Semaphorin 3C exacerbates liver fibrosis.
Chronic liver disease is a growing epidemic, leading to fibrosis and cirrhosis. TGF-ß is the pivotal profibrogenic cytokine that activates HSC, yet other molecules can modulate TGF-ß signaling during liver fibrosis. Expression of the axon guidance molecules semaphorins (SEMAs), which signal through...
| Autores: | , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Centro de Investigación Principe Felipe (CIPF) |
| Repositorio: | r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF) |
| OAI Identifier: | oai:cipf.fundanetsuite.com:p4088 |
| Acceso en línea: | https://cipf.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4088 |
| Access Level: | acceso abierto |
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Semaphorin 3C exacerbates liver fibrosis.De Angelis Rigotti FWiedmann LHubert MOVacca MHasan SSMoll ICarvajal SJiménez WStarostecka MBilleter ATMüller-Stich BWolff GEkim-Üstünel BHerzig SFandos-Ramo CKrätzner RReich MKeitel-Anselmino VHeikenwälder MMogler CFischer ARodriguez-Vita JChronic liver disease is a growing epidemic, leading to fibrosis and cirrhosis. TGF-ß is the pivotal profibrogenic cytokine that activates HSC, yet other molecules can modulate TGF-ß signaling during liver fibrosis. Expression of the axon guidance molecules semaphorins (SEMAs), which signal through plexins and neuropilins (NRPs), have been associated with liver fibrosis in HBV-induced chronic hepatitis. This study aims at determining their function in the regulation of HSCs.LIPPINCOTT WILLIAMS & WILKINS2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://cipf.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4088HEPATOLOGYISSN: 02709139ISSNe: 15273350reponame:r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)instname:Centro de Investigación Principe Felipe (CIPF)Inglésinfo:eu-repo/semantics/openAccessoai:cipf.fundanetsuite.com:p40882026-06-17T11:19:47Z |
| dc.title.none.fl_str_mv |
Semaphorin 3C exacerbates liver fibrosis. |
| title |
Semaphorin 3C exacerbates liver fibrosis. |
| spellingShingle |
Semaphorin 3C exacerbates liver fibrosis. De Angelis Rigotti F |
| title_short |
Semaphorin 3C exacerbates liver fibrosis. |
| title_full |
Semaphorin 3C exacerbates liver fibrosis. |
| title_fullStr |
Semaphorin 3C exacerbates liver fibrosis. |
| title_full_unstemmed |
Semaphorin 3C exacerbates liver fibrosis. |
| title_sort |
Semaphorin 3C exacerbates liver fibrosis. |
| dc.creator.none.fl_str_mv |
De Angelis Rigotti F Wiedmann L Hubert MO Vacca M Hasan SS Moll I Carvajal S Jiménez W Starostecka M Billeter AT Müller-Stich B Wolff G Ekim-Üstünel B Herzig S Fandos-Ramo C Krätzner R Reich M Keitel-Anselmino V Heikenwälder M Mogler C Fischer A Rodriguez-Vita J |
| author |
De Angelis Rigotti F |
| author_facet |
De Angelis Rigotti F Wiedmann L Hubert MO Vacca M Hasan SS Moll I Carvajal S Jiménez W Starostecka M Billeter AT Müller-Stich B Wolff G Ekim-Üstünel B Herzig S Fandos-Ramo C Krätzner R Reich M Keitel-Anselmino V Heikenwälder M Mogler C Fischer A Rodriguez-Vita J |
| author_role |
author |
| author2 |
Wiedmann L Hubert MO Vacca M Hasan SS Moll I Carvajal S Jiménez W Starostecka M Billeter AT Müller-Stich B Wolff G Ekim-Üstünel B Herzig S Fandos-Ramo C Krätzner R Reich M Keitel-Anselmino V Heikenwälder M Mogler C Fischer A Rodriguez-Vita J |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author |
| description |
Chronic liver disease is a growing epidemic, leading to fibrosis and cirrhosis. TGF-ß is the pivotal profibrogenic cytokine that activates HSC, yet other molecules can modulate TGF-ß signaling during liver fibrosis. Expression of the axon guidance molecules semaphorins (SEMAs), which signal through plexins and neuropilins (NRPs), have been associated with liver fibrosis in HBV-induced chronic hepatitis. This study aims at determining their function in the regulation of HSCs. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://cipf.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4088 |
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https://cipf.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4088 |
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Inglés |
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Inglés |
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info:eu-repo/semantics/openAccess |
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openAccess |
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LIPPINCOTT WILLIAMS & WILKINS |
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LIPPINCOTT WILLIAMS & WILKINS |
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HEPATOLOGY ISSN: 02709139 ISSNe: 15273350 reponame:r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF) instname:Centro de Investigación Principe Felipe (CIPF) |
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Centro de Investigación Principe Felipe (CIPF) |
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r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF) |
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r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF) |
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15,81155 |