The lipocalin apolipoprotein D functional portrait: A systematic review

© 2021 Sanchez and Ganfornina.

Detalles Bibliográficos
Autores: Sánchez, Diego, Ganfornina, M. D.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/260873
Acceso en línea:http://hdl.handle.net/10261/260873
Access Level:acceso abierto
Palabra clave:Protein physiology
Lipid peroxidation
Membrane management
Oxidative stress
Lipoprotein particles
Extracellular vesicles
Lysosome
ApoD
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spelling The lipocalin apolipoprotein D functional portrait: A systematic reviewSánchez, DiegoGanfornina, M. D.Protein physiologyLipid peroxidationMembrane managementOxidative stressLipoprotein particlesExtracellular vesiclesLysosomeApoD© 2021 Sanchez and Ganfornina.Apolipoprotein D is a chordate gene early originated in the Lipocalin protein family. Among other features, regulation of its expression in a wide variety of disease conditions in humans, as apparently unrelated as neurodegeneration or breast cancer, have called for attention on this gene. Also, its presence in different tissues, from blood to brain, and different subcellular locations, from HDL lipoparticles to the interior of lysosomes or the surface of extracellular vesicles, poses an interesting challenge in deciphering its physiological function: Is ApoD a moonlighting protein, serving different roles in different cellular compartments, tissues, or organisms? Or does it have a unique biochemical mechanism of action that accounts for such apparently diverse roles in different physiological situations? To answer these questions, we have performed a systematic review of all primary publications where ApoD properties have been investigated in chordates. We conclude that ApoD ligand binding in the Lipocalin pocket, combined with an antioxidant activity performed at the rim of the pocket are properties sufficient to explain ApoD association with different lipid-based structures, where its physiological function is better described as lipid-management than by long-range lipid-transport. Controlling the redox state of these lipid structures in particular subcellular locations or extracellular structures, ApoD is able to modulate an enormous array of apparently diverse processes in the organism, both in health and disease. The new picture emerging from these data should help to put the physiological role of ApoD in new contexts and to inspire well-focused future research.This work was supported by a Ministerio de Ciencia e Innovacion grant PID2019-110911RB-I00 to MG and DS.Frontiers MediaMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2022202220212022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/260873reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-110911RB-I00http://dx.doi.org/10.3389/fphys.2021.738991Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2608732026-05-22T06:33:51Z
dc.title.none.fl_str_mv The lipocalin apolipoprotein D functional portrait: A systematic review
title The lipocalin apolipoprotein D functional portrait: A systematic review
spellingShingle The lipocalin apolipoprotein D functional portrait: A systematic review
Sánchez, Diego
Protein physiology
Lipid peroxidation
Membrane management
Oxidative stress
Lipoprotein particles
Extracellular vesicles
Lysosome
ApoD
title_short The lipocalin apolipoprotein D functional portrait: A systematic review
title_full The lipocalin apolipoprotein D functional portrait: A systematic review
title_fullStr The lipocalin apolipoprotein D functional portrait: A systematic review
title_full_unstemmed The lipocalin apolipoprotein D functional portrait: A systematic review
title_sort The lipocalin apolipoprotein D functional portrait: A systematic review
dc.creator.none.fl_str_mv Sánchez, Diego
Ganfornina, M. D.
author Sánchez, Diego
author_facet Sánchez, Diego
Ganfornina, M. D.
author_role author
author2 Ganfornina, M. D.
author2_role author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Protein physiology
Lipid peroxidation
Membrane management
Oxidative stress
Lipoprotein particles
Extracellular vesicles
Lysosome
ApoD
topic Protein physiology
Lipid peroxidation
Membrane management
Oxidative stress
Lipoprotein particles
Extracellular vesicles
Lysosome
ApoD
description © 2021 Sanchez and Ganfornina.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/260873
url http://hdl.handle.net/10261/260873
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-110911RB-I00
http://dx.doi.org/10.3389/fphys.2021.738991
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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