Follicular helper T-cell lymphomas: disease spectrum, relationship with clonal hematopoiesis, and mimics. A report of the 2022 EA4HP/SH lymphoma workshop

Follicular helper T-cell lymphomas (TFH lymphomas) were discussed in session V of the lymphoma workshop of the European Association for Haematopathology (EA4HP)/Society for Hematopathology (SH) 2022 meeting in Florence, Italy. The session focused on the morphologic spectrum of TFH lymphoma, includin...

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Autores: Ondrejka, Sarah L., Amador, Catalina, Climent, Fina, Ng, Siok-Bian, Soma, Lorinda, Zamo, Alberto, Dirnhofer, Stefan, Quintanilla Martinez, Leticia, Wotherspoon, Andrew, Leoncini, Lorenzo, Leval, Laurence de
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/224646
Acesso em linha:https://hdl.handle.net/2445/224646
Access Level:acceso abierto
Palavra-chave:Diagnòstic immunohistoquímic
Malalties hematològiques
Classificació de tumors
Diagnostic immunohistochemistry
Hematologic diseases
Tumors classification
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spelling Follicular helper T-cell lymphomas: disease spectrum, relationship with clonal hematopoiesis, and mimics. A report of the 2022 EA4HP/SH lymphoma workshopOndrejka, Sarah L.Amador, CatalinaCliment, FinaNg, Siok-BianSoma, LorindaZamo, AlbertoDirnhofer, StefanQuintanilla Martinez, LeticiaWotherspoon, AndrewLeoncini, LorenzoLeval, Laurence deDiagnòstic immunohistoquímicMalalties hematològiquesClassificació de tumorsDiagnostic immunohistochemistryHematologic diseasesTumors classificationFollicular helper T-cell lymphomas (TFH lymphomas) were discussed in session V of the lymphoma workshop of the European Association for Haematopathology (EA4HP)/Society for Hematopathology (SH) 2022 meeting in Florence, Italy. The session focused on the morphologic spectrum of TFH lymphoma, including its three subtypes: angioimmunoblastic-type (AITL), follicular-type, and not otherwise specified (NOS). The submitted cases encompassed classic examples of TFH lymphoma and unusual cases such as those with early or indolent presentations, associated B-cell proliferations, or Hodgkin/Reed-Sternberg-like cells. The relationship between TFH lymphoma and clonal hematopoiesis was highlighted by several cases documenting divergent evolution of myeloid neoplasm and AITL from shared clonal mutations. The distinction between TFH lymphoma and peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS), was stressed, and many challenging examples were presented. Various cases highlighted the difficulties of differentiating TFH lymphoma from other established types of lymphoma and reactive conditions. Cutaneous T-cell lymphoma expressing TFH markers, particularly when resulting in lymph node involvement, should be distinguished from TFH lymphomas. Additional immunophenotyping and next-generation sequencing studies were performed on various cases in this session, highlighting the importance of these technologies to our current understanding and classification of TFH lymphomas.Springer Science and Business Media LLC2025202520232025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion17 p.application/pdfhttps://hdl.handle.net/2445/224646Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1007/s00428-023-03607-5Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin, 2023, vol. 483, 349-365https://doi.org/10.1007/s00428-023-03607-5cc-by (c) Ondrejka, Sarah L. et al., 2023https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2246462026-05-29T05:05:01Z
dc.title.none.fl_str_mv Follicular helper T-cell lymphomas: disease spectrum, relationship with clonal hematopoiesis, and mimics. A report of the 2022 EA4HP/SH lymphoma workshop
title Follicular helper T-cell lymphomas: disease spectrum, relationship with clonal hematopoiesis, and mimics. A report of the 2022 EA4HP/SH lymphoma workshop
spellingShingle Follicular helper T-cell lymphomas: disease spectrum, relationship with clonal hematopoiesis, and mimics. A report of the 2022 EA4HP/SH lymphoma workshop
Ondrejka, Sarah L.
Diagnòstic immunohistoquímic
Malalties hematològiques
Classificació de tumors
Diagnostic immunohistochemistry
Hematologic diseases
Tumors classification
title_short Follicular helper T-cell lymphomas: disease spectrum, relationship with clonal hematopoiesis, and mimics. A report of the 2022 EA4HP/SH lymphoma workshop
title_full Follicular helper T-cell lymphomas: disease spectrum, relationship with clonal hematopoiesis, and mimics. A report of the 2022 EA4HP/SH lymphoma workshop
title_fullStr Follicular helper T-cell lymphomas: disease spectrum, relationship with clonal hematopoiesis, and mimics. A report of the 2022 EA4HP/SH lymphoma workshop
title_full_unstemmed Follicular helper T-cell lymphomas: disease spectrum, relationship with clonal hematopoiesis, and mimics. A report of the 2022 EA4HP/SH lymphoma workshop
title_sort Follicular helper T-cell lymphomas: disease spectrum, relationship with clonal hematopoiesis, and mimics. A report of the 2022 EA4HP/SH lymphoma workshop
dc.creator.none.fl_str_mv Ondrejka, Sarah L.
Amador, Catalina
Climent, Fina
Ng, Siok-Bian
Soma, Lorinda
Zamo, Alberto
Dirnhofer, Stefan
Quintanilla Martinez, Leticia
Wotherspoon, Andrew
Leoncini, Lorenzo
Leval, Laurence de
author Ondrejka, Sarah L.
author_facet Ondrejka, Sarah L.
Amador, Catalina
Climent, Fina
Ng, Siok-Bian
Soma, Lorinda
Zamo, Alberto
Dirnhofer, Stefan
Quintanilla Martinez, Leticia
Wotherspoon, Andrew
Leoncini, Lorenzo
Leval, Laurence de
author_role author
author2 Amador, Catalina
Climent, Fina
Ng, Siok-Bian
Soma, Lorinda
Zamo, Alberto
Dirnhofer, Stefan
Quintanilla Martinez, Leticia
Wotherspoon, Andrew
Leoncini, Lorenzo
Leval, Laurence de
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Diagnòstic immunohistoquímic
Malalties hematològiques
Classificació de tumors
Diagnostic immunohistochemistry
Hematologic diseases
Tumors classification
topic Diagnòstic immunohistoquímic
Malalties hematològiques
Classificació de tumors
Diagnostic immunohistochemistry
Hematologic diseases
Tumors classification
description Follicular helper T-cell lymphomas (TFH lymphomas) were discussed in session V of the lymphoma workshop of the European Association for Haematopathology (EA4HP)/Society for Hematopathology (SH) 2022 meeting in Florence, Italy. The session focused on the morphologic spectrum of TFH lymphoma, including its three subtypes: angioimmunoblastic-type (AITL), follicular-type, and not otherwise specified (NOS). The submitted cases encompassed classic examples of TFH lymphoma and unusual cases such as those with early or indolent presentations, associated B-cell proliferations, or Hodgkin/Reed-Sternberg-like cells. The relationship between TFH lymphoma and clonal hematopoiesis was highlighted by several cases documenting divergent evolution of myeloid neoplasm and AITL from shared clonal mutations. The distinction between TFH lymphoma and peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS), was stressed, and many challenging examples were presented. Various cases highlighted the difficulties of differentiating TFH lymphoma from other established types of lymphoma and reactive conditions. Cutaneous T-cell lymphoma expressing TFH markers, particularly when resulting in lymph node involvement, should be distinguished from TFH lymphomas. Additional immunophenotyping and next-generation sequencing studies were performed on various cases in this session, highlighting the importance of these technologies to our current understanding and classification of TFH lymphomas.
publishDate 2023
dc.date.none.fl_str_mv 2023
2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/224646
url https://hdl.handle.net/2445/224646
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1007/s00428-023-03607-5
Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin, 2023, vol. 483, 349-365
https://doi.org/10.1007/s00428-023-03607-5
dc.rights.none.fl_str_mv cc-by (c) Ondrejka, Sarah L. et al., 2023
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Ondrejka, Sarah L. et al., 2023
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 17 p.
application/pdf
dc.publisher.none.fl_str_mv Springer Science and Business Media LLC
publisher.none.fl_str_mv Springer Science and Business Media LLC
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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