The cold-sensing ion channel TRPM8 regulates central and peripheral clockwork and the circadian oscillations of body temperature

[Aim] Physiological functions in mammals show circadian oscillations, synchronized by daily cycles of light and temperature. Central and peripheral clocks participate in this regulation. Since the ion channel TRPM8 is a critical cold sensor, we investigated its role in circadian function.

Detalles Bibliográficos
Autores: Reimúndez, Alfonso, Fernández-Peña, Carlos, Ordas, Purificación, Hernández-Ortego, Pablo, Gallego, Rosalía, Morenilla-Palao, Cruz, Navarro, Juan, Martín-Cora, Francisco, Pardo-Vázquez, José Luís, Schwarz, Lindsay A., Arce, Victor, Viana, Félix, Señarís, Rosa
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/304488
Acceso en línea:http://hdl.handle.net/10261/304488
https://api.elsevier.com/content/abstract/scopus_id/85141203411
Access Level:acceso abierto
Palabra clave:TRPM8
body temperature
central and peripheral clocks
circadian regulation
sensory physiology
Descripción
Sumario:[Aim] Physiological functions in mammals show circadian oscillations, synchronized by daily cycles of light and temperature. Central and peripheral clocks participate in this regulation. Since the ion channel TRPM8 is a critical cold sensor, we investigated its role in circadian function.

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