Abnormal glycemic homeostasis at the onset of serious mental illnesses: A common pathway

Objective: Patients with serious mental illnesses exhibit a reduced lifespan compared with the general population, a finding that can not solely rely on high suicide risk, low access to medical care and unhealthy lifestyle. The main causes of death are medical related pathologies such as type 2 diab...

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Detalles Bibliográficos
Autores: García Rizo, Clemente, Kirkpatrick, Brian, Fernández-Egea, Emilio, Oliveira, Cristina, Bernardo Arroyo, Miquel
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2016
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/130727
Acceso en línea:https://hdl.handle.net/2445/130727
Access Level:acceso abierto
Palabra clave:Trastorn bipolar
Esquizofrènia
Depressió psíquica
Mortalitat
Manic-depressive illness
Schizophrenia
Mental depression
Mortality
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spelling Abnormal glycemic homeostasis at the onset of serious mental illnesses: A common pathwayGarcía Rizo, ClementeKirkpatrick, BrianFernández-Egea, EmilioOliveira, CristinaBernardo Arroyo, MiquelTrastorn bipolarEsquizofrèniaDepressió psíquicaMortalitatManic-depressive illnessSchizophreniaMental depressionMortalityObjective: Patients with serious mental illnesses exhibit a reduced lifespan compared with the general population, a finding that can not solely rely on high suicide risk, low access to medical care and unhealthy lifestyle. The main causes of death are medical related pathologies such as type 2 diabetes mellitus and cardiovascular disease; however pharmacological treatment might play a role. Material and methods: We compared a two hour glucose load in naïve patients at the onset of a serious mental illness (N = 102) (84 patients with a first episode of schizophrenia and related disorders, 6 with a first episode of bipolar I disorder and 12 with a first episode of major depression disorder) with another psychiatric diagnose, adjustment disorder (N = 17) and matched controls (N = 98). Results: Young patients with serious mental illness showed an increased two hour glucose load compared with adjustment disorder and the control group. Mean two hour glucose values [±standard deviation] were: for schizophrenia and related disorders 106.51 mg/dL [±32.0], for bipolar disorder 118.33 mg/dL [±34.3], for major depressive disorder 107.42 mg/dL [±34.5], for adjustment disorder 79.06 mg/dL[±24.4] and for the control group 82.11 mg/dL [±23.3] (p < 0.001). Conclusions: Our results reflect an abnormal metabolic pathway at the onset of the disease before any pharmacological treatment or other confounding factors might have taken place. Our results suggest a similar glycemic pathway in serious mental illnesses and the subsequent need of primary and secondary prevention strategies.Elsevier Ltd2019201920162019info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion14 p.application/pdfhttps://hdl.handle.net/2445/130727Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1016/j.psyneuen.2016.02.001Psychoneuroendocrinology, 2016, vol. 67, p. 70-75https://doi.org/10.1016/j.psyneuen.2016.02.001cc-by-nc-nd (c) Elsevier Ltd, 2016http://creativecommons.org/licenses/by-nc-nd/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1307272026-05-29T05:05:01Z
dc.title.none.fl_str_mv Abnormal glycemic homeostasis at the onset of serious mental illnesses: A common pathway
title Abnormal glycemic homeostasis at the onset of serious mental illnesses: A common pathway
spellingShingle Abnormal glycemic homeostasis at the onset of serious mental illnesses: A common pathway
García Rizo, Clemente
Trastorn bipolar
Esquizofrènia
Depressió psíquica
Mortalitat
Manic-depressive illness
Schizophrenia
Mental depression
Mortality
title_short Abnormal glycemic homeostasis at the onset of serious mental illnesses: A common pathway
title_full Abnormal glycemic homeostasis at the onset of serious mental illnesses: A common pathway
title_fullStr Abnormal glycemic homeostasis at the onset of serious mental illnesses: A common pathway
title_full_unstemmed Abnormal glycemic homeostasis at the onset of serious mental illnesses: A common pathway
title_sort Abnormal glycemic homeostasis at the onset of serious mental illnesses: A common pathway
dc.creator.none.fl_str_mv García Rizo, Clemente
Kirkpatrick, Brian
Fernández-Egea, Emilio
Oliveira, Cristina
Bernardo Arroyo, Miquel
author García Rizo, Clemente
author_facet García Rizo, Clemente
Kirkpatrick, Brian
Fernández-Egea, Emilio
Oliveira, Cristina
Bernardo Arroyo, Miquel
author_role author
author2 Kirkpatrick, Brian
Fernández-Egea, Emilio
Oliveira, Cristina
Bernardo Arroyo, Miquel
author2_role author
author
author
author
dc.subject.none.fl_str_mv Trastorn bipolar
Esquizofrènia
Depressió psíquica
Mortalitat
Manic-depressive illness
Schizophrenia
Mental depression
Mortality
topic Trastorn bipolar
Esquizofrènia
Depressió psíquica
Mortalitat
Manic-depressive illness
Schizophrenia
Mental depression
Mortality
description Objective: Patients with serious mental illnesses exhibit a reduced lifespan compared with the general population, a finding that can not solely rely on high suicide risk, low access to medical care and unhealthy lifestyle. The main causes of death are medical related pathologies such as type 2 diabetes mellitus and cardiovascular disease; however pharmacological treatment might play a role. Material and methods: We compared a two hour glucose load in naïve patients at the onset of a serious mental illness (N = 102) (84 patients with a first episode of schizophrenia and related disorders, 6 with a first episode of bipolar I disorder and 12 with a first episode of major depression disorder) with another psychiatric diagnose, adjustment disorder (N = 17) and matched controls (N = 98). Results: Young patients with serious mental illness showed an increased two hour glucose load compared with adjustment disorder and the control group. Mean two hour glucose values [±standard deviation] were: for schizophrenia and related disorders 106.51 mg/dL [±32.0], for bipolar disorder 118.33 mg/dL [±34.3], for major depressive disorder 107.42 mg/dL [±34.5], for adjustment disorder 79.06 mg/dL[±24.4] and for the control group 82.11 mg/dL [±23.3] (p < 0.001). Conclusions: Our results reflect an abnormal metabolic pathway at the onset of the disease before any pharmacological treatment or other confounding factors might have taken place. Our results suggest a similar glycemic pathway in serious mental illnesses and the subsequent need of primary and secondary prevention strategies.
publishDate 2016
dc.date.none.fl_str_mv 2016
2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/130727
url https://hdl.handle.net/2445/130727
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1016/j.psyneuen.2016.02.001
Psychoneuroendocrinology, 2016, vol. 67, p. 70-75
https://doi.org/10.1016/j.psyneuen.2016.02.001
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Elsevier Ltd, 2016
http://creativecommons.org/licenses/by-nc-nd/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Elsevier Ltd, 2016
http://creativecommons.org/licenses/by-nc-nd/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 14 p.
application/pdf
dc.publisher.none.fl_str_mv Elsevier Ltd
publisher.none.fl_str_mv Elsevier Ltd
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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