Hydrogen sulphide-triggered theranostic prodrugs based on the dynamic chemistry of tetrazines

Dynamic nucleophilic aromatic substitution of tetrazines (SNTz) has been employed to build theranostic prodrugs that are activated by hydrogen sulfide. H2S is typically found in high concentrations in some kinds of cancer cells and it is able to trigger the disassembly of tetrazine prodrugs. In such...

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Autores: Perretti, Marcelle D., Pérez-Pérez, Yaiza, Soler-Carracedo, Kevin, Martín-Encinas, Endika, Alonso, Concepción, Scoccia, Jimena, Carrillo Fumero, Romen
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/302973
Acceso en línea:http://hdl.handle.net/10261/302973
Access Level:acceso abierto
Palabra clave:Hydrogen sulphide
triggered theranostic
dynamic chemistry of tetrazines
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spelling Hydrogen sulphide-triggered theranostic prodrugs based on the dynamic chemistry of tetrazinesPerretti, Marcelle D.Pérez-Pérez, YaizaSoler-Carracedo, KevinMartín-Encinas, EndikaAlonso, ConcepciónScoccia, JimenaCarrillo Fumero, RomenHydrogen sulphidetriggered theranosticdynamic chemistry of tetrazinesDynamic nucleophilic aromatic substitution of tetrazines (SNTz) has been employed to build theranostic prodrugs that are activated by hydrogen sulfide. H2S is typically found in high concentrations in some kinds of cancer cells and it is able to trigger the disassembly of tetrazine prodrugs. In such a way, a dual release of drugs and/or fluorescent compounds can be selectively triggered.This work was financially supported by Ministerio de Ciencia e Innovación (PGC2018-094503-B-C21). J.S. thanks Cabildo de Tenerife for the Agustín de Betancourt programme. M.D.P thanks the ACIISI and the European Social Fund (ESF) for a predoctoral grant.Peer reviewedRoyal Society of Chemistry (UK)Ministerio de Ciencia e Innovación (España)Cabildo de TenerifeAgencia Canaria de Investigación, Innovación y Sociedad de la InformaciónEuropean CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202320232022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/302973reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PGC2018-094503-B-C21DOI https://doi.org/10.1039/D2CC01170KSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3029732026-05-22T06:33:51Z
dc.title.none.fl_str_mv Hydrogen sulphide-triggered theranostic prodrugs based on the dynamic chemistry of tetrazines
title Hydrogen sulphide-triggered theranostic prodrugs based on the dynamic chemistry of tetrazines
spellingShingle Hydrogen sulphide-triggered theranostic prodrugs based on the dynamic chemistry of tetrazines
Perretti, Marcelle D.
Hydrogen sulphide
triggered theranostic
dynamic chemistry of tetrazines
title_short Hydrogen sulphide-triggered theranostic prodrugs based on the dynamic chemistry of tetrazines
title_full Hydrogen sulphide-triggered theranostic prodrugs based on the dynamic chemistry of tetrazines
title_fullStr Hydrogen sulphide-triggered theranostic prodrugs based on the dynamic chemistry of tetrazines
title_full_unstemmed Hydrogen sulphide-triggered theranostic prodrugs based on the dynamic chemistry of tetrazines
title_sort Hydrogen sulphide-triggered theranostic prodrugs based on the dynamic chemistry of tetrazines
dc.creator.none.fl_str_mv Perretti, Marcelle D.
Pérez-Pérez, Yaiza
Soler-Carracedo, Kevin
Martín-Encinas, Endika
Alonso, Concepción
Scoccia, Jimena
Carrillo Fumero, Romen
author Perretti, Marcelle D.
author_facet Perretti, Marcelle D.
Pérez-Pérez, Yaiza
Soler-Carracedo, Kevin
Martín-Encinas, Endika
Alonso, Concepción
Scoccia, Jimena
Carrillo Fumero, Romen
author_role author
author2 Pérez-Pérez, Yaiza
Soler-Carracedo, Kevin
Martín-Encinas, Endika
Alonso, Concepción
Scoccia, Jimena
Carrillo Fumero, Romen
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (España)
Cabildo de Tenerife
Agencia Canaria de Investigación, Innovación y Sociedad de la Información
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Hydrogen sulphide
triggered theranostic
dynamic chemistry of tetrazines
topic Hydrogen sulphide
triggered theranostic
dynamic chemistry of tetrazines
description Dynamic nucleophilic aromatic substitution of tetrazines (SNTz) has been employed to build theranostic prodrugs that are activated by hydrogen sulfide. H2S is typically found in high concentrations in some kinds of cancer cells and it is able to trigger the disassembly of tetrazine prodrugs. In such a way, a dual release of drugs and/or fluorescent compounds can be selectively triggered.
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/302973
url http://hdl.handle.net/10261/302973
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PGC2018-094503-B-C21
DOI https://doi.org/10.1039/D2CC01170K
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Royal Society of Chemistry (UK)
publisher.none.fl_str_mv Royal Society of Chemistry (UK)
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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