Dynamic positioning of the fission yeast cell division plane

A key question in cytokinesis is how the cell division plane is positioned. Whereas microtubules of the mitotic apparatus specify the division site in animal cells, we show here that the nucleus plays this role in the fission yeast Schizosaccharomyces pombe. By centrifuging cells to move the nucleus...

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Detalles Bibliográficos
Autores: Daga, Rafael R., Chang, Fred
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2005
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/198695
Acceso en línea:http://hdl.handle.net/10261/198695
Access Level:acceso abierto
Palabra clave:Cytokinesis
Nucleus
Schizosaccharomyces pombe
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spelling Dynamic positioning of the fission yeast cell division planeDaga, Rafael R.Chang, FredCytokinesisNucleusSchizosaccharomyces pombeA key question in cytokinesis is how the cell division plane is positioned. Whereas microtubules of the mitotic apparatus specify the division site in animal cells, we show here that the nucleus plays this role in the fission yeast Schizosaccharomyces pombe. By centrifuging cells to move the nucleus, we find that the nucleus (or a nuclear-associated structure) actively influences the position of contractile ring assembly during early mitosis. Displacement of the nucleus during this induction period can lead to formation of multiple rings. The nucleus signals its position in a microtubule-independent manner by emitting the protein mid1p. Furthermore, movement of ring fragments together minimizes formation of multiple division sites. These dynamic mechanisms of ring positioning provide a robust coordination of nuclear and cell division.National Academy of Sciences (U.S.)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2020202020052020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/198695reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.1073/pnas.0409021102Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1986952026-05-22T06:33:51Z
dc.title.none.fl_str_mv Dynamic positioning of the fission yeast cell division plane
title Dynamic positioning of the fission yeast cell division plane
spellingShingle Dynamic positioning of the fission yeast cell division plane
Daga, Rafael R.
Cytokinesis
Nucleus
Schizosaccharomyces pombe
title_short Dynamic positioning of the fission yeast cell division plane
title_full Dynamic positioning of the fission yeast cell division plane
title_fullStr Dynamic positioning of the fission yeast cell division plane
title_full_unstemmed Dynamic positioning of the fission yeast cell division plane
title_sort Dynamic positioning of the fission yeast cell division plane
dc.creator.none.fl_str_mv Daga, Rafael R.
Chang, Fred
author Daga, Rafael R.
author_facet Daga, Rafael R.
Chang, Fred
author_role author
author2 Chang, Fred
author2_role author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Cytokinesis
Nucleus
Schizosaccharomyces pombe
topic Cytokinesis
Nucleus
Schizosaccharomyces pombe
description A key question in cytokinesis is how the cell division plane is positioned. Whereas microtubules of the mitotic apparatus specify the division site in animal cells, we show here that the nucleus plays this role in the fission yeast Schizosaccharomyces pombe. By centrifuging cells to move the nucleus, we find that the nucleus (or a nuclear-associated structure) actively influences the position of contractile ring assembly during early mitosis. Displacement of the nucleus during this induction period can lead to formation of multiple rings. The nucleus signals its position in a microtubule-independent manner by emitting the protein mid1p. Furthermore, movement of ring fragments together minimizes formation of multiple division sites. These dynamic mechanisms of ring positioning provide a robust coordination of nuclear and cell division.
publishDate 2005
dc.date.none.fl_str_mv 2005
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/198695
url http://hdl.handle.net/10261/198695
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1073/pnas.0409021102
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv National Academy of Sciences (U.S.)
publisher.none.fl_str_mv National Academy of Sciences (U.S.)
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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