Pseudomonas aeruginosa Performs Chemotaxis to All Major Human Neurotransmitters

The ubiquitous pathogen Pseudomonas aeruginosa is attracted to γ-aminobutyrate (GABA), acetylcholine, histamine, serotonin, epinephrine, norepinephrine, dopamine, tyramine, glycine, and glutamate via chemotaxis. These compounds are all major neurotransmitters in humans. They are also found in variou...

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Detalles Bibliográficos
Autores: Monteagudo-Cascales, Elizabet, Matilla, Miguel A., Udaondo, Zulema, Gavira Gallardo, J. A., Krell, Tino
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/403849
Acceso en línea:http://hdl.handle.net/10261/403849
Access Level:acceso abierto
Palabra clave:Chemoreceptor
Chemotaxis
Neurotransmitter
Pseudomonas aeruginosa
Signal molecule
Signal transduction
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spelling Pseudomonas aeruginosa Performs Chemotaxis to All Major Human NeurotransmittersMonteagudo-Cascales, ElizabetMatilla, Miguel A.Udaondo, ZulemaGavira Gallardo, J. A.Krell, TinoChemoreceptorChemotaxisNeurotransmitterPseudomonas aeruginosaSignal moleculeSignal transductionThe ubiquitous pathogen Pseudomonas aeruginosa is attracted to γ-aminobutyrate (GABA), acetylcholine, histamine, serotonin, epinephrine, norepinephrine, dopamine, tyramine, glycine, and glutamate via chemotaxis. These compounds are all major neurotransmitters in humans. They are also found in various non-neuronal tissues and are synthesised by different organisms, including bacteria, protozoa, invertebrates, and plants. Many of these neurotransmitters increase the expression of virulence-related genes in P. aeruginosa, so that chemotaxis to these compounds may constitute an important virulence factor. The chemotactic response is initiated by the direct binding of these compounds to the dCache ligand-binding domains of the PctC, TlpQ, PctD, PctA, and PctB chemoreceptors. Previous studies have shown that Escherichia coli is attracted to epinephrine, norepinephrine, and dopamine. These responses are mediated by the Tar and Tsr chemoreceptors, which possess four-helix bundle-type ligand-binding domains. The use of structurally dissimilar chemoreceptors to mediate neurotransmitter chemotaxis suggests convergent evolution. This article is intended to stimulate the study of the connection between neurotransmitter chemotaxis and virulence in P. aeruginosa and to expand the search for neurotransmitter chemotaxis in other motile bacteria.This study was supported by grants from the Spanish Ministry for Science, Innovation and Universities/Agencia Estatal de Investigación https://doi.org/10.13039/50110 0011033 and FEDER, UE (grants PID2023-146216NB-I00 to TK, and PID2023- 146281NB-I00 to MAM).Wiley-VCHJohn Wiley & SonsMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)Ministerio de Ciencia e Innovación (España)Federación Española de Enfermedades RarasConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2025202520252025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/403849reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2023-146216NB-I00info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2023-146281NB-I00http://dx.doi.org/10.1111/1751-7915.70211Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4038492026-05-22T06:33:51Z
dc.title.none.fl_str_mv Pseudomonas aeruginosa Performs Chemotaxis to All Major Human Neurotransmitters
title Pseudomonas aeruginosa Performs Chemotaxis to All Major Human Neurotransmitters
spellingShingle Pseudomonas aeruginosa Performs Chemotaxis to All Major Human Neurotransmitters
Monteagudo-Cascales, Elizabet
Chemoreceptor
Chemotaxis
Neurotransmitter
Pseudomonas aeruginosa
Signal molecule
Signal transduction
title_short Pseudomonas aeruginosa Performs Chemotaxis to All Major Human Neurotransmitters
title_full Pseudomonas aeruginosa Performs Chemotaxis to All Major Human Neurotransmitters
title_fullStr Pseudomonas aeruginosa Performs Chemotaxis to All Major Human Neurotransmitters
title_full_unstemmed Pseudomonas aeruginosa Performs Chemotaxis to All Major Human Neurotransmitters
title_sort Pseudomonas aeruginosa Performs Chemotaxis to All Major Human Neurotransmitters
dc.creator.none.fl_str_mv Monteagudo-Cascales, Elizabet
Matilla, Miguel A.
Udaondo, Zulema
Gavira Gallardo, J. A.
Krell, Tino
author Monteagudo-Cascales, Elizabet
author_facet Monteagudo-Cascales, Elizabet
Matilla, Miguel A.
Udaondo, Zulema
Gavira Gallardo, J. A.
Krell, Tino
author_role author
author2 Matilla, Miguel A.
Udaondo, Zulema
Gavira Gallardo, J. A.
Krell, Tino
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
Ministerio de Ciencia e Innovación (España)
Federación Española de Enfermedades Raras
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Chemoreceptor
Chemotaxis
Neurotransmitter
Pseudomonas aeruginosa
Signal molecule
Signal transduction
topic Chemoreceptor
Chemotaxis
Neurotransmitter
Pseudomonas aeruginosa
Signal molecule
Signal transduction
description The ubiquitous pathogen Pseudomonas aeruginosa is attracted to γ-aminobutyrate (GABA), acetylcholine, histamine, serotonin, epinephrine, norepinephrine, dopamine, tyramine, glycine, and glutamate via chemotaxis. These compounds are all major neurotransmitters in humans. They are also found in various non-neuronal tissues and are synthesised by different organisms, including bacteria, protozoa, invertebrates, and plants. Many of these neurotransmitters increase the expression of virulence-related genes in P. aeruginosa, so that chemotaxis to these compounds may constitute an important virulence factor. The chemotactic response is initiated by the direct binding of these compounds to the dCache ligand-binding domains of the PctC, TlpQ, PctD, PctA, and PctB chemoreceptors. Previous studies have shown that Escherichia coli is attracted to epinephrine, norepinephrine, and dopamine. These responses are mediated by the Tar and Tsr chemoreceptors, which possess four-helix bundle-type ligand-binding domains. The use of structurally dissimilar chemoreceptors to mediate neurotransmitter chemotaxis suggests convergent evolution. This article is intended to stimulate the study of the connection between neurotransmitter chemotaxis and virulence in P. aeruginosa and to expand the search for neurotransmitter chemotaxis in other motile bacteria.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/403849
url http://hdl.handle.net/10261/403849
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2023-146216NB-I00
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2023-146281NB-I00
http://dx.doi.org/10.1111/1751-7915.70211
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley-VCH
John Wiley & Sons
publisher.none.fl_str_mv Wiley-VCH
John Wiley & Sons
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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