Connecting the retina to the brain

The visual system is beautifully crafted to transmit information of the external world to visual processing and cognitivecenters in the brain. For visual information to be relayed to the brain, a series of axon pathfinding events must take place toensure that the axons of retinal ganglion cells, the...

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Detalles Bibliográficos
Autores: Erskine, Lynda, Herrera, Eloisa
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/289378
Acceso en línea:http://hdl.handle.net/10261/289378
Access Level:acceso abierto
Palabra clave:Axon guidance
Growth cone
Optic chiasm
Retinal ganglion cell
Topographic mapping
Visual system
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spelling Connecting the retina to the brainErskine, LyndaHerrera, EloisaAxon guidanceGrowth coneOptic chiasmRetinal ganglion cellTopographic mappingVisual systemThe visual system is beautifully crafted to transmit information of the external world to visual processing and cognitivecenters in the brain. For visual information to be relayed to the brain, a series of axon pathfinding events must take place toensure that the axons of retinal ganglion cells, the only neuronal cell type in the retina that sends axons out of the retina, findtheir way out of the eye to connect with targets in the brain. In the past few decades, the power of molecular and genetictools, including the generation of genetically manipulated mouse lines, have multiplied our knowledge about the molecularmechanisms involved in the sculpting of the visual system. Here, we review major advances in our understanding of themechanisms controlling the differentiation of RGCs, guidance of their axons from the retina to the primary visual centers,and the refinement processes essential for the establishment of topographic maps and eye-specific axon segregation. Humandisorders, such as albinism and achiasmia, that impair RGC axon growth and guidance and, thus, the establishment of a fullyfunctioning visual system will also be discussed.Work inthe laboratory of LE is funded by the BBSRC [BB/J00815X/1] andthe R.S. Macdonald Charitable Trust. Research in the laboratory of EH is funded by grants from the Regional Government [Prometeo2012-005], the Spanish Ministry of Economy and Competitiveness [BFU2010-16563] and the European Research Council [ERC2011-StG20101109].Peer reviewedSage PublicationsBiotechnology and Biological Sciences Research Council (UK)European Research CouncilGeneralitat ValencianaMinisterio de Economía y Competitividad (España)Ministerio de Ciencia e Innovación (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202320232014info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/289378reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MICINN//BFU2010-16563ASN Neurohttps://doi.org/10.1177/1759091414562107Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2893782026-05-22T06:33:51Z
dc.title.none.fl_str_mv Connecting the retina to the brain
title Connecting the retina to the brain
spellingShingle Connecting the retina to the brain
Erskine, Lynda
Axon guidance
Growth cone
Optic chiasm
Retinal ganglion cell
Topographic mapping
Visual system
title_short Connecting the retina to the brain
title_full Connecting the retina to the brain
title_fullStr Connecting the retina to the brain
title_full_unstemmed Connecting the retina to the brain
title_sort Connecting the retina to the brain
dc.creator.none.fl_str_mv Erskine, Lynda
Herrera, Eloisa
author Erskine, Lynda
author_facet Erskine, Lynda
Herrera, Eloisa
author_role author
author2 Herrera, Eloisa
author2_role author
dc.contributor.none.fl_str_mv Biotechnology and Biological Sciences Research Council (UK)
European Research Council
Generalitat Valenciana
Ministerio de Economía y Competitividad (España)
Ministerio de Ciencia e Innovación (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Axon guidance
Growth cone
Optic chiasm
Retinal ganglion cell
Topographic mapping
Visual system
topic Axon guidance
Growth cone
Optic chiasm
Retinal ganglion cell
Topographic mapping
Visual system
description The visual system is beautifully crafted to transmit information of the external world to visual processing and cognitivecenters in the brain. For visual information to be relayed to the brain, a series of axon pathfinding events must take place toensure that the axons of retinal ganglion cells, the only neuronal cell type in the retina that sends axons out of the retina, findtheir way out of the eye to connect with targets in the brain. In the past few decades, the power of molecular and genetictools, including the generation of genetically manipulated mouse lines, have multiplied our knowledge about the molecularmechanisms involved in the sculpting of the visual system. Here, we review major advances in our understanding of themechanisms controlling the differentiation of RGCs, guidance of their axons from the retina to the primary visual centers,and the refinement processes essential for the establishment of topographic maps and eye-specific axon segregation. Humandisorders, such as albinism and achiasmia, that impair RGC axon growth and guidance and, thus, the establishment of a fullyfunctioning visual system will also be discussed.
publishDate 2014
dc.date.none.fl_str_mv 2014
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/289378
url http://hdl.handle.net/10261/289378
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MICINN//BFU2010-16563
ASN Neuro
https://doi.org/10.1177/1759091414562107
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sage Publications
publisher.none.fl_str_mv Sage Publications
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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