Impact of apathy on health-related quality of life in recently diagnosed Parkinson's disease: The ANIMO study

The impact of apathy on health-related quality of life (HRQOL) in recently diagnosed Parkinson's disease (PD) has not been systematically investigated. The objective of this cross-sectional survey (ANIMO study) was to examine the contribution of apathy to HRQOL in a Spanish sample of recently d...

Full description

Bibliographic Details
Authors: Benito-Leon, J, Cubo, E, Coronell, C, Pascual-Sedano B., ANIMO Study Grp
Format: article
Status:Published version
Publication Date:2012
Country:España
Institution:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repository:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p11556
Online Access:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=11556
http://hdl.handle.net/10553/48392
Access Level:Open access
Keyword:apathy
Parkinson's disease
quality of life
EuroQol
Spain
id ES_eb3a789264f5a6dcf4de4b874c8df62f
oai_identifier_str oai:iibsantpau.fundanetsuite.com:p11556
network_acronym_str ES
network_name_str España
repository_id_str
spelling Impact of apathy on health-related quality of life in recently diagnosed Parkinson's disease: The ANIMO studyBenito-Leon, JCubo, ECoronell, CPascual-Sedano B.ANIMO Study GrpapathyParkinson's diseasequality of lifeEuroQolSpainThe impact of apathy on health-related quality of life (HRQOL) in recently diagnosed Parkinson's disease (PD) has not been systematically investigated. The objective of this cross-sectional survey (ANIMO study) was to examine the contribution of apathy to HRQOL in a Spanish sample of recently diagnosed PD patients. PD patients, diagnosed within 2 years of inclusion, were recruited at 102 outpatient clinics in 82 communities throughout Spain. Apathy was quantified using the Lille Apathy Rating Scale and HRQOL with the EuroQol-5D questionnaire. A mean EuroQol-5D index score of 0.89 obtained from population references in Spain was used as the cutoff for this study. The relationship between apathy and the dichotomized EuroQol-5D index score (<0.89 [lower HRQOL] vs =0.89 [reference]) was examined using multiple logistic regression analysis, adjusting for sociodemographic and clinical variables. We consecutively recruited 557 patients (60.3% men) with a mean age of 68.8 +/- 9.7 years. Apathy was diagnosed in 291 (52.2%) and was related to problems in each of the EuroQoL dimensions. Apathetic PD patients showed EuroQol-5D index scores significantly lower than those without apathy (0.64 vs 0.83). In an adjusted model, apathetic PD patients were 2.49 times more likely to have lower HRQOL than nonapathetic patients (odds ratio, 2.49; 95% confidence interval, 1.494.15, P < 0.01). Apathy is very common in those with recently diagnosed PD and is one of the major clinical determinants of HRQOL in this disease. It should be one of the primary concerns among clinicians who provide treatment to individuals affected by PD. (C) 2011 Movement Disorder SocietyWILEY2012info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=11556http://hdl.handle.net/10553/48392MOVEMENT DISORDERSISSN: 08853185ISSNe: 15318257reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p115562026-06-14T12:41:47Z
dc.title.none.fl_str_mv Impact of apathy on health-related quality of life in recently diagnosed Parkinson's disease: The ANIMO study
title Impact of apathy on health-related quality of life in recently diagnosed Parkinson's disease: The ANIMO study
spellingShingle Impact of apathy on health-related quality of life in recently diagnosed Parkinson's disease: The ANIMO study
Benito-Leon, J
apathy
Parkinson's disease
quality of life
EuroQol
Spain
title_short Impact of apathy on health-related quality of life in recently diagnosed Parkinson's disease: The ANIMO study
title_full Impact of apathy on health-related quality of life in recently diagnosed Parkinson's disease: The ANIMO study
title_fullStr Impact of apathy on health-related quality of life in recently diagnosed Parkinson's disease: The ANIMO study
title_full_unstemmed Impact of apathy on health-related quality of life in recently diagnosed Parkinson's disease: The ANIMO study
title_sort Impact of apathy on health-related quality of life in recently diagnosed Parkinson's disease: The ANIMO study
dc.creator.none.fl_str_mv Benito-Leon, J
Cubo, E
Coronell, C
Pascual-Sedano B.
ANIMO Study Grp
author Benito-Leon, J
author_facet Benito-Leon, J
Cubo, E
Coronell, C
Pascual-Sedano B.
ANIMO Study Grp
author_role author
author2 Cubo, E
Coronell, C
Pascual-Sedano B.
ANIMO Study Grp
author2_role author
author
author
author
dc.subject.none.fl_str_mv apathy
Parkinson's disease
quality of life
EuroQol
Spain
topic apathy
Parkinson's disease
quality of life
EuroQol
Spain
description The impact of apathy on health-related quality of life (HRQOL) in recently diagnosed Parkinson's disease (PD) has not been systematically investigated. The objective of this cross-sectional survey (ANIMO study) was to examine the contribution of apathy to HRQOL in a Spanish sample of recently diagnosed PD patients. PD patients, diagnosed within 2 years of inclusion, were recruited at 102 outpatient clinics in 82 communities throughout Spain. Apathy was quantified using the Lille Apathy Rating Scale and HRQOL with the EuroQol-5D questionnaire. A mean EuroQol-5D index score of 0.89 obtained from population references in Spain was used as the cutoff for this study. The relationship between apathy and the dichotomized EuroQol-5D index score (<0.89 [lower HRQOL] vs =0.89 [reference]) was examined using multiple logistic regression analysis, adjusting for sociodemographic and clinical variables. We consecutively recruited 557 patients (60.3% men) with a mean age of 68.8 +/- 9.7 years. Apathy was diagnosed in 291 (52.2%) and was related to problems in each of the EuroQoL dimensions. Apathetic PD patients showed EuroQol-5D index scores significantly lower than those without apathy (0.64 vs 0.83). In an adjusted model, apathetic PD patients were 2.49 times more likely to have lower HRQOL than nonapathetic patients (odds ratio, 2.49; 95% confidence interval, 1.494.15, P < 0.01). Apathy is very common in those with recently diagnosed PD and is one of the major clinical determinants of HRQOL in this disease. It should be one of the primary concerns among clinicians who provide treatment to individuals affected by PD. (C) 2011 Movement Disorder Society
publishDate 2012
dc.date.none.fl_str_mv 2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=11556
http://hdl.handle.net/10553/48392
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=11556
http://hdl.handle.net/10553/48392
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv WILEY
publisher.none.fl_str_mv WILEY
dc.source.none.fl_str_mv MOVEMENT DISORDERS
ISSN: 08853185
ISSNe: 15318257
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869423209415180288
score 15,811543

Similar Items