Natural history and surgical outcomes of Rathke’s cleft cysts: a Spanish multicenter study

Rathke's cleft cysts (RCC) are a common type of lesion found in the sellar or suprasellar area. They are usually monitored clinically, but in some cases, surgery may be required. However, their natural progression is not yet well understood, and the outcomes of surgery are uncertain. The object...

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Autores: Menéndez Torre, Edelmiro Luis, Gutiérrez Hurtado, Alba, Ollero, María Dolores, Irigaray, Ana, Martín, Patricia, Parra, Paola, González Molero, Inmaculada, Araujo Castro, Marta, Idrobo, Cindy, Moure, María Dolores, Molina, Ana Rosa, Biagetti, Betina, Iglesias, Pedro, Paja, Miguel, Villar Taibo, Rocío, Pena, Alberto, Vicente, Almudena, Guerrero Pérez, Fernando, Cordido, Fernando, Aulinas, Anna, Mateu, Manel, Soto, Alfonso
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/214891
Acceso en línea:https://hdl.handle.net/2445/214891
Access Level:acceso abierto
Palabra clave:Hipòfisi
Quistos
Pituitary gland
Cysts (Pathology)
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spelling Natural history and surgical outcomes of Rathke’s cleft cysts: a Spanish multicenter studyMenéndez Torre, Edelmiro LuisGutiérrez Hurtado, AlbaOllero, María DoloresIrigaray, AnaMartín, PatriciaParra, PaolaGonzález Molero, InmaculadaAraujo Castro, MartaIdrobo, CindyMoure, María DoloresMolina, Ana RosaBiagetti, BetinaIglesias, PedroPaja, MiguelVillar Taibo, RocíoPena, AlbertoVicente, AlmudenaGuerrero Pérez, FernandoCordido, FernandoAulinas, AnnaMateu, ManelSoto, AlfonsoHipòfisiQuistosPituitary glandCysts (Pathology)Rathke's cleft cysts (RCC) are a common type of lesion found in the sellar or suprasellar area. They are usually monitored clinically, but in some cases, surgery may be required. However, their natural progression is not yet well understood, and the outcomes of surgery are uncertain. The objective of this study is to evaluate the natural history of Rathke's cleft cysts in patients who are clinically monitored without treatment, and to determine the outcomes of surgery and the incidence of recurrences over time.Design and patients National multicentric study of patients diagnosed of Rathke's cleft cyst (RCC- Spain) from 2000 onwards and followed in 15 tertiary centers of Spain. A total of 177 patients diagnosed of RCC followed for 67.3 months (6-215) and 88 patients who underwent surgery, (81 patients underwent immediate surgery after diagnosis and 7 later for subsequent growth) followed for 68.8 months (3-235).Results The cyst size remained stable or decreased in 73.5% (133) of the patients. Only 44 patients (24.3%) experienced a cyst increase and 9 of them (5.1%) experienced an increase greater than 3 mm. In most of the patients who underwent surgery headaches and visual alterations improved, recurrence was observed in 8 (9.1%) after a median time of 96 months, and no predictors of recurrence were discovered.Conclusions Rathke's cleft cysts without initial compressive symptoms have a low probability of growth, so conservative management is recommended. Patients who undergo transsphenoidal surgery experience rapid clinical improvement, and recurrences are infrequent. However, they can occur after a long period of time, although no predictors of recurrence have been identified.Frontiers Media SA2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/214891Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3389/fendo.2024.1413810Frontiers in Endocrinology, 2024, vol. 15https://doi.org/10.3389/fendo.2024.1413810cc by (c) Menéndez Torre, Edelmiro Luis et al, 2024http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2148912026-05-27T06:46:51Z
dc.title.none.fl_str_mv Natural history and surgical outcomes of Rathke’s cleft cysts: a Spanish multicenter study
title Natural history and surgical outcomes of Rathke’s cleft cysts: a Spanish multicenter study
spellingShingle Natural history and surgical outcomes of Rathke’s cleft cysts: a Spanish multicenter study
Menéndez Torre, Edelmiro Luis
Hipòfisi
Quistos
Pituitary gland
Cysts (Pathology)
title_short Natural history and surgical outcomes of Rathke’s cleft cysts: a Spanish multicenter study
title_full Natural history and surgical outcomes of Rathke’s cleft cysts: a Spanish multicenter study
title_fullStr Natural history and surgical outcomes of Rathke’s cleft cysts: a Spanish multicenter study
title_full_unstemmed Natural history and surgical outcomes of Rathke’s cleft cysts: a Spanish multicenter study
title_sort Natural history and surgical outcomes of Rathke’s cleft cysts: a Spanish multicenter study
dc.creator.none.fl_str_mv Menéndez Torre, Edelmiro Luis
Gutiérrez Hurtado, Alba
Ollero, María Dolores
Irigaray, Ana
Martín, Patricia
Parra, Paola
González Molero, Inmaculada
Araujo Castro, Marta
Idrobo, Cindy
Moure, María Dolores
Molina, Ana Rosa
Biagetti, Betina
Iglesias, Pedro
Paja, Miguel
Villar Taibo, Rocío
Pena, Alberto
Vicente, Almudena
Guerrero Pérez, Fernando
Cordido, Fernando
Aulinas, Anna
Mateu, Manel
Soto, Alfonso
author Menéndez Torre, Edelmiro Luis
author_facet Menéndez Torre, Edelmiro Luis
Gutiérrez Hurtado, Alba
Ollero, María Dolores
Irigaray, Ana
Martín, Patricia
Parra, Paola
González Molero, Inmaculada
Araujo Castro, Marta
Idrobo, Cindy
Moure, María Dolores
Molina, Ana Rosa
Biagetti, Betina
Iglesias, Pedro
Paja, Miguel
Villar Taibo, Rocío
Pena, Alberto
Vicente, Almudena
Guerrero Pérez, Fernando
Cordido, Fernando
Aulinas, Anna
Mateu, Manel
Soto, Alfonso
author_role author
author2 Gutiérrez Hurtado, Alba
Ollero, María Dolores
Irigaray, Ana
Martín, Patricia
Parra, Paola
González Molero, Inmaculada
Araujo Castro, Marta
Idrobo, Cindy
Moure, María Dolores
Molina, Ana Rosa
Biagetti, Betina
Iglesias, Pedro
Paja, Miguel
Villar Taibo, Rocío
Pena, Alberto
Vicente, Almudena
Guerrero Pérez, Fernando
Cordido, Fernando
Aulinas, Anna
Mateu, Manel
Soto, Alfonso
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Hipòfisi
Quistos
Pituitary gland
Cysts (Pathology)
topic Hipòfisi
Quistos
Pituitary gland
Cysts (Pathology)
description Rathke's cleft cysts (RCC) are a common type of lesion found in the sellar or suprasellar area. They are usually monitored clinically, but in some cases, surgery may be required. However, their natural progression is not yet well understood, and the outcomes of surgery are uncertain. The objective of this study is to evaluate the natural history of Rathke's cleft cysts in patients who are clinically monitored without treatment, and to determine the outcomes of surgery and the incidence of recurrences over time.Design and patients National multicentric study of patients diagnosed of Rathke's cleft cyst (RCC- Spain) from 2000 onwards and followed in 15 tertiary centers of Spain. A total of 177 patients diagnosed of RCC followed for 67.3 months (6-215) and 88 patients who underwent surgery, (81 patients underwent immediate surgery after diagnosis and 7 later for subsequent growth) followed for 68.8 months (3-235).Results The cyst size remained stable or decreased in 73.5% (133) of the patients. Only 44 patients (24.3%) experienced a cyst increase and 9 of them (5.1%) experienced an increase greater than 3 mm. In most of the patients who underwent surgery headaches and visual alterations improved, recurrence was observed in 8 (9.1%) after a median time of 96 months, and no predictors of recurrence were discovered.Conclusions Rathke's cleft cysts without initial compressive symptoms have a low probability of growth, so conservative management is recommended. Patients who undergo transsphenoidal surgery experience rapid clinical improvement, and recurrences are infrequent. However, they can occur after a long period of time, although no predictors of recurrence have been identified.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/214891
url https://hdl.handle.net/2445/214891
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/fendo.2024.1413810
Frontiers in Endocrinology, 2024, vol. 15
https://doi.org/10.3389/fendo.2024.1413810
dc.rights.none.fl_str_mv cc by (c) Menéndez Torre, Edelmiro Luis et al, 2024
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Menéndez Torre, Edelmiro Luis et al, 2024
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media SA
publisher.none.fl_str_mv Frontiers Media SA
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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