Sex Differences in Plasma Lysophosphatidic Acid Species in Patients with Alcohol and Cocaine Use Disorders

Preclinical evidence suggests a main role of lysophosphatidic acid (LPA) signaling in drug addiction. Recently, we reported alterations in the plasma concentrations of LPA species in patients with alcohol use disorder (AUD). As there are sex differences in drug addiction, the main aim of the present...

Descripción completa

Detalles Bibliográficos
Autores: Flores López, María, García Marchena, Nuria, Araos, Pedro, Requena Ocaña, Nerea, Porras Perales, Oscar, Torres Galván, Sandra, Suarez, Juan, Pizarro, Nieves, Torre, Rafael de la, Rubio, Gabriel, Ruiz Ruiz, Juan Jesús, Rodríguez De Fonseca, Fernando Antonio, Serrano, Antonia, Pavón Morón, Francisco Javier
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/71617
Acceso en línea:https://hdl.handle.net/20.500.14352/71617
Access Level:acceso abierto
Palabra clave:lysophosphatidic acid
biomarker
sex
substance use disorder
alcohol
cocaine
Bioquímica (Medicina)
Toxicomanía (Psicología)
id ES_ea1bfa88d7be2002dd79134d696544f2
oai_identifier_str oai:docta.ucm.es:20.500.14352/71617
network_acronym_str ES
network_name_str España
repository_id_str
spelling Sex Differences in Plasma Lysophosphatidic Acid Species in Patients with Alcohol and Cocaine Use DisordersFlores López, MaríaGarcía Marchena, NuriaAraos, PedroRequena Ocaña, NereaPorras Perales, OscarTorres Galván, SandraSuarez, JuanPizarro, NievesTorre, Rafael de laRubio, GabrielRuiz Ruiz, Juan JesúsRodríguez De Fonseca, Fernando AntonioSerrano, AntoniaPavón Morón, Francisco Javierlysophosphatidic acidbiomarkersexsubstance use disorderalcoholcocaineBioquímica (Medicina)Toxicomanía (Psicología)Preclinical evidence suggests a main role of lysophosphatidic acid (LPA) signaling in drug addiction. Recently, we reported alterations in the plasma concentrations of LPA species in patients with alcohol use disorder (AUD). As there are sex differences in drug addiction, the main aim of the present study was to investigate whether relevant LPA species (16:0-LPA, 18:0-LPA, 18:1-LPA, 18:2-LPA and 20:4-LPA) were associated with sex and/or substance use disorder (SUD). This exploratory study was conducted in 214 abstinent patients with lifetime SUD, and 91 healthy control subjects. The SUD group was divided according to the diagnosis of AUD and/or cocaine use disorder (CUD). Participants were clinically assessed, and plasma samples were collected to determine LPA species and total LPA. We found that LPA concentrations were significantly affected by sex, and women showed higher concentrations than men. In addition, there were significantly lower 16:0-LPA, 18:2-LPA and total LPA concentrations in patients with SUD than in controls. Namely, patients with CUD and AUD + CUD showed lower LPA concentrations than controls or patients with AUD. In conclusion, our data suggest that LPA species could be potential biomarkers for SUD in women and men, which could contribute to a better stratification of these patients in treatment programs.MPDIUniversidad Complutense de Madrid20222022-01-0120222022-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/71617reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/716172026-06-02T12:44:21Z
dc.title.none.fl_str_mv Sex Differences in Plasma Lysophosphatidic Acid Species in Patients with Alcohol and Cocaine Use Disorders
title Sex Differences in Plasma Lysophosphatidic Acid Species in Patients with Alcohol and Cocaine Use Disorders
spellingShingle Sex Differences in Plasma Lysophosphatidic Acid Species in Patients with Alcohol and Cocaine Use Disorders
Flores López, María
lysophosphatidic acid
biomarker
sex
substance use disorder
alcohol
cocaine
Bioquímica (Medicina)
Toxicomanía (Psicología)
title_short Sex Differences in Plasma Lysophosphatidic Acid Species in Patients with Alcohol and Cocaine Use Disorders
title_full Sex Differences in Plasma Lysophosphatidic Acid Species in Patients with Alcohol and Cocaine Use Disorders
title_fullStr Sex Differences in Plasma Lysophosphatidic Acid Species in Patients with Alcohol and Cocaine Use Disorders
title_full_unstemmed Sex Differences in Plasma Lysophosphatidic Acid Species in Patients with Alcohol and Cocaine Use Disorders
title_sort Sex Differences in Plasma Lysophosphatidic Acid Species in Patients with Alcohol and Cocaine Use Disorders
dc.creator.none.fl_str_mv Flores López, María
García Marchena, Nuria
Araos, Pedro
Requena Ocaña, Nerea
Porras Perales, Oscar
Torres Galván, Sandra
Suarez, Juan
Pizarro, Nieves
Torre, Rafael de la
Rubio, Gabriel
Ruiz Ruiz, Juan Jesús
Rodríguez De Fonseca, Fernando Antonio
Serrano, Antonia
Pavón Morón, Francisco Javier
author Flores López, María
author_facet Flores López, María
García Marchena, Nuria
Araos, Pedro
Requena Ocaña, Nerea
Porras Perales, Oscar
Torres Galván, Sandra
Suarez, Juan
Pizarro, Nieves
Torre, Rafael de la
Rubio, Gabriel
Ruiz Ruiz, Juan Jesús
Rodríguez De Fonseca, Fernando Antonio
Serrano, Antonia
Pavón Morón, Francisco Javier
author_role author
author2 García Marchena, Nuria
Araos, Pedro
Requena Ocaña, Nerea
Porras Perales, Oscar
Torres Galván, Sandra
Suarez, Juan
Pizarro, Nieves
Torre, Rafael de la
Rubio, Gabriel
Ruiz Ruiz, Juan Jesús
Rodríguez De Fonseca, Fernando Antonio
Serrano, Antonia
Pavón Morón, Francisco Javier
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv lysophosphatidic acid
biomarker
sex
substance use disorder
alcohol
cocaine
Bioquímica (Medicina)
Toxicomanía (Psicología)
topic lysophosphatidic acid
biomarker
sex
substance use disorder
alcohol
cocaine
Bioquímica (Medicina)
Toxicomanía (Psicología)
description Preclinical evidence suggests a main role of lysophosphatidic acid (LPA) signaling in drug addiction. Recently, we reported alterations in the plasma concentrations of LPA species in patients with alcohol use disorder (AUD). As there are sex differences in drug addiction, the main aim of the present study was to investigate whether relevant LPA species (16:0-LPA, 18:0-LPA, 18:1-LPA, 18:2-LPA and 20:4-LPA) were associated with sex and/or substance use disorder (SUD). This exploratory study was conducted in 214 abstinent patients with lifetime SUD, and 91 healthy control subjects. The SUD group was divided according to the diagnosis of AUD and/or cocaine use disorder (CUD). Participants were clinically assessed, and plasma samples were collected to determine LPA species and total LPA. We found that LPA concentrations were significantly affected by sex, and women showed higher concentrations than men. In addition, there were significantly lower 16:0-LPA, 18:2-LPA and total LPA concentrations in patients with SUD than in controls. Namely, patients with CUD and AUD + CUD showed lower LPA concentrations than controls or patients with AUD. In conclusion, our data suggest that LPA species could be potential biomarkers for SUD in women and men, which could contribute to a better stratification of these patients in treatment programs.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-01-01
2022
2022-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/71617
url https://hdl.handle.net/20.500.14352/71617
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MPDI
publisher.none.fl_str_mv MPDI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869423111030439936
score 15.301603

Similares en LA Referencia