Striking structural dynamism and nucleotide sequence variation of the transposon Galileo in the genome of Drosophila mojavensis

Galileo is a transposable element responsible for the generation of three chromosomal inversions in natural populations of Drosophila buzzatii. Although the most characteristic feature of Galileo is the long internally-repetitive terminal inverted repeats (TIRs), which resemble the Drosophila Foldba...

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Autores: Marzo, Mar, Bello, Xabier, Puig Font, Marta|||0000-0002-4439-6372, Maside, Xulio, Ruiz, Alfredo|||0000-0002-3605-5922
Tipo de recurso: artículo
Fecha de publicación:2013
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:184902
Acceso en línea:https://ddd.uab.cat/record/184902
https://dx.doi.org/urn:doi:10.1186/1759-8753-4-6
Access Level:acceso abierto
Palabra clave:Transposable element
Drosophila mojavensis
Evolution
Terminal inverted repeat
Phylogeny
Genomics
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spelling Striking structural dynamism and nucleotide sequence variation of the transposon Galileo in the genome of Drosophila mojavensisMarzo, MarBello, XabierPuig Font, Marta|||0000-0002-4439-6372Maside, XulioRuiz, Alfredo|||0000-0002-3605-5922Transposable elementDrosophila mojavensisEvolutionTerminal inverted repeatPhylogenyGenomicsGalileo is a transposable element responsible for the generation of three chromosomal inversions in natural populations of Drosophila buzzatii. Although the most characteristic feature of Galileo is the long internally-repetitive terminal inverted repeats (TIRs), which resemble the Drosophila Foldback element, its transposase-coding sequence has led to its classification as a member of the P-element superfamily (Class II, subclass 1, TIR order). Furthermore, Galileo has a wide distribution in the genus Drosophila, since it has been found in 6 of the 12 Drosophila sequenced genomes. Among these species, D. mojavensis, the one closest to D. buzzatii, presented the highest diversity in sequence and structure of Galileo elements. In the present work, we carried out a thorough search and annotation of all the Galileo copies present in the D. mojavensis sequenced genome. In our set of 170 Galileo copies we have detected 5 Galileo subfamilies (C, D, E, F, and X) with different structures ranging from nearly complete, to only 2 TIR or solo TIR copies. Finally, we have explored the structural and length variation of the Galileo copies that point out the relatively frequent rearrangements within and between Galileo elements. Different mechanisms responsible for these rearrangements are discussed. Although Galileo is a transposable element with an ancient history in the D. mojavensis genome, our data indicate a recent transpositional activity. Furthermore, the dynamism in sequence and structure, mainly affecting the TIRs, suggests an active exchange of sequences among the copies. This exchange could lead to new subfamilies of the transposon, which could be crucial for the long-term survival of the element in the genome.Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí" 22013-01-0120132013-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/184902https://dx.doi.org/urn:doi:10.1186/1759-8753-4-6reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Ciencia e Innovación https://doi.org/10.13039/501100004837 BFU2008-04988open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/2.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:1849022026-06-06T12:50:31Z
dc.title.none.fl_str_mv Striking structural dynamism and nucleotide sequence variation of the transposon Galileo in the genome of Drosophila mojavensis
title Striking structural dynamism and nucleotide sequence variation of the transposon Galileo in the genome of Drosophila mojavensis
spellingShingle Striking structural dynamism and nucleotide sequence variation of the transposon Galileo in the genome of Drosophila mojavensis
Marzo, Mar
Transposable element
Drosophila mojavensis
Evolution
Terminal inverted repeat
Phylogeny
Genomics
title_short Striking structural dynamism and nucleotide sequence variation of the transposon Galileo in the genome of Drosophila mojavensis
title_full Striking structural dynamism and nucleotide sequence variation of the transposon Galileo in the genome of Drosophila mojavensis
title_fullStr Striking structural dynamism and nucleotide sequence variation of the transposon Galileo in the genome of Drosophila mojavensis
title_full_unstemmed Striking structural dynamism and nucleotide sequence variation of the transposon Galileo in the genome of Drosophila mojavensis
title_sort Striking structural dynamism and nucleotide sequence variation of the transposon Galileo in the genome of Drosophila mojavensis
dc.creator.none.fl_str_mv Marzo, Mar
Bello, Xabier
Puig Font, Marta|||0000-0002-4439-6372
Maside, Xulio
Ruiz, Alfredo|||0000-0002-3605-5922
author Marzo, Mar
author_facet Marzo, Mar
Bello, Xabier
Puig Font, Marta|||0000-0002-4439-6372
Maside, Xulio
Ruiz, Alfredo|||0000-0002-3605-5922
author_role author
author2 Bello, Xabier
Puig Font, Marta|||0000-0002-4439-6372
Maside, Xulio
Ruiz, Alfredo|||0000-0002-3605-5922
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí"
dc.subject.none.fl_str_mv Transposable element
Drosophila mojavensis
Evolution
Terminal inverted repeat
Phylogeny
Genomics
topic Transposable element
Drosophila mojavensis
Evolution
Terminal inverted repeat
Phylogeny
Genomics
description Galileo is a transposable element responsible for the generation of three chromosomal inversions in natural populations of Drosophila buzzatii. Although the most characteristic feature of Galileo is the long internally-repetitive terminal inverted repeats (TIRs), which resemble the Drosophila Foldback element, its transposase-coding sequence has led to its classification as a member of the P-element superfamily (Class II, subclass 1, TIR order). Furthermore, Galileo has a wide distribution in the genus Drosophila, since it has been found in 6 of the 12 Drosophila sequenced genomes. Among these species, D. mojavensis, the one closest to D. buzzatii, presented the highest diversity in sequence and structure of Galileo elements. In the present work, we carried out a thorough search and annotation of all the Galileo copies present in the D. mojavensis sequenced genome. In our set of 170 Galileo copies we have detected 5 Galileo subfamilies (C, D, E, F, and X) with different structures ranging from nearly complete, to only 2 TIR or solo TIR copies. Finally, we have explored the structural and length variation of the Galileo copies that point out the relatively frequent rearrangements within and between Galileo elements. Different mechanisms responsible for these rearrangements are discussed. Although Galileo is a transposable element with an ancient history in the D. mojavensis genome, our data indicate a recent transpositional activity. Furthermore, the dynamism in sequence and structure, mainly affecting the TIRs, suggests an active exchange of sequences among the copies. This exchange could lead to new subfamilies of the transposon, which could be crucial for the long-term survival of the element in the genome.
publishDate 2013
dc.date.none.fl_str_mv 2
2013-01-01
2013
2013-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/184902
https://dx.doi.org/urn:doi:10.1186/1759-8753-4-6
url https://ddd.uab.cat/record/184902
https://dx.doi.org/urn:doi:10.1186/1759-8753-4-6
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 BFU2008-04988
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/2.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/2.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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