Andrographolide Encapsulation in Metal-Organic Frameworks (MOFs) via Solvent-Free Process at High Pressure

Andrographolide (ADG) encapsulation was carried out on MOFs MIL‐53(Al) and ZIF‐8 by high‐pressure (0.3 GPa) contact. This methodology is not only environment‐friendly but also energy/time‐saving and gives rise to ADG‐MOFs with physical features equivalent to those of materials obtained by common liq...

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Autores: Pantoja-Romero, Wenndy, Aysa-Martínez, Yolanda, Lavín-Flores, Alexis, Medina-Berrios, Nataniel, Bayro, Marvin J., Morell, Gerardo, Weiner, Brad R., Coronas, Joaquín
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Universidad de Zaragoza
Repositorio:Zaguán. Repositorio Digital de la Universidad de Zaragoza
OAI Identifier:oai:zaguan.unizar.es:150140
Acceso en línea:http://zaguan.unizar.es/record/150140
Access Level:acceso abierto
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spelling Andrographolide Encapsulation in Metal-Organic Frameworks (MOFs) via Solvent-Free Process at High PressurePantoja-Romero, WenndyAysa-Martínez, YolandaLavín-Flores, AlexisMedina-Berrios, NatanielBayro, Marvin J.Morell, GerardoWeiner, Brad R.Coronas, JoaquínAndrographolide (ADG) encapsulation was carried out on MOFs MIL‐53(Al) and ZIF‐8 by high‐pressure (0.3 GPa) contact. This methodology is not only environment‐friendly but also energy/time‐saving and gives rise to ADG‐MOFs with physical features equivalent to those of materials obtained by common liquid phase encapsulation. The loaded MOFs were characterized through TEM, SEM, XRD, TGA, FT‐IR, BET, and NMR. The observed decrease in the intensity of ADG XRD peaks is due to the adsorption of ADG into the MOFs. TGA showed the decomposition step of ADG in the range of 200–300 °C in both loaded MOFs. FT‐IR also showed intense signals of the ADG in the synthesized materials. The dissolution profile of ADG in MIL‐53(Al) in PBS (pH=7.4) was carried out showing that the drug was released up to 96 % after 75 h. Solid‐state NMR confirmed the interactions between ADG molecules and ZIF‐8 groups and the formation of a hydrogen bond between the carboxylic group of ADG and the hydroxyl group of MIL‐53(Al). Coefficient partition studies determined that both MOFs did not improve the hydrophilicity of the ADG, due to the loading of the drug preferably occurring by interactions in the hydrophobic areas within the pores of the MOFs.2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://zaguan.unizar.es/record/150140reponame:Zaguán. Repositorio Digital de la Universidad de Zaragozainstname:Universidad de ZaragozaInglésinfo:eu-repo/grantAgreement/ES/DGA/T68-23Rinfo:eu-repo/grantAgreement/ES/MICINN/PID2022-138582OB-I00info:eu-repo/semantics/openAccessoai:zaguan.unizar.es:1501402026-05-29T13:59:51Z
dc.title.none.fl_str_mv Andrographolide Encapsulation in Metal-Organic Frameworks (MOFs) via Solvent-Free Process at High Pressure
title Andrographolide Encapsulation in Metal-Organic Frameworks (MOFs) via Solvent-Free Process at High Pressure
spellingShingle Andrographolide Encapsulation in Metal-Organic Frameworks (MOFs) via Solvent-Free Process at High Pressure
Pantoja-Romero, Wenndy
title_short Andrographolide Encapsulation in Metal-Organic Frameworks (MOFs) via Solvent-Free Process at High Pressure
title_full Andrographolide Encapsulation in Metal-Organic Frameworks (MOFs) via Solvent-Free Process at High Pressure
title_fullStr Andrographolide Encapsulation in Metal-Organic Frameworks (MOFs) via Solvent-Free Process at High Pressure
title_full_unstemmed Andrographolide Encapsulation in Metal-Organic Frameworks (MOFs) via Solvent-Free Process at High Pressure
title_sort Andrographolide Encapsulation in Metal-Organic Frameworks (MOFs) via Solvent-Free Process at High Pressure
dc.creator.none.fl_str_mv Pantoja-Romero, Wenndy
Aysa-Martínez, Yolanda
Lavín-Flores, Alexis
Medina-Berrios, Nataniel
Bayro, Marvin J.
Morell, Gerardo
Weiner, Brad R.
Coronas, Joaquín
author Pantoja-Romero, Wenndy
author_facet Pantoja-Romero, Wenndy
Aysa-Martínez, Yolanda
Lavín-Flores, Alexis
Medina-Berrios, Nataniel
Bayro, Marvin J.
Morell, Gerardo
Weiner, Brad R.
Coronas, Joaquín
author_role author
author2 Aysa-Martínez, Yolanda
Lavín-Flores, Alexis
Medina-Berrios, Nataniel
Bayro, Marvin J.
Morell, Gerardo
Weiner, Brad R.
Coronas, Joaquín
author2_role author
author
author
author
author
author
author
description Andrographolide (ADG) encapsulation was carried out on MOFs MIL‐53(Al) and ZIF‐8 by high‐pressure (0.3 GPa) contact. This methodology is not only environment‐friendly but also energy/time‐saving and gives rise to ADG‐MOFs with physical features equivalent to those of materials obtained by common liquid phase encapsulation. The loaded MOFs were characterized through TEM, SEM, XRD, TGA, FT‐IR, BET, and NMR. The observed decrease in the intensity of ADG XRD peaks is due to the adsorption of ADG into the MOFs. TGA showed the decomposition step of ADG in the range of 200–300 °C in both loaded MOFs. FT‐IR also showed intense signals of the ADG in the synthesized materials. The dissolution profile of ADG in MIL‐53(Al) in PBS (pH=7.4) was carried out showing that the drug was released up to 96 % after 75 h. Solid‐state NMR confirmed the interactions between ADG molecules and ZIF‐8 groups and the formation of a hydrogen bond between the carboxylic group of ADG and the hydroxyl group of MIL‐53(Al). Coefficient partition studies determined that both MOFs did not improve the hydrophilicity of the ADG, due to the loading of the drug preferably occurring by interactions in the hydrophobic areas within the pores of the MOFs.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.none.fl_str_mv http://zaguan.unizar.es/record/150140
url http://zaguan.unizar.es/record/150140
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/ES/DGA/T68-23R
info:eu-repo/grantAgreement/ES/MICINN/PID2022-138582OB-I00
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv
publisher.none.fl_str_mv
dc.source.none.fl_str_mv reponame:Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname:Universidad de Zaragoza
instname_str Universidad de Zaragoza
reponame_str Zaguán. Repositorio Digital de la Universidad de Zaragoza
collection Zaguán. Repositorio Digital de la Universidad de Zaragoza
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