Hematotesticular barrier is altered from early stages of liver cirrhosis: Effect of insulin-like growth factor 1

et al.

Detalles Bibliográficos
Autores: Castilla-Cortázar, Inma, García-Fernández, María, Díaz-Sánchez, Matías, Castilla, Alberto, Díaz-Casares, Amelia, Varela-Nieto, Isabel, González-Barón, Salvador
Tipo de recurso: artículo
Fecha de publicación:2004
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/81120
Acceso en línea:http://hdl.handle.net/10261/81120
Access Level:acceso abierto
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spelling Hematotesticular barrier is altered from early stages of liver cirrhosis: Effect of insulin-like growth factor 1Castilla-Cortázar, InmaGarcía-Fernández, MaríaDíaz-Sánchez, MatíasCastilla, AlbertoDíaz-Casares, AmeliaVarela-Nieto, IsabelGonzález-Barón, Salvadoret al.[Aim]: The pathogenesis of hypogonadism in liver cirrhosis is not well understood. Previous results from our laboratory showed that IGF-1 deficiency might play a pathogenetic role in hypogonadism of cirrhosis. The administration of IGF-1 for a short period of time reverted the testicular atrophy associated with advanced experimental cirrhosis. The aim of this study was to establish the historical progression of the described alterations in the testes, explore testicular morphology, histopathology, cellular proliferation, integrity of testicular barrier and hypophysogonadal axis in rats with no ascitic cirrhosis. [Methods]: Male Wistar rats with histologically-proven cirrhosis induced with carbon tetrachloride (CCl4) for 11 wk, were allocated into two groups (n = 12, each) to receive recombinant IGF-1 (2 μg/100 g·d, sc) for two weeks or vehicle. Healthy rats receiving vehicle were used as control group (n = 12). [Results]: Compared to controls, rats with compensated cirrhosis showed a normal testicular size and weight and very few histopathological testicular abnormalities. However, these animals showed a significant diminution of cellular proliferation and a reduction of testicular transferrin expression. In addition, pituitary-gonadal axis was altered, with significant higher levels of FSH (P<0.001 vs controls) and increased levels of LH in untreated cirrhotic animals. Interestingly, IGF-1 treatment normalized testicular transferrin expression and cellular proliferation and reduced serum levels of LH (P = ns vs controls, and P<0.01 vs untreated cirrhotic group). [Conclusion]: The testicular barrier is altered from an early stage of cirrhosis, shown by a reduction of transferrin expression in Sertoli cells, a diminished cellular proliferation and an altered gonadal axis. The treatment with IGF-1 could be also useful in this initial stage of testicular disorder associated with compensated cirrhosis. Copyright © 2004 by The WJG Press.Peer ReviewedWJG Press2013201320042013info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/81120reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://www.wjgnet.com/1007-9327/full/v10/i17/2529.htminfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/811202026-05-22T06:33:51Z
dc.title.none.fl_str_mv Hematotesticular barrier is altered from early stages of liver cirrhosis: Effect of insulin-like growth factor 1
title Hematotesticular barrier is altered from early stages of liver cirrhosis: Effect of insulin-like growth factor 1
spellingShingle Hematotesticular barrier is altered from early stages of liver cirrhosis: Effect of insulin-like growth factor 1
Castilla-Cortázar, Inma
title_short Hematotesticular barrier is altered from early stages of liver cirrhosis: Effect of insulin-like growth factor 1
title_full Hematotesticular barrier is altered from early stages of liver cirrhosis: Effect of insulin-like growth factor 1
title_fullStr Hematotesticular barrier is altered from early stages of liver cirrhosis: Effect of insulin-like growth factor 1
title_full_unstemmed Hematotesticular barrier is altered from early stages of liver cirrhosis: Effect of insulin-like growth factor 1
title_sort Hematotesticular barrier is altered from early stages of liver cirrhosis: Effect of insulin-like growth factor 1
dc.creator.none.fl_str_mv Castilla-Cortázar, Inma
García-Fernández, María
Díaz-Sánchez, Matías
Castilla, Alberto
Díaz-Casares, Amelia
Varela-Nieto, Isabel
González-Barón, Salvador
author Castilla-Cortázar, Inma
author_facet Castilla-Cortázar, Inma
García-Fernández, María
Díaz-Sánchez, Matías
Castilla, Alberto
Díaz-Casares, Amelia
Varela-Nieto, Isabel
González-Barón, Salvador
author_role author
author2 García-Fernández, María
Díaz-Sánchez, Matías
Castilla, Alberto
Díaz-Casares, Amelia
Varela-Nieto, Isabel
González-Barón, Salvador
author2_role author
author
author
author
author
author
description et al.
publishDate 2004
dc.date.none.fl_str_mv 2004
2013
2013
2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/81120
url http://hdl.handle.net/10261/81120
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://www.wjgnet.com/1007-9327/full/v10/i17/2529.htm
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv WJG Press
publisher.none.fl_str_mv WJG Press
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812455

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