Monoamine oxidase A (MAOA) interaction with parenting practices on Callous- Unemotional Traits in Preschoolers

Background and Objectives: From a gene-by-environment perspective, parenting in interaction with the polymorphism in the Monoamine oxidase A (MAOA) gene (MAOA-uVNTR) might also be associated with increased callous-unemotional traits (CU) in preschoolers. MAOA-uVNTR results in differential enzyme act...

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Detalles Bibliográficos
Autores: Pueyo, Natalia|||0000-0003-3251-7859, Navarro, José-Blas|||0000-0001-5929-4224, Fatjó-Vilas, Mar|||0000-0001-9963-6241, Osa, Nuria de la|||0000-0003-4499-0942, Penelo Werner, Eva|||0000-0001-6796-7660, Fañanás Saura, Lourdes, Ezpeleta, Lourdes|||0000-0002-8957-083X
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:249591
Acceso en línea:https://ddd.uab.cat/record/249591
https://dx.doi.org/urn:doi:10.1016/j.ejpsy.2021.02.003
Access Level:acceso abierto
Palabra clave:Callous unemotional traits
Development
Gene by environment
MAOA
Parenting practices
Preschool
Descripción
Sumario:Background and Objectives: From a gene-by-environment perspective, parenting in interaction with the polymorphism in the Monoamine oxidase A (MAOA) gene (MAOA-uVNTR) might also be associated with increased callous-unemotional traits (CU) in preschoolers. MAOA-uVNTR results in differential enzyme activity, so that high-activity alleles (MAOA-H) are linked to reduced dopamine, serotonin, and norepinephrine availability in comparison to low-activity allele (MAOA-L). As MAOA-uVNTR has been previously described to moderate the relationship between childhood parental maltreatment and aggressive and antisocial behavior, it may also play a role in CU traits etiology.

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