Systematic review of cognitive sequelae of non-central nervous system cancer and cancer therapy

Purpose The aim of this review is to provide an updated overview of chemotherapy-related cognitive impairment (CRCI) in patients with cancer outside central nervous system (CNS), its incidence and prevalence, the cognitive pattern in neuropsychological studies, neuroimaging findings, and the relatio...

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Autores: Cerulla Torrente, Noemí|||0000-0002-2066-3536, Navarro, José-Blas|||0000-0001-5929-4224, Osa, Nuria de la|||0000-0003-4499-0942
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:322351
Acceso en línea:https://ddd.uab.cat/record/322351
https://dx.doi.org/urn:doi:10.1007/s11764-020-00870-2
Access Level:acceso abierto
Palabra clave:Cancer
Chemobrain
Chemotherapy
Cognitive impairment
Neuropsychology
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spelling Systematic review of cognitive sequelae of non-central nervous system cancer and cancer therapyCerulla Torrente, Noemí|||0000-0002-2066-3536Navarro, José-Blas|||0000-0001-5929-4224Osa, Nuria de la|||0000-0003-4499-0942CancerChemobrainChemotherapyCognitive impairmentNeuropsychologyPurpose The aim of this review is to provide an updated overview of chemotherapy-related cognitive impairment (CRCI) in patients with cancer outside central nervous system (CNS), its incidence and prevalence, the cognitive pattern in neuropsychological studies, neuroimaging findings, and the relationship between chemobrain and aging. Methodological limitations of studies are also discussed. Methods This review was guided by the PRISMA statement. The MEDLINE and Scopus databases were employed to search articles about CRCI in non-CNS cancer patients published from January 2004 to September 2019. Two types of research were reviewed: prospective studies addressing the effects of chemotherapy on cognition and systematic reviews about factors related with CRCI, also as neuroimaging findings and current available treatments. Results Fifty-nine studies meeting the criteria were analyzed: 47 were longitudinal studies on cancer and cognition and 12 were reviews on risk factors, neuroimaging, and treatment. The majority of studies find cognitive impairment in patients with cancer treated with chemotherapy. The body of the literature on breast cancer is the most abundant, but there are also studies on colorectal, testicular, and lung cancer. Neuroimaging studies show changes in structure and activation in patients undergoing chemotherapy. Non-pharmacological treatment is effective for improving cognition and quality of life. Conclusions The occurrence of CRCI during the course of treatment in people with different types of cancer is frequent. Some risk factors have been identified, but CRCI is a complex phenomenon, with mediating factors related to cancer and treatment and moderating factors related with lifestyle and health. Implications for Cancer Survivors This review highlights the importance of recognizing that this cognitive dysfunction is fre- quent, mild to moderate in nature but with great impact on quality of life. 22020-01-0120202020-01-01Article de revisióhttp://purl.org/coar/resource_type/c_dcae04bcAMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/322351https://dx.doi.org/urn:doi:10.1007/s11764-020-00870-2reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest material està protegit per drets d'autor i/o drets afins. Podeu utilitzar aquest material en funció del que permet la legislació de drets d'autor i drets afins d'aplicació al vostre cas. Per a d'altres usos heu d'obtenir permís del(s) titular(s) de drets.https://rightsstatements.org/vocab/InC/1.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3223512026-06-06T12:50:31Z
dc.title.none.fl_str_mv Systematic review of cognitive sequelae of non-central nervous system cancer and cancer therapy
title Systematic review of cognitive sequelae of non-central nervous system cancer and cancer therapy
spellingShingle Systematic review of cognitive sequelae of non-central nervous system cancer and cancer therapy
Cerulla Torrente, Noemí|||0000-0002-2066-3536
Cancer
Chemobrain
Chemotherapy
Cognitive impairment
Neuropsychology
title_short Systematic review of cognitive sequelae of non-central nervous system cancer and cancer therapy
title_full Systematic review of cognitive sequelae of non-central nervous system cancer and cancer therapy
title_fullStr Systematic review of cognitive sequelae of non-central nervous system cancer and cancer therapy
title_full_unstemmed Systematic review of cognitive sequelae of non-central nervous system cancer and cancer therapy
title_sort Systematic review of cognitive sequelae of non-central nervous system cancer and cancer therapy
dc.creator.none.fl_str_mv Cerulla Torrente, Noemí|||0000-0002-2066-3536
Navarro, José-Blas|||0000-0001-5929-4224
Osa, Nuria de la|||0000-0003-4499-0942
author Cerulla Torrente, Noemí|||0000-0002-2066-3536
author_facet Cerulla Torrente, Noemí|||0000-0002-2066-3536
Navarro, José-Blas|||0000-0001-5929-4224
Osa, Nuria de la|||0000-0003-4499-0942
author_role author
author2 Navarro, José-Blas|||0000-0001-5929-4224
Osa, Nuria de la|||0000-0003-4499-0942
author2_role author
author
dc.subject.none.fl_str_mv Cancer
Chemobrain
Chemotherapy
Cognitive impairment
Neuropsychology
topic Cancer
Chemobrain
Chemotherapy
Cognitive impairment
Neuropsychology
description Purpose The aim of this review is to provide an updated overview of chemotherapy-related cognitive impairment (CRCI) in patients with cancer outside central nervous system (CNS), its incidence and prevalence, the cognitive pattern in neuropsychological studies, neuroimaging findings, and the relationship between chemobrain and aging. Methodological limitations of studies are also discussed. Methods This review was guided by the PRISMA statement. The MEDLINE and Scopus databases were employed to search articles about CRCI in non-CNS cancer patients published from January 2004 to September 2019. Two types of research were reviewed: prospective studies addressing the effects of chemotherapy on cognition and systematic reviews about factors related with CRCI, also as neuroimaging findings and current available treatments. Results Fifty-nine studies meeting the criteria were analyzed: 47 were longitudinal studies on cancer and cognition and 12 were reviews on risk factors, neuroimaging, and treatment. The majority of studies find cognitive impairment in patients with cancer treated with chemotherapy. The body of the literature on breast cancer is the most abundant, but there are also studies on colorectal, testicular, and lung cancer. Neuroimaging studies show changes in structure and activation in patients undergoing chemotherapy. Non-pharmacological treatment is effective for improving cognition and quality of life. Conclusions The occurrence of CRCI during the course of treatment in people with different types of cancer is frequent. Some risk factors have been identified, but CRCI is a complex phenomenon, with mediating factors related to cancer and treatment and moderating factors related with lifestyle and health. Implications for Cancer Survivors This review highlights the importance of recognizing that this cognitive dysfunction is fre- quent, mild to moderate in nature but with great impact on quality of life.
publishDate 2020
dc.date.none.fl_str_mv 2
2020-01-01
2020
2020-01-01
dc.type.none.fl_str_mv Article de revisió
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url https://ddd.uab.cat/record/322351
https://dx.doi.org/urn:doi:10.1007/s11764-020-00870-2
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
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dc.rights.none.fl_str_mv open access
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instname:Universitat Autònoma de Barcelona
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