Trimethylamine N -Oxide

Recent evidence, including massive gene-expression analysis and a wide-variety of other multi-omics approaches, demonstrates an interplay between gut microbiota and the regulation of plasma lipids. Gut microbial metabolism of choline and -carnitine results in the formation of trimethylamine (TMA) an...

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Autores: Canyelles, Marina|||0000-0002-0278-5337, Tondo Colomer, Mireia|||0000-0002-0301-9984, Cedó, Lídia|||0000-0003-4354-3411, Farràs Mañé, Marta|||0000-0001-9776-3773, Escolà-Gil, Joan Carles|||0000-0001-9021-2485, Blanco Vaca, Francisco|||0000-0001-7380-5385
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:253687
Acceso en línea:https://ddd.uab.cat/record/253687
https://dx.doi.org/urn:doi:10.3390/ijms19103228
Access Level:acceso abierto
Palabra clave:Trimethylamine
Trimethylamine- N -oxide
Intestinal microbiota
FMO3
Reverse cholesterol transport
Cholesterol homeostasis
Atherosclerosis and cardiovascular disease
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spelling Trimethylamine N -OxideA Link among Diet, Gut Microbiota, Gene Regulation of Liver and Intestine Cholesterol Homeostasis and HDL FunctionCanyelles, Marina|||0000-0002-0278-5337Tondo Colomer, Mireia|||0000-0002-0301-9984Cedó, Lídia|||0000-0003-4354-3411Farràs Mañé, Marta|||0000-0001-9776-3773Escolà-Gil, Joan Carles|||0000-0001-9021-2485Blanco Vaca, Francisco|||0000-0001-7380-5385TrimethylamineTrimethylamine- N -oxideIntestinal microbiotaFMO3Reverse cholesterol transportCholesterol homeostasisAtherosclerosis and cardiovascular diseaseRecent evidence, including massive gene-expression analysis and a wide-variety of other multi-omics approaches, demonstrates an interplay between gut microbiota and the regulation of plasma lipids. Gut microbial metabolism of choline and -carnitine results in the formation of trimethylamine (TMA) and concomitant conversion into trimethylamine- N -oxide (TMAO) by liver flavin monooxygenase 3 (FMO3). The plasma level of TMAO is determined by the genetic variation, diet and composition of gut microbiota. Multiple studies have demonstrated an association between TMAO plasma levels and the risk of atherothrombotic cardiovascular disease (CVD). We aimed to review the molecular pathways by which TMAO production and FMO3 exert their proatherogenic effects. TMAO may promote foam cell formation by upregulating macrophage scavenger receptors, deregulating enterohepatic cholesterol and bile acid metabolism and impairing macrophage reverse cholesterol transport (RCT). Furthermore, FMO3 may promote dyslipidemia by regulating multiple genes involved in hepatic lipogenesis and gluconeogenesis. FMO3 also impairs multiple aspects of cholesterol homeostasis, including transintestinal cholesterol export and macrophage-specific RCT. At least part of these FMO3-mediated effects on lipid metabolism and atherogenesis seem to be independent of the TMA/TMAO formation. Overall, these findings have the potential to open a new era for the therapeutic manipulation of the gut microbiota to improve CVD risk. 22018-01-0120182018-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/253687https://dx.doi.org/urn:doi:10.3390/ijms19103228reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 FIS16-00139Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 CD17/00233open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2536872026-06-06T12:50:31Z
dc.title.none.fl_str_mv Trimethylamine N -Oxide
A Link among Diet, Gut Microbiota, Gene Regulation of Liver and Intestine Cholesterol Homeostasis and HDL Function
title Trimethylamine N -Oxide
spellingShingle Trimethylamine N -Oxide
Canyelles, Marina|||0000-0002-0278-5337
Trimethylamine
Trimethylamine- N -oxide
Intestinal microbiota
FMO3
Reverse cholesterol transport
Cholesterol homeostasis
Atherosclerosis and cardiovascular disease
title_short Trimethylamine N -Oxide
title_full Trimethylamine N -Oxide
title_fullStr Trimethylamine N -Oxide
title_full_unstemmed Trimethylamine N -Oxide
title_sort Trimethylamine N -Oxide
dc.creator.none.fl_str_mv Canyelles, Marina|||0000-0002-0278-5337
Tondo Colomer, Mireia|||0000-0002-0301-9984
Cedó, Lídia|||0000-0003-4354-3411
Farràs Mañé, Marta|||0000-0001-9776-3773
Escolà-Gil, Joan Carles|||0000-0001-9021-2485
Blanco Vaca, Francisco|||0000-0001-7380-5385
author Canyelles, Marina|||0000-0002-0278-5337
author_facet Canyelles, Marina|||0000-0002-0278-5337
Tondo Colomer, Mireia|||0000-0002-0301-9984
Cedó, Lídia|||0000-0003-4354-3411
Farràs Mañé, Marta|||0000-0001-9776-3773
Escolà-Gil, Joan Carles|||0000-0001-9021-2485
Blanco Vaca, Francisco|||0000-0001-7380-5385
author_role author
author2 Tondo Colomer, Mireia|||0000-0002-0301-9984
Cedó, Lídia|||0000-0003-4354-3411
Farràs Mañé, Marta|||0000-0001-9776-3773
Escolà-Gil, Joan Carles|||0000-0001-9021-2485
Blanco Vaca, Francisco|||0000-0001-7380-5385
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Trimethylamine
Trimethylamine- N -oxide
Intestinal microbiota
FMO3
Reverse cholesterol transport
Cholesterol homeostasis
Atherosclerosis and cardiovascular disease
topic Trimethylamine
Trimethylamine- N -oxide
Intestinal microbiota
FMO3
Reverse cholesterol transport
Cholesterol homeostasis
Atherosclerosis and cardiovascular disease
description Recent evidence, including massive gene-expression analysis and a wide-variety of other multi-omics approaches, demonstrates an interplay between gut microbiota and the regulation of plasma lipids. Gut microbial metabolism of choline and -carnitine results in the formation of trimethylamine (TMA) and concomitant conversion into trimethylamine- N -oxide (TMAO) by liver flavin monooxygenase 3 (FMO3). The plasma level of TMAO is determined by the genetic variation, diet and composition of gut microbiota. Multiple studies have demonstrated an association between TMAO plasma levels and the risk of atherothrombotic cardiovascular disease (CVD). We aimed to review the molecular pathways by which TMAO production and FMO3 exert their proatherogenic effects. TMAO may promote foam cell formation by upregulating macrophage scavenger receptors, deregulating enterohepatic cholesterol and bile acid metabolism and impairing macrophage reverse cholesterol transport (RCT). Furthermore, FMO3 may promote dyslipidemia by regulating multiple genes involved in hepatic lipogenesis and gluconeogenesis. FMO3 also impairs multiple aspects of cholesterol homeostasis, including transintestinal cholesterol export and macrophage-specific RCT. At least part of these FMO3-mediated effects on lipid metabolism and atherogenesis seem to be independent of the TMA/TMAO formation. Overall, these findings have the potential to open a new era for the therapeutic manipulation of the gut microbiota to improve CVD risk.
publishDate 2018
dc.date.none.fl_str_mv 2
2018-01-01
2018
2018-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/253687
https://dx.doi.org/urn:doi:10.3390/ijms19103228
url https://ddd.uab.cat/record/253687
https://dx.doi.org/urn:doi:10.3390/ijms19103228
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 FIS16-00139
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 CD17/00233
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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