Oxygen-generating and antibacterial xanthan gum/PLA aerogels loaded with dexamethasone for potential wound healing

Chronic wounds do not heal within a reasonable time frame due to hypoxia and bacterial inflammation, creating an urgent need for advanced biomaterials to address these challenges. In this study, oxygen-generating, antibacterial xanthan gum-polylactic acid (XA/PLA) aerogels loaded with dexamethasone...

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Autores: Hozjan, Nika Atelšek, Horvat, Gabrijela, Finšgar, MMatjaž, Iglesias-Mejuto, Ana, Ardao Palacios, Inés, García González, Carlos A., Knez, Zeljko A., Novak, Zoran
Formato: artículo
Fecha de publicación:2025
País:España
Recursos:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:dnet:minerva_____::f8c8f32a16995f2a796fc73dea48b3b7
Acesso em linha:https://hdl.handle.net/10347/47194
Access Level:acceso abierto
Palavra-chave:Aerogel
Wound healing
Xanthan gum
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spelling Oxygen-generating and antibacterial xanthan gum/PLA aerogels loaded with dexamethasone for potential wound healingHozjan, Nika AtelšekHorvat, GabrijelaFinšgar, MMatjažIglesias-Mejuto, AnaArdao Palacios, InésGarcía González, Carlos A.Knez, Zeljko A.Novak, ZoranAerogelWound healingXanthan gumChronic wounds do not heal within a reasonable time frame due to hypoxia and bacterial inflammation, creating an urgent need for advanced biomaterials to address these challenges. In this study, oxygen-generating, antibacterial xanthan gum-polylactic acid (XA/PLA) aerogels loaded with dexamethasone were developed for the first time for potential wound healing applications. The aerogels contained sodium percarbonate and calcium peroxide as oxygen-releasing agents, providing sustained oxygen release for up to 48 h. The aerogels had a highly porous structure with a high specific surface area (up to 396 ± 8 m2/g) and revealed high liquid absorption capacity in simulated body fluid, absorbing up to 67 times their original weight and remaining stable for 72 h. The in vitro release tests showed controlled profiles of dexamethasone over 24 h. The antibacterial tests demonstrated strong antibacterial activity against Escherichia coli (an up to 15.92 mm inhibition zone diameter) and Staphylococcus aureus (up to a 31.07 mm inhibition zone diameter). The in vitro biocompatibility assays revealed good cytocompatibility with mouse fibroblast cells (NIH/3T3), with a cell viability of >90%. Hemocompatibility tests showed no hemolytic activity with human blood (lysis rate <2%). Overall, these results emphasise the versatility of the XA/PLA aerogels and their potential for the treatment of chronic wounds.ElsevierUniversidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía FarmacéuticaUniversidade de Santiago de Compostela. Instituto de Materiais (iMATUS)20252025-04-1920252025-04-19journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10347/47194reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)InglésengAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PID2020-120010RB-I00 INGENIERIA DE AEROGELES PARA APLICACIONES BIOMEDICAS AVANZADASAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023 PDC2022-133526-I00 DESARROLLO DE PROTOTIPO AVANZADO PARA LA ESTERILIZACION DE PRODUCTOS SANITARIOS Y MEDICAMENTOSopen accesshttp://purl.org/coar/access_right/c_abf2© 2025 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:dnet:minerva_____::f8c8f32a16995f2a796fc73dea48b3b72026-06-15T12:47:27Z
dc.title.none.fl_str_mv Oxygen-generating and antibacterial xanthan gum/PLA aerogels loaded with dexamethasone for potential wound healing
title Oxygen-generating and antibacterial xanthan gum/PLA aerogels loaded with dexamethasone for potential wound healing
spellingShingle Oxygen-generating and antibacterial xanthan gum/PLA aerogels loaded with dexamethasone for potential wound healing
Hozjan, Nika Atelšek
Aerogel
Wound healing
Xanthan gum
title_short Oxygen-generating and antibacterial xanthan gum/PLA aerogels loaded with dexamethasone for potential wound healing
title_full Oxygen-generating and antibacterial xanthan gum/PLA aerogels loaded with dexamethasone for potential wound healing
title_fullStr Oxygen-generating and antibacterial xanthan gum/PLA aerogels loaded with dexamethasone for potential wound healing
title_full_unstemmed Oxygen-generating and antibacterial xanthan gum/PLA aerogels loaded with dexamethasone for potential wound healing
title_sort Oxygen-generating and antibacterial xanthan gum/PLA aerogels loaded with dexamethasone for potential wound healing
dc.creator.none.fl_str_mv Hozjan, Nika Atelšek
Horvat, Gabrijela
Finšgar, MMatjaž
Iglesias-Mejuto, Ana
Ardao Palacios, Inés
García González, Carlos A.
Knez, Zeljko A.
Novak, Zoran
author Hozjan, Nika Atelšek
author_facet Hozjan, Nika Atelšek
Horvat, Gabrijela
Finšgar, MMatjaž
Iglesias-Mejuto, Ana
Ardao Palacios, Inés
García González, Carlos A.
Knez, Zeljko A.
Novak, Zoran
author_role author
author2 Horvat, Gabrijela
Finšgar, MMatjaž
Iglesias-Mejuto, Ana
Ardao Palacios, Inés
García González, Carlos A.
Knez, Zeljko A.
Novak, Zoran
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica
Universidade de Santiago de Compostela. Instituto de Materiais (iMATUS)
dc.subject.none.fl_str_mv Aerogel
Wound healing
Xanthan gum
topic Aerogel
Wound healing
Xanthan gum
description Chronic wounds do not heal within a reasonable time frame due to hypoxia and bacterial inflammation, creating an urgent need for advanced biomaterials to address these challenges. In this study, oxygen-generating, antibacterial xanthan gum-polylactic acid (XA/PLA) aerogels loaded with dexamethasone were developed for the first time for potential wound healing applications. The aerogels contained sodium percarbonate and calcium peroxide as oxygen-releasing agents, providing sustained oxygen release for up to 48 h. The aerogels had a highly porous structure with a high specific surface area (up to 396 ± 8 m2/g) and revealed high liquid absorption capacity in simulated body fluid, absorbing up to 67 times their original weight and remaining stable for 72 h. The in vitro release tests showed controlled profiles of dexamethasone over 24 h. The antibacterial tests demonstrated strong antibacterial activity against Escherichia coli (an up to 15.92 mm inhibition zone diameter) and Staphylococcus aureus (up to a 31.07 mm inhibition zone diameter). The in vitro biocompatibility assays revealed good cytocompatibility with mouse fibroblast cells (NIH/3T3), with a cell viability of >90%. Hemocompatibility tests showed no hemolytic activity with human blood (lysis rate <2%). Overall, these results emphasise the versatility of the XA/PLA aerogels and their potential for the treatment of chronic wounds.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-04-19
2025
2025-04-19
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10347/47194
url https://hdl.handle.net/10347/47194
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PID2020-120010RB-I00 INGENIERIA DE AEROGELES PARA APLICACIONES BIOMEDICAS AVANZADAS
Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023 PDC2022-133526-I00 DESARROLLO DE PROTOTIPO AVANZADO PARA LA ESTERILIZACION DE PRODUCTOS SANITARIOS Y MEDICAMENTOS
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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