Ultrathin Polymeric Platform for Drug-Eluting Stent: A proof of concept

Recent innovations in Drug-Eluting Stents (DES) technology have led to the development of new stents with further reduction in strut width, the ultrathin DES, with struts thinner than 70 µm. Ultrathin DES may further improve the efficacy and safety profile of Percutaneous Coronary Intervention (PCI)...

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Autores: Bosch Collell, Aniol, Casanova Batlle, Enric, Ausellé i Bosch, Sira, Polonio Alcalá, Emma, Puig i Miquel, Teresa, Ciurana, Quim de, Guerra Sánchez, Antonio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10256/26168
Acceso en línea:http://hdl.handle.net/10256/26168
Access Level:acceso abierto
Palabra clave:Pròtesis de Stent
Stents (Surgery)
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spelling Ultrathin Polymeric Platform for Drug-Eluting Stent: A proof of conceptBosch Collell, AniolCasanova Batlle, EnricAusellé i Bosch, SiraPolonio Alcalá, EmmaPuig i Miquel, TeresaCiurana, Quim deGuerra Sánchez, AntonioPròtesis de StentStents (Surgery)Recent innovations in Drug-Eluting Stents (DES) technology have led to the development of new stents with further reduction in strut width, the ultrathin DES, with struts thinner than 70 µm. Ultrathin DES may further improve the efficacy and safety profile of Percutaneous Coronary Intervention (PCI) by reducing the risk of target-lesion and target-vessel failures compared to the current-generation DES. However, the ultrathin DES metallic platform still presents some associated problems, such as biofilm formation, infection, and migration, all related to the cellular response. The present work aims to produce an ultrathin permanent polymeric platform for a new generation of polymeric drug-eluting stents (PDES). In this work, the cellular response was compared with the traditional stainless steel (SS316L) and polycaprolactone (PCL) to determine whether these polymers could address this challenge. An innovative method of tubular 3D micro stereolithography tubular (ST3DT) was used. Different PDES platforms were fabricated with different polymeric materials (based on polyurethane and urethane dimethacrylate). Subsequently, HFL1 fibroblasts were seeded on the PDES, PCL and SS316L for 3 days. The findings from the assays of cell biocompatibility and proliferation (75%PCL), coupled with the successful fabrication of stent struts below 70 µm using the Surgical Guide resin and the ST3DT method, suggest that resin is a promising candidate for a PDESElsevier2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionpeer-reviewed6 p.application/pdfhttp://hdl.handle.net/10256/26168Procedia CIRP, 2024, vol. 125, p. 243-248Articles publicats (D-EMCI)Bosch Collell, Aniol Casanova Batlle, Enric Ausellé Bosch, Sira Polonio Alcalá, Emma Puig i Miquel, Teresa Ciurana, Quim de Guerra Sánchez, Antonio 2024 Ultrathin Polymeric Platform for Drug-Eluting Stent: A proof of concept Procedia CIRP 125 243 248reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.procir.2024.08.042info:eu-repo/semantics/altIdentifier/issn/2212-8271Reconeixement-NoComercial-SenseObraDerivada 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0info:eu-repo/semantics/openAccessoai:recercat.cat:10256/261682026-05-29T05:05:01Z
dc.title.none.fl_str_mv Ultrathin Polymeric Platform for Drug-Eluting Stent: A proof of concept
title Ultrathin Polymeric Platform for Drug-Eluting Stent: A proof of concept
spellingShingle Ultrathin Polymeric Platform for Drug-Eluting Stent: A proof of concept
Bosch Collell, Aniol
Pròtesis de Stent
Stents (Surgery)
title_short Ultrathin Polymeric Platform for Drug-Eluting Stent: A proof of concept
title_full Ultrathin Polymeric Platform for Drug-Eluting Stent: A proof of concept
title_fullStr Ultrathin Polymeric Platform for Drug-Eluting Stent: A proof of concept
title_full_unstemmed Ultrathin Polymeric Platform for Drug-Eluting Stent: A proof of concept
title_sort Ultrathin Polymeric Platform for Drug-Eluting Stent: A proof of concept
dc.creator.none.fl_str_mv Bosch Collell, Aniol
Casanova Batlle, Enric
Ausellé i Bosch, Sira
Polonio Alcalá, Emma
Puig i Miquel, Teresa
Ciurana, Quim de
Guerra Sánchez, Antonio
author Bosch Collell, Aniol
author_facet Bosch Collell, Aniol
Casanova Batlle, Enric
Ausellé i Bosch, Sira
Polonio Alcalá, Emma
Puig i Miquel, Teresa
Ciurana, Quim de
Guerra Sánchez, Antonio
author_role author
author2 Casanova Batlle, Enric
Ausellé i Bosch, Sira
Polonio Alcalá, Emma
Puig i Miquel, Teresa
Ciurana, Quim de
Guerra Sánchez, Antonio
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Pròtesis de Stent
Stents (Surgery)
topic Pròtesis de Stent
Stents (Surgery)
description Recent innovations in Drug-Eluting Stents (DES) technology have led to the development of new stents with further reduction in strut width, the ultrathin DES, with struts thinner than 70 µm. Ultrathin DES may further improve the efficacy and safety profile of Percutaneous Coronary Intervention (PCI) by reducing the risk of target-lesion and target-vessel failures compared to the current-generation DES. However, the ultrathin DES metallic platform still presents some associated problems, such as biofilm formation, infection, and migration, all related to the cellular response. The present work aims to produce an ultrathin permanent polymeric platform for a new generation of polymeric drug-eluting stents (PDES). In this work, the cellular response was compared with the traditional stainless steel (SS316L) and polycaprolactone (PCL) to determine whether these polymers could address this challenge. An innovative method of tubular 3D micro stereolithography tubular (ST3DT) was used. Different PDES platforms were fabricated with different polymeric materials (based on polyurethane and urethane dimethacrylate). Subsequently, HFL1 fibroblasts were seeded on the PDES, PCL and SS316L for 3 days. The findings from the assays of cell biocompatibility and proliferation (75%PCL), coupled with the successful fabrication of stent struts below 70 µm using the Surgical Guide resin and the ST3DT method, suggest that resin is a promising candidate for a PDES
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
peer-reviewed
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10256/26168
url http://hdl.handle.net/10256/26168
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.procir.2024.08.042
info:eu-repo/semantics/altIdentifier/issn/2212-8271
dc.rights.none.fl_str_mv Reconeixement-NoComercial-SenseObraDerivada 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Reconeixement-NoComercial-SenseObraDerivada 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 6 p.
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Procedia CIRP, 2024, vol. 125, p. 243-248
Articles publicats (D-EMCI)
Bosch Collell, Aniol Casanova Batlle, Enric Ausellé Bosch, Sira Polonio Alcalá, Emma Puig i Miquel, Teresa Ciurana, Quim de Guerra Sánchez, Antonio 2024 Ultrathin Polymeric Platform for Drug-Eluting Stent: A proof of concept Procedia CIRP 125 243 248
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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