Utility of Fatty Liver Index to predict reversion to normoglycemia in people with prediabetes

Background: Fatty Liver Index (FLI) is strongly associated with changes in glycemic status and incident Type 2 Diabetes (T2D). The probability of reverting to normoglycemia from a state prediabetes could be determined by FLI, however such relationship remains poorly understood. Aim: To determine the...

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Detalles Bibliográficos
Autores: Busquets-Cortés, Carla, Bennasar-Veny, Miquel, Arturo Lopez-Gonzalez, Angel, Fresneda, Sergio, Abbate, Manuela, Yañez, Aina M
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/23336
Acceso en línea:https://hdl.handle.net/20.500.12105/23336
Access Level:acceso abierto
Palabra clave:Estudios de Cohortes
Ejercicio Físico
Dieta Saludable
Modelos Logísticos
Oportunidad Relativa
Femenino
Masculino
Hígado Graso
Humanos
Persona de Mediana Edad
Glucemia
Adulto Joven
Estilo de Vida
Estado Prediabético
Anciano
Índice de Severidad de la Enfermedad
Adulto
Área Bajo la Curva
Curva ROC
Area Under Curve
Aged
Blood Glucose
Young Adult
Adult
Humans
Life Style
Middle Aged
Fatty Liver
Prediabetic State
Male
Severity of Illness Index
Diet, Healthy
Female
Odds Ratio
Cohort Studies
ROC Curve
Exercise
Logistic Models
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repository_id_str
spelling Utility of Fatty Liver Index to predict reversion to normoglycemia in people with prediabetesBusquets-Cortés, CarlaBennasar-Veny, MiquelArturo Lopez-Gonzalez, AngelFresneda, SergioAbbate, ManuelaYañez, Aina MEstudios de CohortesEjercicio FísicoDieta SaludableModelos LogísticosOportunidad RelativaFemeninoMasculinoHígado GrasoHumanosPersona de Mediana EdadGlucemiaAdulto JovenEstilo de VidaEstado PrediabéticoAncianoÍndice de Severidad de la EnfermedadAdultoÁrea Bajo la CurvaCurva ROCArea Under CurveAgedBlood GlucoseYoung AdultAdultHumansLife StyleMiddle AgedFatty LiverPrediabetic StateMaleSeverity of Illness IndexDiet, HealthyFemaleOdds RatioCohort StudiesROC CurveExerciseLogistic ModelsBackground: Fatty Liver Index (FLI) is strongly associated with changes in glycemic status and incident Type 2 Diabetes (T2D). The probability of reverting to normoglycemia from a state prediabetes could be determined by FLI, however such relationship remains poorly understood. Aim: To determine the clinical interest of using FLI to estimate prediabetes reversion at 5 years in patients with impaired fasting plasma glucose at baseline, and identify those factors associated with changes in FLI, that could contribute to the reversion of prediabetes. Methods: This 5-year cohort study included 16,648 Spanish working adults with prediabetes. Prediabetes was defined as fasting plasma glucose (FPG) between 100 and 125 mg/dl according to the ADA criteria, while prediabetes reversion was defined as a FPG <100 mg/dL. The population was classified as: FLI <30 (no hepatic steatosis), FLI 30-59 (intermediate status), and FLI >= 60 (hepatic steatosis). Results At 5 years follow-up, 33.7% of subjects reverted to normoglycemia (annual rate of 6.7%). The adjusted binomial logistic regression model showed that scoring FLI <30 (OR 1.544; 95% CI 1.355-1.759), performing at least 150 min/week of physical activity (OR 4.600; 95% CI 4.088-5.177) and consuming fruits and vegetables daily (OR 1.682; 95% CI 1.526-1.855) were associated with the probability of reverting form prediabetes to normoglycemia. The ROC curve for prediction of reversion showed that FLI (AUC 0.774;95% CI 0.767-0.781) was a better predictor than FPG (AUC 0.656; 95% CI 0.648-0.664). Conclusions: Regular physical activity, healthy dietary habits and absence of hepatic steatosis are independently associated with the probability of reversion to normoglycemia in adult workers with prediabetes at baseline. Low FLI values (especially FLI< 30) may be useful to predict the probability of prediabetes reversion, especially in active subjects with healthy eating habits, and thus identify those who might benefit from early lifestyle intervention.Public Library of Science (PLOS)20242024-09-1820212021-04-0620212021-04-06research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articlehttps://hdl.handle.net/20.500.12105/23336reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/233362026-06-12T12:43:37Z
dc.title.none.fl_str_mv Utility of Fatty Liver Index to predict reversion to normoglycemia in people with prediabetes
title Utility of Fatty Liver Index to predict reversion to normoglycemia in people with prediabetes
spellingShingle Utility of Fatty Liver Index to predict reversion to normoglycemia in people with prediabetes
Busquets-Cortés, Carla
Estudios de Cohortes
Ejercicio Físico
Dieta Saludable
Modelos Logísticos
Oportunidad Relativa
Femenino
Masculino
Hígado Graso
Humanos
Persona de Mediana Edad
Glucemia
Adulto Joven
Estilo de Vida
Estado Prediabético
Anciano
Índice de Severidad de la Enfermedad
Adulto
Área Bajo la Curva
Curva ROC
Area Under Curve
Aged
Blood Glucose
Young Adult
Adult
Humans
Life Style
Middle Aged
Fatty Liver
Prediabetic State
Male
Severity of Illness Index
Diet, Healthy
Female
Odds Ratio
Cohort Studies
ROC Curve
Exercise
Logistic Models
title_short Utility of Fatty Liver Index to predict reversion to normoglycemia in people with prediabetes
title_full Utility of Fatty Liver Index to predict reversion to normoglycemia in people with prediabetes
title_fullStr Utility of Fatty Liver Index to predict reversion to normoglycemia in people with prediabetes
title_full_unstemmed Utility of Fatty Liver Index to predict reversion to normoglycemia in people with prediabetes
title_sort Utility of Fatty Liver Index to predict reversion to normoglycemia in people with prediabetes
dc.creator.none.fl_str_mv Busquets-Cortés, Carla
Bennasar-Veny, Miquel
Arturo Lopez-Gonzalez, Angel
Fresneda, Sergio
Abbate, Manuela
Yañez, Aina M
author Busquets-Cortés, Carla
author_facet Busquets-Cortés, Carla
Bennasar-Veny, Miquel
Arturo Lopez-Gonzalez, Angel
Fresneda, Sergio
Abbate, Manuela
Yañez, Aina M
author_role author
author2 Bennasar-Veny, Miquel
Arturo Lopez-Gonzalez, Angel
Fresneda, Sergio
Abbate, Manuela
Yañez, Aina M
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Estudios de Cohortes
Ejercicio Físico
Dieta Saludable
Modelos Logísticos
Oportunidad Relativa
Femenino
Masculino
Hígado Graso
Humanos
Persona de Mediana Edad
Glucemia
Adulto Joven
Estilo de Vida
Estado Prediabético
Anciano
Índice de Severidad de la Enfermedad
Adulto
Área Bajo la Curva
Curva ROC
Area Under Curve
Aged
Blood Glucose
Young Adult
Adult
Humans
Life Style
Middle Aged
Fatty Liver
Prediabetic State
Male
Severity of Illness Index
Diet, Healthy
Female
Odds Ratio
Cohort Studies
ROC Curve
Exercise
Logistic Models
topic Estudios de Cohortes
Ejercicio Físico
Dieta Saludable
Modelos Logísticos
Oportunidad Relativa
Femenino
Masculino
Hígado Graso
Humanos
Persona de Mediana Edad
Glucemia
Adulto Joven
Estilo de Vida
Estado Prediabético
Anciano
Índice de Severidad de la Enfermedad
Adulto
Área Bajo la Curva
Curva ROC
Area Under Curve
Aged
Blood Glucose
Young Adult
Adult
Humans
Life Style
Middle Aged
Fatty Liver
Prediabetic State
Male
Severity of Illness Index
Diet, Healthy
Female
Odds Ratio
Cohort Studies
ROC Curve
Exercise
Logistic Models
description Background: Fatty Liver Index (FLI) is strongly associated with changes in glycemic status and incident Type 2 Diabetes (T2D). The probability of reverting to normoglycemia from a state prediabetes could be determined by FLI, however such relationship remains poorly understood. Aim: To determine the clinical interest of using FLI to estimate prediabetes reversion at 5 years in patients with impaired fasting plasma glucose at baseline, and identify those factors associated with changes in FLI, that could contribute to the reversion of prediabetes. Methods: This 5-year cohort study included 16,648 Spanish working adults with prediabetes. Prediabetes was defined as fasting plasma glucose (FPG) between 100 and 125 mg/dl according to the ADA criteria, while prediabetes reversion was defined as a FPG <100 mg/dL. The population was classified as: FLI <30 (no hepatic steatosis), FLI 30-59 (intermediate status), and FLI >= 60 (hepatic steatosis). Results At 5 years follow-up, 33.7% of subjects reverted to normoglycemia (annual rate of 6.7%). The adjusted binomial logistic regression model showed that scoring FLI <30 (OR 1.544; 95% CI 1.355-1.759), performing at least 150 min/week of physical activity (OR 4.600; 95% CI 4.088-5.177) and consuming fruits and vegetables daily (OR 1.682; 95% CI 1.526-1.855) were associated with the probability of reverting form prediabetes to normoglycemia. The ROC curve for prediction of reversion showed that FLI (AUC 0.774;95% CI 0.767-0.781) was a better predictor than FPG (AUC 0.656; 95% CI 0.648-0.664). Conclusions: Regular physical activity, healthy dietary habits and absence of hepatic steatosis are independently associated with the probability of reversion to normoglycemia in adult workers with prediabetes at baseline. Low FLI values (especially FLI< 30) may be useful to predict the probability of prediabetes reversion, especially in active subjects with healthy eating habits, and thus identify those who might benefit from early lifestyle intervention.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-04-06
2021
2021-04-06
2024
2024-09-18
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.12105/23336
url https://hdl.handle.net/20.500.12105/23336
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science (PLOS)
publisher.none.fl_str_mv Public Library of Science (PLOS)
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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