Loading of antibiotic into biocoated hydroxyapatite nanoparticles: smart antitumor platforms with regulated release

In this research we propose a nanoplatform for anticancer therapy that is based on the combination of three components: (1) an antibiotic to target selectively the mitochondria of cancer cells, inhibiting their functions; (2) mineral nanoparticles (NPs) able to encapsulate the antibiotic and to ente...

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Autores: Rivas Cañas, Manuel|||0000-0002-8884-3410, Valle Mendoza, Luis Javier del|||0000-0001-9916-1741, Rodríguez Rivero, Anna M., Turon, Pau, Puiggalí Bellalta, Jordi|||0000-0002-0640-4474, Alemán Llansó, Carlos|||0000-0003-4462-6075
Formato: artículo
Fecha de publicación:2018
País:España
Recursos:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/130946
Acesso em linha:https://hdl.handle.net/2117/130946
https://dx.doi.org/10.1021/acsbiomaterials.8b00353
Access Level:acceso abierto
Palavra-chave:Antibiotics
Cancer
Calcium phosphate
Chloramphenicol
Cancer cells
antibiotic
biocoating
calcium phosphate
cancer cells
chloramphenicol
polyphosphate
Antibiòtics
Càncer
Fosfat de calci
Cèl·lules canceroses
Cloramfenicol
Àrees temàtiques de la UPC::Enginyeria química
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network_acronym_str ES
network_name_str España
repository_id_str
spelling Loading of antibiotic into biocoated hydroxyapatite nanoparticles: smart antitumor platforms with regulated releaseRivas Cañas, Manuel|||0000-0002-8884-3410Valle Mendoza, Luis Javier del|||0000-0001-9916-1741Rodríguez Rivero, Anna M.Turon, PauPuiggalí Bellalta, Jordi|||0000-0002-0640-4474Alemán Llansó, Carlos|||0000-0003-4462-6075AntibioticsCancerCalcium phosphateChloramphenicolCancer cellsantibioticbiocoatingcalcium phosphatecancer cellschloramphenicolpolyphosphateAntibiòticsCàncerFosfat de calciCèl·lules cancerosesCloramfenicolÀrees temàtiques de la UPC::Enginyeria químicaIn this research we propose a nanoplatform for anticancer therapy that is based on the combination of three components: (1) an antibiotic to target selectively the mitochondria of cancer cells, inhibiting their functions; (2) mineral nanoparticles (NPs) able to encapsulate the antibiotic and to enter into the cells across the cell membrane; and (3) a biocoating to protect the antibiotic during and/or after its regulated release, increasing its therapeutic efficacy. Chloramphenicol (CAM), a prototypical wide-spectrum antibiotic, has been used to induce mitochondrial-dysfunctions in cancer cells. Different in situ synthetic strategies have been tested to load such antibiotic into both crystalline hydroxyapatite (cHAp) and amorphous calcium phosphate (ACP) NPs. cHAp NPs showed higher loading capacity, in terms of encapsulation and superficial adsorption of CAM, and slower antibiotic release than ACP NPs. On the other hand, the protecting role played by biocoatings based on pyrophosphate and, especially, triphosphate was greater than that of biophosphonates, the anticancer therapeutic efficacy of CAM being maximized by the former. In vitro studies using healthy and cancer cell lines have demonstrated that in situ CAM-loaded cHAp NPs coated with triphosphate selectively kill a great population of cancer cells, evidencing the potential of this nanoplatform in cancer treatment.Peer ReviewedAmerican Chemical Society (ACS)20182018-07-2620192019-03-27journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/130946https://dx.doi.org/10.1021/acsbiomaterials.8b00353reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)InglésengMinisterio de Economía y Competitividad http://doi.org/10.13039/501100003329 MAT2015-69547-R MICROPIEZAS BASADAS EN POLIESTERAMIDAS BIODEGRADABLES CARGADAS CON BACTERIOFAGOS Y BIOMOLECULAS SUSCEPTIBLES A PROCESOS DE DESNATURALIZACION: APLICACIONES EN BIOMEDICINAMinisterio de Economía y Competitividad http://doi.org/10.13039/501100003329 MAT2015-69367-R PIEL ELECTRONICA INTELIGENTEopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivs 3.0 Spainhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/1309462026-05-27T15:37:01Z
dc.title.none.fl_str_mv Loading of antibiotic into biocoated hydroxyapatite nanoparticles: smart antitumor platforms with regulated release
title Loading of antibiotic into biocoated hydroxyapatite nanoparticles: smart antitumor platforms with regulated release
spellingShingle Loading of antibiotic into biocoated hydroxyapatite nanoparticles: smart antitumor platforms with regulated release
Rivas Cañas, Manuel|||0000-0002-8884-3410
Antibiotics
Cancer
Calcium phosphate
Chloramphenicol
Cancer cells
antibiotic
biocoating
calcium phosphate
cancer cells
chloramphenicol
polyphosphate
Antibiòtics
Càncer
Fosfat de calci
Cèl·lules canceroses
Cloramfenicol
Àrees temàtiques de la UPC::Enginyeria química
title_short Loading of antibiotic into biocoated hydroxyapatite nanoparticles: smart antitumor platforms with regulated release
title_full Loading of antibiotic into biocoated hydroxyapatite nanoparticles: smart antitumor platforms with regulated release
title_fullStr Loading of antibiotic into biocoated hydroxyapatite nanoparticles: smart antitumor platforms with regulated release
title_full_unstemmed Loading of antibiotic into biocoated hydroxyapatite nanoparticles: smart antitumor platforms with regulated release
title_sort Loading of antibiotic into biocoated hydroxyapatite nanoparticles: smart antitumor platforms with regulated release
dc.creator.none.fl_str_mv Rivas Cañas, Manuel|||0000-0002-8884-3410
Valle Mendoza, Luis Javier del|||0000-0001-9916-1741
Rodríguez Rivero, Anna M.
Turon, Pau
Puiggalí Bellalta, Jordi|||0000-0002-0640-4474
Alemán Llansó, Carlos|||0000-0003-4462-6075
author Rivas Cañas, Manuel|||0000-0002-8884-3410
author_facet Rivas Cañas, Manuel|||0000-0002-8884-3410
Valle Mendoza, Luis Javier del|||0000-0001-9916-1741
Rodríguez Rivero, Anna M.
Turon, Pau
Puiggalí Bellalta, Jordi|||0000-0002-0640-4474
Alemán Llansó, Carlos|||0000-0003-4462-6075
author_role author
author2 Valle Mendoza, Luis Javier del|||0000-0001-9916-1741
Rodríguez Rivero, Anna M.
Turon, Pau
Puiggalí Bellalta, Jordi|||0000-0002-0640-4474
Alemán Llansó, Carlos|||0000-0003-4462-6075
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Antibiotics
Cancer
Calcium phosphate
Chloramphenicol
Cancer cells
antibiotic
biocoating
calcium phosphate
cancer cells
chloramphenicol
polyphosphate
Antibiòtics
Càncer
Fosfat de calci
Cèl·lules canceroses
Cloramfenicol
Àrees temàtiques de la UPC::Enginyeria química
topic Antibiotics
Cancer
Calcium phosphate
Chloramphenicol
Cancer cells
antibiotic
biocoating
calcium phosphate
cancer cells
chloramphenicol
polyphosphate
Antibiòtics
Càncer
Fosfat de calci
Cèl·lules canceroses
Cloramfenicol
Àrees temàtiques de la UPC::Enginyeria química
description In this research we propose a nanoplatform for anticancer therapy that is based on the combination of three components: (1) an antibiotic to target selectively the mitochondria of cancer cells, inhibiting their functions; (2) mineral nanoparticles (NPs) able to encapsulate the antibiotic and to enter into the cells across the cell membrane; and (3) a biocoating to protect the antibiotic during and/or after its regulated release, increasing its therapeutic efficacy. Chloramphenicol (CAM), a prototypical wide-spectrum antibiotic, has been used to induce mitochondrial-dysfunctions in cancer cells. Different in situ synthetic strategies have been tested to load such antibiotic into both crystalline hydroxyapatite (cHAp) and amorphous calcium phosphate (ACP) NPs. cHAp NPs showed higher loading capacity, in terms of encapsulation and superficial adsorption of CAM, and slower antibiotic release than ACP NPs. On the other hand, the protecting role played by biocoatings based on pyrophosphate and, especially, triphosphate was greater than that of biophosphonates, the anticancer therapeutic efficacy of CAM being maximized by the former. In vitro studies using healthy and cancer cell lines have demonstrated that in situ CAM-loaded cHAp NPs coated with triphosphate selectively kill a great population of cancer cells, evidencing the potential of this nanoplatform in cancer treatment.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-07-26
2019
2019-03-27
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/130946
https://dx.doi.org/10.1021/acsbiomaterials.8b00353
url https://hdl.handle.net/2117/130946
https://dx.doi.org/10.1021/acsbiomaterials.8b00353
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Economía y Competitividad http://doi.org/10.13039/501100003329 MAT2015-69547-R MICROPIEZAS BASADAS EN POLIESTERAMIDAS BIODEGRADABLES CARGADAS CON BACTERIOFAGOS Y BIOMOLECULAS SUSCEPTIBLES A PROCESOS DE DESNATURALIZACION: APLICACIONES EN BIOMEDICINA
Ministerio de Economía y Competitividad http://doi.org/10.13039/501100003329 MAT2015-69367-R PIEL ELECTRONICA INTELIGENTE
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Chemical Society (ACS)
publisher.none.fl_str_mv American Chemical Society (ACS)
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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