Tianeptine, an atypical pharmacological approach to depression

The introduction of the first antidepressants in the 50s of the 20th century radically changed the treatment of depression, while providing information on pathophysiological aspects of this disease. New antidepressants drugs (agomelatine, tianeptine, vortioxetine) are providing data that give rise t...

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Autores: Álamo González, Cecilio Francisco|||0000-0001-7652-7931, García García, Pilar, López Muñoz, Francisco, Zaragozá Arnáez, Cristina|||0000-0002-4768-6797
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad de Alcalá (UAH)
Repositorio:e_Buah Biblioteca Digital Universidad de Alcalá
Idioma:inglés
OAI Identifier:oai:dnet:ebuahbibliot::547479db987668919ce887103839f63f
Acceso en línea:http://hdl.handle.net/10017/68918
https://dx.doi.org/10.1016/j.rpsm.2018.09.002
Access Level:acceso abierto
Palabra clave:Tianeptine
Depression
Pharmacology
Tianeptina
Depresión
Farmacología
Farmacia
Pharmacy
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spelling Tianeptine, an atypical pharmacological approach to depressionTianeptina, un abordaje farmacológico atípico de la depresiónÁlamo González, Cecilio Francisco|||0000-0001-7652-7931García García, PilarLópez Muñoz, FranciscoZaragozá Arnáez, Cristina|||0000-0002-4768-6797TianeptineDepressionPharmacologyTianeptinaDepresiónFarmacologíaFarmaciaPharmacyThe introduction of the first antidepressants in the 50s of the 20th century radically changed the treatment of depression, while providing information on pathophysiological aspects of this disease. New antidepressants drugs (agomelatine, tianeptine, vortioxetine) are providing data that give rise to pathophysiological hypotheses of depression that differ from the classic monoaminergic theory. In this sense, tianeptina, an atypical drug by its mechanism of differential action, contributes to clarify that in depression there is more than monoamines. Thus, tianeptine does not modify the rate of extracellular serotonin, so it does not increase or decrease the reuptake of serotonin. Chronic administration of tianeptine does not alter the density or affinity of more than a hundred classical receptors related to depression. Recently, a weak action of tianeptine on Mu opioid receptors has been described that could explain the release of dopamine in the limbic system and its participation in the modulation of glutamatergic mechanisms. These mechanisms support the hypothesis of the possible mechanism of action of this antidepressant. Tianeptine is an antidepressant, with anxiolytic properties, that can improve somatic symptoms. Tianeptine as a glutamatergic modulator, among other mechanisms, allows us to approach depression from a different point of view than other antidepressants.La introducción de los primeros antidepresivos en la década de los cincuenta del siglo xx modificó de forma radical el tratamiento de la depresión, a la vez que aportó información sobre aspectos fisiopatológicos de esta enfermedad. Los nuevos fármacos antidepresivos (agomelatina, tianeptina, vortioxetina) están aportando datos que dan lugar a hipótesis fisiopatológicas de la depresión que difieren de la clásica teoría monoaminérgica. En este sentido, la tianeptina, un fármaco atípico por su mecanismo de acción diferencial, contribuye a clarificar que en la fisiopatología de la depresión hay algo más que monoaminas. Así, la tianeptina no modifica la tasa de serotonina extracelular, por lo que no aumenta ni disminuye la recaptación de serotonina. La administración crónica de tianeptina no altera la densidad ni la afinidad de más de un centenar de receptores clásicos relacionados con la depresión. Recientemente se ha descrito una acción débil de la tianeptina sobre receptores opioides Mu que podría explicar la liberación de dopamina en el sistema límbico y su participación en la modulación de mecanismos glutamatérgicos. Estos mecanismos sustentan la hipótesis del posible mecanismo de acción de este antidepresivo. La tianeptina es un antidepresivo con propiedades ansiolíticas que puede mejorar síntomas somáticos. La tianeptina como modulador glutamatérgico, entre otros mecanismos, permite abordar la depresión desde un punto de vista diferente al del resto de antidepresivos.Elsevier20192019-07-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10017/68918https://dx.doi.org/10.1016/j.rpsm.2018.09.002reponame:e_Buah Biblioteca Digital Universidad de Alcaláinstname:Universidad de Alcalá (UAH)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:dnet:ebuahbibliot::547479db987668919ce887103839f63f2026-06-18T11:13:07Z
dc.title.none.fl_str_mv Tianeptine, an atypical pharmacological approach to depression
Tianeptina, un abordaje farmacológico atípico de la depresión
title Tianeptine, an atypical pharmacological approach to depression
spellingShingle Tianeptine, an atypical pharmacological approach to depression
Álamo González, Cecilio Francisco|||0000-0001-7652-7931
Tianeptine
Depression
Pharmacology
Tianeptina
Depresión
Farmacología
Farmacia
Pharmacy
title_short Tianeptine, an atypical pharmacological approach to depression
title_full Tianeptine, an atypical pharmacological approach to depression
title_fullStr Tianeptine, an atypical pharmacological approach to depression
title_full_unstemmed Tianeptine, an atypical pharmacological approach to depression
title_sort Tianeptine, an atypical pharmacological approach to depression
dc.creator.none.fl_str_mv Álamo González, Cecilio Francisco|||0000-0001-7652-7931
García García, Pilar
López Muñoz, Francisco
Zaragozá Arnáez, Cristina|||0000-0002-4768-6797
author Álamo González, Cecilio Francisco|||0000-0001-7652-7931
author_facet Álamo González, Cecilio Francisco|||0000-0001-7652-7931
García García, Pilar
López Muñoz, Francisco
Zaragozá Arnáez, Cristina|||0000-0002-4768-6797
author_role author
author2 García García, Pilar
López Muñoz, Francisco
Zaragozá Arnáez, Cristina|||0000-0002-4768-6797
author2_role author
author
author
dc.subject.none.fl_str_mv Tianeptine
Depression
Pharmacology
Tianeptina
Depresión
Farmacología
Farmacia
Pharmacy
topic Tianeptine
Depression
Pharmacology
Tianeptina
Depresión
Farmacología
Farmacia
Pharmacy
description The introduction of the first antidepressants in the 50s of the 20th century radically changed the treatment of depression, while providing information on pathophysiological aspects of this disease. New antidepressants drugs (agomelatine, tianeptine, vortioxetine) are providing data that give rise to pathophysiological hypotheses of depression that differ from the classic monoaminergic theory. In this sense, tianeptina, an atypical drug by its mechanism of differential action, contributes to clarify that in depression there is more than monoamines. Thus, tianeptine does not modify the rate of extracellular serotonin, so it does not increase or decrease the reuptake of serotonin. Chronic administration of tianeptine does not alter the density or affinity of more than a hundred classical receptors related to depression. Recently, a weak action of tianeptine on Mu opioid receptors has been described that could explain the release of dopamine in the limbic system and its participation in the modulation of glutamatergic mechanisms. These mechanisms support the hypothesis of the possible mechanism of action of this antidepressant. Tianeptine is an antidepressant, with anxiolytic properties, that can improve somatic symptoms. Tianeptine as a glutamatergic modulator, among other mechanisms, allows us to approach depression from a different point of view than other antidepressants.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-07-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10017/68918
https://dx.doi.org/10.1016/j.rpsm.2018.09.002
url http://hdl.handle.net/10017/68918
https://dx.doi.org/10.1016/j.rpsm.2018.09.002
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:e_Buah Biblioteca Digital Universidad de Alcalá
instname:Universidad de Alcalá (UAH)
instname_str Universidad de Alcalá (UAH)
reponame_str e_Buah Biblioteca Digital Universidad de Alcalá
collection e_Buah Biblioteca Digital Universidad de Alcalá
repository.name.fl_str_mv
repository.mail.fl_str_mv
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