p38 activation occurs mainly in microglia in the P301S Tauopathy mouse model

Tauopathies are a group of neurodegenerative diseases characterized by the accumulation of hyperphosphorylated tau protein in the brain. Many of these pathologies also present an inflammatory component determined by the activation of microglia, the resident immune cells of the brain. p38 MAPK is one...

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Autores: Perea, Juan R., García, Esther, Vallés-Saiz, Laura, Cuadros, Raquel, Hernández Pérez, Félix, Bolós, Marta, Ávila, Jesús
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/719204
Acceso en línea:http://hdl.handle.net/10486/719204
https://dx.doi.org/10.1038/s41598-022-05980-8
Access Level:acceso abierto
Palabra clave:Tauopathies
p38 mitogen-activated protein kinases
Microglia
Alzheimer's disease
Hippocampus
Biología y Biomedicina / Biología
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spelling p38 activation occurs mainly in microglia in the P301S Tauopathy mouse modelPerea, Juan R.García, EstherVallés-Saiz, LauraCuadros, RaquelHernández Pérez, FélixBolós, MartaÁvila, JesúsTauopathiesp38 mitogen-activated protein kinasesMicrogliaAlzheimer's diseaseHippocampusBiología y Biomedicina / BiologíaTauopathies are a group of neurodegenerative diseases characterized by the accumulation of hyperphosphorylated tau protein in the brain. Many of these pathologies also present an inflammatory component determined by the activation of microglia, the resident immune cells of the brain. p38 MAPK is one of the molecular pathways involved in neuroinflammation. Although this kinase is expressed mainly in glia, its activation in certain neurodegenerative diseases such as Alzheimer's Disease has been associated with its ability to phosphorylate tau in neurons. Using the P301S Tauopathy mouse model, here we show that p38 activation increases during aging and that this occurs mainly in microglia of the hippocampus rather than in neurons. Furthermore, we have observed that these mice present an activated microglial variant called rod microglia. Interestingly, p38 activation in this subpopulation of microglia is decreased. On the basis of our findings, we propose that rod microglia might have a neuroprotective phenotype in the context of tau pathologyThis research was funded by the Spanish Ministry of Science and Innovation (BES-2015-074405, PGC2018-096177-B-I00), the Center for Networked Biomedical Research on Neurodegenerative Diseases, and the Comunidad de Madrid (S2017/BMD). Institutional grants from the Fundación Ramón Areces and Banco de Santander are also acknowledged. The authors would like to thank the confocal microscopy facility at CBMSO for technical assistance, and Dr. Peter Davies for the donation of the phospho-Tau antibody (PHF-1)Nature ResearchDepartamento de Biología MolecularFacultad de Ciencias20222022-02-08research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/719204https://dx.doi.org/10.1038/s41598-022-05980-8reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/7192042026-06-23T12:46:27Z
dc.title.none.fl_str_mv p38 activation occurs mainly in microglia in the P301S Tauopathy mouse model
title p38 activation occurs mainly in microglia in the P301S Tauopathy mouse model
spellingShingle p38 activation occurs mainly in microglia in the P301S Tauopathy mouse model
Perea, Juan R.
Tauopathies
p38 mitogen-activated protein kinases
Microglia
Alzheimer's disease
Hippocampus
Biología y Biomedicina / Biología
title_short p38 activation occurs mainly in microglia in the P301S Tauopathy mouse model
title_full p38 activation occurs mainly in microglia in the P301S Tauopathy mouse model
title_fullStr p38 activation occurs mainly in microglia in the P301S Tauopathy mouse model
title_full_unstemmed p38 activation occurs mainly in microglia in the P301S Tauopathy mouse model
title_sort p38 activation occurs mainly in microglia in the P301S Tauopathy mouse model
dc.creator.none.fl_str_mv Perea, Juan R.
García, Esther
Vallés-Saiz, Laura
Cuadros, Raquel
Hernández Pérez, Félix
Bolós, Marta
Ávila, Jesús
author Perea, Juan R.
author_facet Perea, Juan R.
García, Esther
Vallés-Saiz, Laura
Cuadros, Raquel
Hernández Pérez, Félix
Bolós, Marta
Ávila, Jesús
author_role author
author2 García, Esther
Vallés-Saiz, Laura
Cuadros, Raquel
Hernández Pérez, Félix
Bolós, Marta
Ávila, Jesús
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Biología Molecular
Facultad de Ciencias
dc.subject.none.fl_str_mv Tauopathies
p38 mitogen-activated protein kinases
Microglia

Alzheimer's disease
Hippocampus
Biología y Biomedicina / Biología
topic Tauopathies
p38 mitogen-activated protein kinases
Microglia
Alzheimer's disease
Hippocampus
Biología y Biomedicina / Biología
description Tauopathies are a group of neurodegenerative diseases characterized by the accumulation of hyperphosphorylated tau protein in the brain. Many of these pathologies also present an inflammatory component determined by the activation of microglia, the resident immune cells of the brain. p38 MAPK is one of the molecular pathways involved in neuroinflammation. Although this kinase is expressed mainly in glia, its activation in certain neurodegenerative diseases such as Alzheimer's Disease has been associated with its ability to phosphorylate tau in neurons. Using the P301S Tauopathy mouse model, here we show that p38 activation increases during aging and that this occurs mainly in microglia of the hippocampus rather than in neurons. Furthermore, we have observed that these mice present an activated microglial variant called rod microglia. Interestingly, p38 activation in this subpopulation of microglia is decreased. On the basis of our findings, we propose that rod microglia might have a neuroprotective phenotype in the context of tau pathology
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-02-08
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/719204
https://dx.doi.org/10.1038/s41598-022-05980-8
url http://hdl.handle.net/10486/719204
https://dx.doi.org/10.1038/s41598-022-05980-8
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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