New Treatment Strategies for Alcohol-Induced Heart Damage.

High-dose alcohol misuse induces multiple noxious cardiac effects, including myocyte hypertrophy and necrosis, interstitial fibrosis, decreased ventricular contraction and ventricle enlargement. These effects produce diastolic and systolic ventricular dysfunction leading to congestive heart failure,...

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Detalhes bibliográficos
Autores: Fernández-Solà, J. (Joaquim), Planavila Porta, Ana
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/110200
Acesso em linha:https://hdl.handle.net/2445/110200
Access Level:acceso abierto
Palavra-chave:Malalties cardiovasculars
Apoptosi
Hipertròfia
Alcoholisme
Cardiovascular diseases
Apoptosis
Hypertrophy
Alcoholism
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spelling New Treatment Strategies for Alcohol-Induced Heart Damage.Fernández-Solà, J. (Joaquim)Planavila Porta, AnaMalalties cardiovascularsApoptosiHipertròfiaAlcoholismeCardiovascular diseasesApoptosisHypertrophyAlcoholismHigh-dose alcohol misuse induces multiple noxious cardiac effects, including myocyte hypertrophy and necrosis, interstitial fibrosis, decreased ventricular contraction and ventricle enlargement. These effects produce diastolic and systolic ventricular dysfunction leading to congestive heart failure, arrhythmias and an increased death rate. There are multiple, dose-dependent, synchronic and synergistic mechanisms of alcohol-induced cardiac damage. Ethanol alters membrane permeability and composition, interferes with receptors and intracellular transients, induces oxidative, metabolic and energy damage, decreases protein synthesis, excitation-contraction coupling and increases cell apoptosis. In addition, ethanol decreases myocyte protective and repair mechanisms and their regeneration. Although there are diverse different strategies to directly target alcohol-induced heart damage, they are partially effective, and can only be used as support medication in a multidisciplinary approach. Alcohol abstinence is the preferred goal, but control drinking is useful in alcohol-addicted subjects not able to abstain. Correction of nutrition, ionic and vitamin deficiencies and control of alcohol-related systemic organ damage are compulsory. Recently, several growth factors (myostatin, IGF-1, leptin, ghrelin, miRNA, and ROCK inhibitors) and new cardiomyokines such as FGF21 have been described to regulate cardiac plasticity and decrease cardiac damage, improving cardiac repair mechanisms, and they are promising agents in this field. New potential therapeutic targets aim to control oxidative damage, myocyte hypertrophy, interstitial fibrosis and persistent apoptosis In addition, stem-cell therapy may improve myocyte regeneration. However, these strategies are not yet approved for clinical use.MDPI2017201720162017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion22 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/110200Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/ijms17101651International Journal of Molecular Sciences, 2016, vol. 17, num. 10 , p. E1651-1661https://doi.org/10.3390/ijms17101651cc-by (c) Fernández-Solà, J. (Joaquim) et al., 2016http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1102002026-05-29T05:05:01Z
dc.title.none.fl_str_mv New Treatment Strategies for Alcohol-Induced Heart Damage.
title New Treatment Strategies for Alcohol-Induced Heart Damage.
spellingShingle New Treatment Strategies for Alcohol-Induced Heart Damage.
Fernández-Solà, J. (Joaquim)
Malalties cardiovasculars
Apoptosi
Hipertròfia
Alcoholisme
Cardiovascular diseases
Apoptosis
Hypertrophy
Alcoholism
title_short New Treatment Strategies for Alcohol-Induced Heart Damage.
title_full New Treatment Strategies for Alcohol-Induced Heart Damage.
title_fullStr New Treatment Strategies for Alcohol-Induced Heart Damage.
title_full_unstemmed New Treatment Strategies for Alcohol-Induced Heart Damage.
title_sort New Treatment Strategies for Alcohol-Induced Heart Damage.
dc.creator.none.fl_str_mv Fernández-Solà, J. (Joaquim)
Planavila Porta, Ana
author Fernández-Solà, J. (Joaquim)
author_facet Fernández-Solà, J. (Joaquim)
Planavila Porta, Ana
author_role author
author2 Planavila Porta, Ana
author2_role author
dc.subject.none.fl_str_mv Malalties cardiovasculars
Apoptosi
Hipertròfia
Alcoholisme
Cardiovascular diseases
Apoptosis
Hypertrophy
Alcoholism
topic Malalties cardiovasculars
Apoptosi
Hipertròfia
Alcoholisme
Cardiovascular diseases
Apoptosis
Hypertrophy
Alcoholism
description High-dose alcohol misuse induces multiple noxious cardiac effects, including myocyte hypertrophy and necrosis, interstitial fibrosis, decreased ventricular contraction and ventricle enlargement. These effects produce diastolic and systolic ventricular dysfunction leading to congestive heart failure, arrhythmias and an increased death rate. There are multiple, dose-dependent, synchronic and synergistic mechanisms of alcohol-induced cardiac damage. Ethanol alters membrane permeability and composition, interferes with receptors and intracellular transients, induces oxidative, metabolic and energy damage, decreases protein synthesis, excitation-contraction coupling and increases cell apoptosis. In addition, ethanol decreases myocyte protective and repair mechanisms and their regeneration. Although there are diverse different strategies to directly target alcohol-induced heart damage, they are partially effective, and can only be used as support medication in a multidisciplinary approach. Alcohol abstinence is the preferred goal, but control drinking is useful in alcohol-addicted subjects not able to abstain. Correction of nutrition, ionic and vitamin deficiencies and control of alcohol-related systemic organ damage are compulsory. Recently, several growth factors (myostatin, IGF-1, leptin, ghrelin, miRNA, and ROCK inhibitors) and new cardiomyokines such as FGF21 have been described to regulate cardiac plasticity and decrease cardiac damage, improving cardiac repair mechanisms, and they are promising agents in this field. New potential therapeutic targets aim to control oxidative damage, myocyte hypertrophy, interstitial fibrosis and persistent apoptosis In addition, stem-cell therapy may improve myocyte regeneration. However, these strategies are not yet approved for clinical use.
publishDate 2016
dc.date.none.fl_str_mv 2016
2017
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/110200
url https://hdl.handle.net/2445/110200
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/ijms17101651
International Journal of Molecular Sciences, 2016, vol. 17, num. 10 , p. E1651-1661
https://doi.org/10.3390/ijms17101651
dc.rights.none.fl_str_mv cc-by (c) Fernández-Solà, J. (Joaquim) et al., 2016
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Fernández-Solà, J. (Joaquim) et al., 2016
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 22 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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