance mechanisms
spellingShingle Activity of ceftazidime-avibactam against clinical and isogenic laboratory Pseudomonas aeruginosa isolates expressing combinations of most relevant β-lactam resistance mechanisms
Torrens, Gabriel
SDG 3 - Good Health and Well-being
title_short Activity of ceftazidime-avibactam against clinical and isogenic laboratory Pseudomonas aeruginosa isolates expressing combinations of most relevant β-lactam resistance mechanisms
title_full Activity of ceftazidime-avibactam against clinical and isogenic laboratory Pseudomonas aeruginosa isolates expressing combinations of most relevant β-lactam resistance mechanisms
title_fullStr Activity of ceftazidime-avibactam against clinical and isogenic laboratory Pseudomonas aeruginosa isolates expressing combinations of most relevant β-lactam resistance mechanisms
title_full_unstemmed Activity of ceftazidime-avibactam against clinical and isogenic laboratory Pseudomonas aeruginosa isolates expressing combinations of most relevant β-lactam resistance mechanisms
title_sort Activity of ceftazidime-avibactam against clinical and isogenic laboratory Pseudomonas aeruginosa isolates expressing combinations of most relevant β-lactam resistance mechanisms
dc.creator.none.fl_str_mv Torrens, Gabriel
Cabot, Gabriel|||0000-0002-6452-9945
Ocampo-Sosa, Alain A.|||0000-0002-9104-3115
Conejo, M. Carmen
Zamorano, Laura
Navarro Risueño, Ferran|||0000-0002-4302-2838
Pascual Leone, Álvaro|||0000-0001-8975-0382
Martínez-Martínez, Luis
Oliver, Antonio|||0000-0001-9327-1894
author Torrens, Gabriel
author_facet Torrens, Gabriel
Cabot, Gabriel|||0000-0002-6452-9945
Ocampo-Sosa, Alain A.|||0000-0002-9104-3115
Conejo, M. Carmen
Zamorano, Laura
Navarro Risueño, Ferran|||0000-0002-4302-2838
Pascual Leone, Álvaro|||0000-0001-8975-0382
Martínez-Martínez, Luis
Oliver, Antonio|||0000-0001-9327-1894
author_role author
author2 Cabot, Gabriel|||0000-0002-6452-9945
Ocampo-Sosa, Alain A.|||0000-0002-9104-3115
Conejo, M. Carmen
Zamorano, Laura
Navarro Risueño, Ferran|||0000-0002-4302-2838
Pascual Leone, Álvaro|||0000-0001-8975-0382
Martínez-Martínez, Luis
Oliver, Antonio|||0000-0001-9327-1894
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv SDG 3 - Good Health and Well-being
topic SDG 3 - Good Health and Well-being
description The activity of ceftazidime-avibactam was compared with that of ceftazidime alone and meropenem against a collection of 190 Pseudomonas aeruginosa clinical isolates recovered from a multicenter study of bloodstream infections. The addition of avibactam increased ceftazidime susceptibility in the complete collection of strains (64.7% to 91.1%) and particularly among subsets of isolates showing AmpC hyperproduction (10.9% to 76.1%) or multidrug resistance (MDR) profiles (27% to 77.8%). The MICs of ceftazidime-avibactam, in contrast with those of ceftazidime or meropenem, remained at ≤4 μg/ml for a panel of 16 P. aeruginosa PAO1 isogenic mutants expressing multiple combinations of the most relevant β-lactam resistance mechanisms.
publishDate 2016
dc.date.none.fl_str_mv 2
2016-01-01
2016
2016-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/285169
https://dx.doi.org/urn:doi:10.1128/AAC.01282-16
url https://ddd.uab.cat/record/285169
https://dx.doi.org/urn:doi:10.1128/AAC.01282-16
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 RD12/0015
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 RD16/00016
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://rightsstatements.org/vocab/InC/1.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://rightsstatements.org/vocab/InC/1.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
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