Feed efficiency and the liver proteome of fattening lambs are modified by feed restriction during the suckling period

9 páginas, 4 tablas, 2 figuras.

Detalles Bibliográficos
Autores: Santos Baza, Alba, Valdés, Carmen, Giráldez, Francisco Javier, López, Secundino, France, J., Frutos, Javier, Fernández Gutiérrez, Miguel, Andrés, Sonia
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/168006
Acceso en línea:http://hdl.handle.net/10261/168006
Access Level:acceso abierto
Palabra clave:Feed restriction
Feed efficiency
Metabolic programming
Lamb
Liver proteome
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spelling Feed efficiency and the liver proteome of fattening lambs are modified by feed restriction during the suckling periodSantos Baza, AlbaValdés, CarmenGiráldez, Francisco JavierLópez, SecundinoFrance, J.Frutos, JavierFernández Gutiérrez, MiguelAndrés, SoniaFeed restrictionFeed efficiencyMetabolic programmingLambLiver proteome9 páginas, 4 tablas, 2 figuras.The present study was designed to describe the effects of early feed restriction of Merino lambs on feed efficiency during the fattening period by examining ruminal microbiota and fermentation parameters, gastrointestinal morphology, digestibility or liver proteome. In total, 24 male Merino lambs were randomly assigned to two experimental treatments (n=12 per treatment). Lambs of the first group (ad libitum (ADL)) were kept permanently with the dams, whereas the other 12 lambs (restricted (RES)) were milk restricted. When lambs reached a live BW (LBW) of 15 kg, all the animals were offered the same complete pelleted diet (35 g dry matter/kg LBW per day) until slaughter at a LBW of 27 kg. The RES lambs showed poorer feed efficiency during the fattening period when compared with the ADL group (feed to gain ratio, 3.69 v. 3.05, P<0.001). No differences were observed in ruminal microbiota, fermentation parameters or apparent digestibility. However, the proportion of the small intestine and the length of ileal villi were reduced in the RES lambs. In total, 26 spots/proteins were identified in the liver proteomic profile, with significant differences (P<0.05) between experimental treatments, suggesting a higher catabolism of proteins and a reduction in beta-oxidation of fatty acids in RES lambs when compared with the ADL animals. In conclusion, early feed restriction of Merino lambs during the suckling period promotes long-term effects on the small intestine and the proteomic profile of the liver, which may influence the metabolic use of nutrients, thus negatively affecting feed efficiency during the fattening phase.This work was funded by the Spanish Ministry of Economy, Industry and Competitiveness (MINECO, AGL2014-54124R). Alba Santos gratefully acknowledges receipt of a pre-doctoral grant from the Spanish Ministry of Education, Culture and Sport (MECD, FPU15/01630). The authors also thank Julio Benavides for providing histological sections of intestinal samples.Peer reviewedCambridge University PressMinisterio de Economía y Competitividad (España)Ministerio de Educación, Cultura y Deporte (España)Giráldez, Francisco Javier [0000-0002-0680-1541]López, Secundino [0000-0001-6267-683X]Andrés, Sonia [0000-0001-5255-1582]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201820182018info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/168006reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2014-54124-Rhttp://dx.doi.org/10.1017/S1751731118000046Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1680062026-05-22T06:33:51Z
dc.title.none.fl_str_mv Feed efficiency and the liver proteome of fattening lambs are modified by feed restriction during the suckling period
title Feed efficiency and the liver proteome of fattening lambs are modified by feed restriction during the suckling period
spellingShingle Feed efficiency and the liver proteome of fattening lambs are modified by feed restriction during the suckling period
Santos Baza, Alba
Feed restriction
Feed efficiency
Metabolic programming
Lamb
Liver proteome
title_short Feed efficiency and the liver proteome of fattening lambs are modified by feed restriction during the suckling period
title_full Feed efficiency and the liver proteome of fattening lambs are modified by feed restriction during the suckling period
title_fullStr Feed efficiency and the liver proteome of fattening lambs are modified by feed restriction during the suckling period
title_full_unstemmed Feed efficiency and the liver proteome of fattening lambs are modified by feed restriction during the suckling period
title_sort Feed efficiency and the liver proteome of fattening lambs are modified by feed restriction during the suckling period
dc.creator.none.fl_str_mv Santos Baza, Alba
Valdés, Carmen
Giráldez, Francisco Javier
López, Secundino
France, J.
Frutos, Javier
Fernández Gutiérrez, Miguel
Andrés, Sonia
author Santos Baza, Alba
author_facet Santos Baza, Alba
Valdés, Carmen
Giráldez, Francisco Javier
López, Secundino
France, J.
Frutos, Javier
Fernández Gutiérrez, Miguel
Andrés, Sonia
author_role author
author2 Valdés, Carmen
Giráldez, Francisco Javier
López, Secundino
France, J.
Frutos, Javier
Fernández Gutiérrez, Miguel
Andrés, Sonia
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Ministerio de Educación, Cultura y Deporte (España)
Giráldez, Francisco Javier [0000-0002-0680-1541]
López, Secundino [0000-0001-6267-683X]
Andrés, Sonia [0000-0001-5255-1582]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Feed restriction
Feed efficiency
Metabolic programming
Lamb
Liver proteome
topic Feed restriction
Feed efficiency
Metabolic programming
Lamb
Liver proteome
description 9 páginas, 4 tablas, 2 figuras.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/168006
url http://hdl.handle.net/10261/168006
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2014-54124-R
http://dx.doi.org/10.1017/S1751731118000046
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Cambridge University Press
publisher.none.fl_str_mv Cambridge University Press
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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