Interaction of gonadal hormones, dopaminergic system, and epigenetic regulation in the generation of sex differences in substance use disorders: A systematic review

Substance use disorder (SUD) is a chronic condition characterized by pathological drug-taking and seeking behaviors. Remarkably different between males and females, suggesting that drug addiction is a sexually differentiated disorder. The neurobiological bases of sex differences in SUD include sex-s...

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Detalhes bibliográficos
Autores: Santos Toscano, Raquel, Arevalo, Maria Angeles, Garcia Segura, Luis Miguel, Grassi, Daniela, Lagunas, Natalia
Formato: artículo
Fecha de publicación:2023
País:España
Recursos:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/708688
Acesso em linha:http://hdl.handle.net/10486/708688
https://dx.doi.org/10.1016/j.yfrne.2023.101085
Access Level:acceso abierto
Palavra-chave:Brain reward
Dopaminergic system
Epigenetics
Gonadal hormones
Sex differences
Substance use disorder
Medicina
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spelling Interaction of gonadal hormones, dopaminergic system, and epigenetic regulation in the generation of sex differences in substance use disorders: A systematic reviewSantos Toscano, RaquelArevalo, Maria AngelesGarcia Segura, Luis MiguelGrassi, DanielaLagunas, NataliaBrain rewardDopaminergic systemEpigeneticsGonadal hormonesSex differencesSubstance use disorderMedicinaSubstance use disorder (SUD) is a chronic condition characterized by pathological drug-taking and seeking behaviors. Remarkably different between males and females, suggesting that drug addiction is a sexually differentiated disorder. The neurobiological bases of sex differences in SUD include sex-specific reward system activation, influenced by interactions between gonadal hormone level changes, dopaminergic reward circuits, and epigenetic modifications of key reward system genes. This systematic review, adhering to PICOS and PRISMA-P 2015 guidelines, highlights the sex-dependent roles of estrogens, progesterone, and testosterone in SUD. In particular, estradiol elevates and progesterone reduces dopaminergic activity in SUD females, whilst testosterone and progesterone augment SUD behavior in males. Finally, SUD is associated with a sex-specific increase in the rate of opioid and monoaminergic gene methylation. The study reveals the need for detailed research on gonadal hormone levels, dopaminergic or reward system activity, and epigenetic landscapes in both sexes for efficient SUD therapy developmentThis work was supported by the Agencia Estatal de Investigacion, ´ Spain, and Fondo Europeo de Desarrollo Regional (FEDER) [PID2020-115019RB-I00; PID2021-125039NB-I00], Universidad Autonoma ´ de Madrid – Comunidad Autonoma ´ de Madrid, Programa de estímulo a la investigacion ´ de jovenes ´ doctores (Project SI3/PJI/2021-00508), Centro de Investigacion ´ Biom´edica en Red Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, MadridElsevierDepartamento de Anatomía, Histología y NeurocienciaFacultad de Medicina20232023-08-04research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/708688https://dx.doi.org/10.1016/j.yfrne.2023.101085reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/7086882026-06-23T12:46:27Z
dc.title.none.fl_str_mv Interaction of gonadal hormones, dopaminergic system, and epigenetic regulation in the generation of sex differences in substance use disorders: A systematic review
title Interaction of gonadal hormones, dopaminergic system, and epigenetic regulation in the generation of sex differences in substance use disorders: A systematic review
spellingShingle Interaction of gonadal hormones, dopaminergic system, and epigenetic regulation in the generation of sex differences in substance use disorders: A systematic review
Santos Toscano, Raquel
Brain reward
Dopaminergic system
Epigenetics
Gonadal hormones
Sex differences
Substance use disorder
Medicina
title_short Interaction of gonadal hormones, dopaminergic system, and epigenetic regulation in the generation of sex differences in substance use disorders: A systematic review
title_full Interaction of gonadal hormones, dopaminergic system, and epigenetic regulation in the generation of sex differences in substance use disorders: A systematic review
title_fullStr Interaction of gonadal hormones, dopaminergic system, and epigenetic regulation in the generation of sex differences in substance use disorders: A systematic review
title_full_unstemmed Interaction of gonadal hormones, dopaminergic system, and epigenetic regulation in the generation of sex differences in substance use disorders: A systematic review
title_sort Interaction of gonadal hormones, dopaminergic system, and epigenetic regulation in the generation of sex differences in substance use disorders: A systematic review
dc.creator.none.fl_str_mv Santos Toscano, Raquel
Arevalo, Maria Angeles
Garcia Segura, Luis Miguel
Grassi, Daniela
Lagunas, Natalia
author Santos Toscano, Raquel
author_facet Santos Toscano, Raquel
Arevalo, Maria Angeles
Garcia Segura, Luis Miguel
Grassi, Daniela
Lagunas, Natalia
author_role author
author2 Arevalo, Maria Angeles
Garcia Segura, Luis Miguel
Grassi, Daniela
Lagunas, Natalia
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Anatomía, Histología y Neurociencia
Facultad de Medicina
dc.subject.none.fl_str_mv Brain reward
Dopaminergic system
Epigenetics
Gonadal hormones
Sex differences
Substance use disorder
Medicina
topic Brain reward
Dopaminergic system
Epigenetics
Gonadal hormones
Sex differences
Substance use disorder
Medicina
description Substance use disorder (SUD) is a chronic condition characterized by pathological drug-taking and seeking behaviors. Remarkably different between males and females, suggesting that drug addiction is a sexually differentiated disorder. The neurobiological bases of sex differences in SUD include sex-specific reward system activation, influenced by interactions between gonadal hormone level changes, dopaminergic reward circuits, and epigenetic modifications of key reward system genes. This systematic review, adhering to PICOS and PRISMA-P 2015 guidelines, highlights the sex-dependent roles of estrogens, progesterone, and testosterone in SUD. In particular, estradiol elevates and progesterone reduces dopaminergic activity in SUD females, whilst testosterone and progesterone augment SUD behavior in males. Finally, SUD is associated with a sex-specific increase in the rate of opioid and monoaminergic gene methylation. The study reveals the need for detailed research on gonadal hormone levels, dopaminergic or reward system activity, and epigenetic landscapes in both sexes for efficient SUD therapy development
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-08-04
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/708688
https://dx.doi.org/10.1016/j.yfrne.2023.101085
url http://hdl.handle.net/10486/708688
https://dx.doi.org/10.1016/j.yfrne.2023.101085
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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