Circadian-related heteromerization of adrenergic and dopamine D4 receptors modulates melatonin synthesis and release in the pineal gland

González, Sergio; Moreno Delgado, David|||0000-0003-0070-2566; Moreno, Estefanía|||0000-0002-2491-5753; Pérez-Capote, Kamil; Franco, Rafael|||0000-0003-2549-4919; Mallol, Josefa; Cortés, Antoni; Casadó, Vicent|||0000-0002-1764-3825; Lluís, Carme; Ortiz de Pablo, Jordi|||0000-0002-9748-2290; Ferré, Sergi|||0000-0002-1747-1779; Canela, Enric I|||0000-0003-4992-7440; McCormick, Peter J.

Circadian-related heteromerization of adrenergic and dopamine D4 receptors modulates melatonin synthesis and release in the pineal gland

The role of the pineal gland is to translate the rhythmic cycles of night and day encoded by the retina into hormonal signals that are transmitted to the rest of the neuronal system in the form of serotonin and melatonin synthesis and release. Here we describe that the production of both melatonin a...

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Authors:	González, Sergio, Moreno Delgado, David\|\|\|0000-0003-0070-2566, Moreno, Estefanía\|\|\|0000-0002-2491-5753, Pérez-Capote, Kamil, Franco, Rafael\|\|\|0000-0003-2549-4919, Mallol, Josefa, Cortés, Antoni, Casadó, Vicent\|\|\|0000-0002-1764-3825, Lluís, Carme, Ortiz de Pablo, Jordi\|\|\|0000-0002-9748-2290, Ferré, Sergi\|\|\|0000-0002-1747-1779, Canela, Enric I\|\|\|0000-0003-4992-7440, McCormick, Peter J.
Format:	article
Publication Date:	2012
Country:	España
Institution:	Universitat Autònoma de Barcelona
Repository:	Dipòsit Digital de Documents de la UAB
Language:	English
OAI Identifier:	oai:ddd.uab.cat:112583
Online Access:	https://ddd.uab.cat/record/112583 https://dx.doi.org/urn:doi:10.1371/journal.pbio.1001347
Access Level:	Open access
Keyword:	Melatonin Dopamine Co-immunoprecipitation Immune receptors Membrane receptor signaling Immunoprecipitation Pineal gland

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network_acronym_str	ES
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spelling	Circadian-related heteromerization of adrenergic and dopamine D4 receptors modulates melatonin synthesis and release in the pineal glandGonzález, SergioMoreno Delgado, David\|\|\|0000-0003-0070-2566Moreno, Estefanía\|\|\|0000-0002-2491-5753Pérez-Capote, KamilFranco, Rafael\|\|\|0000-0003-2549-4919Mallol, JosefaCortés, AntoniCasadó, Vicent\|\|\|0000-0002-1764-3825Lluís, CarmeOrtiz de Pablo, Jordi\|\|\|0000-0002-9748-2290Ferré, Sergi\|\|\|0000-0002-1747-1779Canela, Enric I\|\|\|0000-0003-4992-7440McCormick, Peter J.MelatoninDopamineCo-immunoprecipitationImmune receptorsMembrane receptor signalingImmunoprecipitationPineal glandThe role of the pineal gland is to translate the rhythmic cycles of night and day encoded by the retina into hormonal signals that are transmitted to the rest of the neuronal system in the form of serotonin and melatonin synthesis and release. Here we describe that the production of both melatonin and serotonin by the pineal gland is regulated by a circadian-related heteromerization of adrenergic and dopamine D4 receptors. Through α1B-D4 and β1-D4 receptor heteromers dopamine inhibits adrenergic receptor signaling and blocks the synthesis of melatonin induced by adrenergic receptor ligands. This inhibition was not observed at hours of the day when D4 was not expressed. These data provide a new perspective on dopamine function and constitute the first example of a circadian-controlled receptor heteromer. The unanticipated heteromerization between adrenergic and dopamine D4 receptors provides a feedback mechanism for the neuronal hormone system in the form of dopamine to control circadian inputs. 22012-01-0120122012-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/112583https://dx.doi.org/urn:doi:10.1371/journal.pbio.1001347reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/2.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:1125832026-06-06T12:50:31Z
dc.title.none.fl_str_mv	Circadian-related heteromerization of adrenergic and dopamine D4 receptors modulates melatonin synthesis and release in the pineal gland
title	Circadian-related heteromerization of adrenergic and dopamine D4 receptors modulates melatonin synthesis and release in the pineal gland
spellingShingle	Circadian-related heteromerization of adrenergic and dopamine D4 receptors modulates melatonin synthesis and release in the pineal gland González, Sergio Melatonin Dopamine Co-immunoprecipitation Immune receptors Membrane receptor signaling Immunoprecipitation Pineal gland
title_short	Circadian-related heteromerization of adrenergic and dopamine D4 receptors modulates melatonin synthesis and release in the pineal gland
title_full	Circadian-related heteromerization of adrenergic and dopamine D4 receptors modulates melatonin synthesis and release in the pineal gland
title_fullStr	Circadian-related heteromerization of adrenergic and dopamine D4 receptors modulates melatonin synthesis and release in the pineal gland
title_full_unstemmed	Circadian-related heteromerization of adrenergic and dopamine D4 receptors modulates melatonin synthesis and release in the pineal gland
title_sort	Circadian-related heteromerization of adrenergic and dopamine D4 receptors modulates melatonin synthesis and release in the pineal gland
dc.creator.none.fl_str_mv	González, Sergio Moreno Delgado, David\|\|\|0000-0003-0070-2566 Moreno, Estefanía\|\|\|0000-0002-2491-5753 Pérez-Capote, Kamil Franco, Rafael\|\|\|0000-0003-2549-4919 Mallol, Josefa Cortés, Antoni Casadó, Vicent\|\|\|0000-0002-1764-3825 Lluís, Carme Ortiz de Pablo, Jordi\|\|\|0000-0002-9748-2290 Ferré, Sergi\|\|\|0000-0002-1747-1779 Canela, Enric I\|\|\|0000-0003-4992-7440 McCormick, Peter J.
author	González, Sergio
author_facet	González, Sergio Moreno Delgado, David\|\|\|0000-0003-0070-2566 Moreno, Estefanía\|\|\|0000-0002-2491-5753 Pérez-Capote, Kamil Franco, Rafael\|\|\|0000-0003-2549-4919 Mallol, Josefa Cortés, Antoni Casadó, Vicent\|\|\|0000-0002-1764-3825 Lluís, Carme Ortiz de Pablo, Jordi\|\|\|0000-0002-9748-2290 Ferré, Sergi\|\|\|0000-0002-1747-1779 Canela, Enric I\|\|\|0000-0003-4992-7440 McCormick, Peter J.
author_role	author
author2	Moreno Delgado, David\|\|\|0000-0003-0070-2566 Moreno, Estefanía\|\|\|0000-0002-2491-5753 Pérez-Capote, Kamil Franco, Rafael\|\|\|0000-0003-2549-4919 Mallol, Josefa Cortés, Antoni Casadó, Vicent\|\|\|0000-0002-1764-3825 Lluís, Carme Ortiz de Pablo, Jordi\|\|\|0000-0002-9748-2290 Ferré, Sergi\|\|\|0000-0002-1747-1779 Canela, Enric I\|\|\|0000-0003-4992-7440 McCormick, Peter J.
author2_role	author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Melatonin Dopamine Co-immunoprecipitation Immune receptors Membrane receptor signaling Immunoprecipitation Pineal gland
topic	Melatonin Dopamine Co-immunoprecipitation Immune receptors Membrane receptor signaling Immunoprecipitation Pineal gland
description	The role of the pineal gland is to translate the rhythmic cycles of night and day encoded by the retina into hormonal signals that are transmitted to the rest of the neuronal system in the form of serotonin and melatonin synthesis and release. Here we describe that the production of both melatonin and serotonin by the pineal gland is regulated by a circadian-related heteromerization of adrenergic and dopamine D4 receptors. Through α1B-D4 and β1-D4 receptor heteromers dopamine inhibits adrenergic receptor signaling and blocks the synthesis of melatonin induced by adrenergic receptor ligands. This inhibition was not observed at hours of the day when D4 was not expressed. These data provide a new perspective on dopamine function and constitute the first example of a circadian-controlled receptor heteromer. The unanticipated heteromerization between adrenergic and dopamine D4 receptors provides a feedback mechanism for the neuronal hormone system in the form of dopamine to control circadian inputs.
publishDate	2012
dc.date.none.fl_str_mv	2 2012-01-01 2012 2012-01-01
dc.type.none.fl_str_mv	Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://ddd.uab.cat/record/112583 https://dx.doi.org/urn:doi:10.1371/journal.pbio.1001347
url	https://ddd.uab.cat/record/112583 https://dx.doi.org/urn:doi:10.1371/journal.pbio.1001347
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/2.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/2.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.source.none.fl_str_mv	reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona
instname_str	Universitat Autònoma de Barcelona
reponame_str	Dipòsit Digital de Documents de la UAB
collection	Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Circadian-related heteromerization of adrenergic and dopamine D4 receptors modulates melatonin synthesis and release in the pineal gland

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