Restoring oscillatory dynamics in Alzheimer's disease: a laminar whole-brain model of serotonergic psychedelic effects

Data de publicació electrònica: 12-02-2026

Detalles Bibliográficos
Autores: Gendra, Jan C., Lopez-Sola, Edmundo, Castaldo, Francesca, Lleal-Custey, Èlia, Sanchez Todo, Roser, Vohryzek, Jakub, Salvador, Ricardo, Andrzejak, Ralph Gregor, Ruffini, Giulio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2026
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:dnet:recercat____::6d8c60640e93e333cd5360e540063de3
Acceso en línea:https://hdl.handle.net/10230/73088
http://dx.doi.org/https://doi.org/10.1162/NETN.a.540
Access Level:acceso abierto
Palabra clave:Psychedelics
Alzheimer&apos
s disease
Neuropsychiatry
Serotonin
5-HT2A
PET
Whole-brain model
Laminar neural mass model
fMRI
EEG
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dc.title.none.fl_str_mv Restoring oscillatory dynamics in Alzheimer's disease: a laminar whole-brain model of serotonergic psychedelic effects
title Restoring oscillatory dynamics in Alzheimer's disease: a laminar whole-brain model of serotonergic psychedelic effects
spellingShingle Restoring oscillatory dynamics in Alzheimer's disease: a laminar whole-brain model of serotonergic psychedelic effects
Gendra, Jan C.
Psychedelics
Alzheimer&apos
s disease
Neuropsychiatry
Serotonin
5-HT2A
PET
Whole-brain model
Laminar neural mass model
fMRI
EEG
title_short Restoring oscillatory dynamics in Alzheimer's disease: a laminar whole-brain model of serotonergic psychedelic effects
title_full Restoring oscillatory dynamics in Alzheimer's disease: a laminar whole-brain model of serotonergic psychedelic effects
title_fullStr Restoring oscillatory dynamics in Alzheimer's disease: a laminar whole-brain model of serotonergic psychedelic effects
title_full_unstemmed Restoring oscillatory dynamics in Alzheimer's disease: a laminar whole-brain model of serotonergic psychedelic effects
title_sort Restoring oscillatory dynamics in Alzheimer's disease: a laminar whole-brain model of serotonergic psychedelic effects
dc.creator.none.fl_str_mv Gendra, Jan C.
Lopez-Sola, Edmundo
Castaldo, Francesca
Lleal-Custey, Èlia
Sanchez Todo, Roser
Vohryzek, Jakub
Salvador, Ricardo
Andrzejak, Ralph Gregor
Ruffini, Giulio
author Gendra, Jan C.
author_facet Gendra, Jan C.
Lopez-Sola, Edmundo
Castaldo, Francesca
Lleal-Custey, Èlia
Sanchez Todo, Roser
Vohryzek, Jakub
Salvador, Ricardo
Andrzejak, Ralph Gregor
Ruffini, Giulio
author_role author
author2 Lopez-Sola, Edmundo
Castaldo, Francesca
Lleal-Custey, Èlia
Sanchez Todo, Roser
Vohryzek, Jakub
Salvador, Ricardo
Andrzejak, Ralph Gregor
Ruffini, Giulio
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Psychedelics
Alzheimer&apos
s disease
Neuropsychiatry
Serotonin
5-HT2A
PET
Whole-brain model
Laminar neural mass model
fMRI
EEG
topic Psychedelics
Alzheimer&apos
s disease
Neuropsychiatry
Serotonin
5-HT2A
PET
Whole-brain model
Laminar neural mass model
fMRI
EEG
description Data de publicació electrònica: 12-02-2026
publishDate 2026
dc.date.none.fl_str_mv 2026
2026
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/10230/73088
http://dx.doi.org/https://doi.org/10.1162/NETN.a.540
https://hdl.handle.net/10230/73088
url https://hdl.handle.net/10230/73088
http://dx.doi.org/https://doi.org/10.1162/NETN.a.540
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Network Neuroscience. 2026 Feb 12
info:eu-repo/grantAgreement/EC/H2020/855109
info:eu-repo/grantAgreement/EC/H2020/101017716
info:eu-repo/grantAgreement/ES/2PE/PID2020-118196GB-I00
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/legalcode
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/legalcode
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MIT Press
publisher.none.fl_str_mv MIT Press
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
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spelling Restoring oscillatory dynamics in Alzheimer's disease: a laminar whole-brain model of serotonergic psychedelic effectsGendra, Jan C.Lopez-Sola, EdmundoCastaldo, FrancescaLleal-Custey, ÈliaSanchez Todo, RoserVohryzek, JakubSalvador, RicardoAndrzejak, Ralph GregorRuffini, GiulioPsychedelicsAlzheimer&aposs diseaseNeuropsychiatrySerotonin5-HT2APETWhole-brain modelLaminar neural mass modelfMRIEEGData de publicació electrònica: 12-02-2026Classical serotonergic psychedelics show promise in addressing neurodegenerative disorders such as Alzheimer's disease by modulating pathological brain dynamics. However, the precise neurobiological mechanisms underlying their effects remain elusive. This study introduces a personalized whole-brain model built upon a laminar neural mass framework to elucidate these effects. Using multimodal neuroimaging data from 30 subjects diagnosed with mild to moderate Alzheimer's disease, we simulate the impact of serotonin 2A receptor activation, characteristic of psychedelics, on cortical dynamics. By modulating the excitability of layer 5 pyramidal neurons, our models reproduce hallmark changes in EEG power spectra observed under psychedelics, including alpha power suppression and gamma power enhancement. These spectral shifts are shown to correlate strongly with the regional distribution of serotonin 2A receptors. Furthermore, simulated EEG reveals increased complexity and entropy, suggesting restored network function. These findings underscore the potential of serotonergic psychedelics to reestablish healthy oscillatory dynamics in the prodromal and early phases of Alzheimer's disease and offer mechanistic insights into their potential therapeutic effects in neurodegenerative disorders.Edmundo Lopez-Sola, H2020 European Research Council (https://dx.doi.org/10.13039 /100010663), Award ID: 855109. Francesca Castaldo, H2020 European Research Council (https://dx.doi.org/10.13039/100010663), Award ID: 855109. Èlia Lleal-Custey, H2020 European Research Council (https://dx.doi.org/10.13039/100010663), Award ID: 855109. Roser Sanchez-Todo, H2020 European Research Council (https://dx.doi.org/10.13039/100010663), Award ID: 855109. Ricardo Salvador, H2020 European Research Council (https://dx.doi.org/10.13039/100010663), Award ID: 855109. Giulio Ruffini, H2020 European Research Council (https://dx.doi.org/10.13039/100010663), Award ID: 855109. Edmundo Lopez-Sola, H2020 Future and Emerging Technologies (https://dx.doi.org/10.13039 /100010664), Award ID: 101017716. Francesca Castaldo, H2020 Future and Emerging Technologies (https://dx.doi.org/10.13039/100010664), Award ID: 101017716. Èlia Lleal-Custey, H2020 Future and Emerging Technologies (https://dx.doi.org/10.13039/100010664), Award ID: 101017716. Roser Sanchez-Todo, H2020 Future and Emerging Technologies (https://dx.doi.org/10.13039/100010664), Award ID: 101017716. Jakub Vohryzek, H2020 Future and Emerging Technologies (https://dx.doi.org/10.13039/100010664), Award ID: 101017716. Ricardo Salvador, H2020 Future and Emerging Technologies (https://dx.doi.org/10.13039/100010664), Award ID: 101017716. Giulio Ruffini, H2020 Future and Emerging Technologies (https://dx.doi.org/10.13039/100010664), Award ID: 101017716. Ralph G. Andrzejak, Agencia Estatal de Investigación (https://dx.doi.org/10.13039/501100011033), Award ID: PID2020118196GBI00/MICIU/AEI/10.13039/501100011033. Jan C. Gendra, Elitenetzwerk Bayern (https://dx.doi.org/10.13039/501100008848).MIT Press2026202620262026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/10230/73088http://dx.doi.org/https://doi.org/10.1162/NETN.a.540https://hdl.handle.net/10230/73088reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésNetwork Neuroscience. 2026 Feb 12info:eu-repo/grantAgreement/EC/H2020/855109info:eu-repo/grantAgreement/EC/H2020/101017716info:eu-repo/grantAgreement/ES/2PE/PID2020-118196GB-I00© 2025 Massachusetts Institute of Technology Published under a Creative Commons Attribution 4.0 International (CC BY 4.0) license. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. For a full description of the license, please visit https://creativecommons.org/licenses/by/4.0/legalcode.https://creativecommons.org/licenses/by/4.0/legalcodeinfo:eu-repo/semantics/openAccessoai:dnet:recercat____::6d8c60640e93e333cd5360e540063de32026-05-29T05:05:01Z
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