Influence of Obstructive Sleep Apnea on Maternal and Perinatal Outcomes in Patients With Gestational Diabetes Mellitus

The prevalence of obstructive sleep apnea (OSA) increases during pregnancy and is associated with gestational diabetes mellitus (GDM), although its clinical impact on birth outcomes remains unclear. We aimed to assess the effect of several OSA criteria and intermittent hypoxia in the third trimester...

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Authors: Cerda Moncadas, Maria, Serednytskyy, Oleksandr, De Larrinaga, Ainhoa Álvarez Ruiz, Cànaves-Gómez, Laura, Barón, Andrés Sánchez, Marcet, Mercedes Codina, de la Peña-Bravo, Mónica, Iglesias, Amanda, Morell-Garcia, Daniel, Peña-Zarza, José Antonio, Gimenez Carrero, María Paloma, Piñas Cebrian, Maria Concepcion, García Fernández, Susana, García-Río, Francisco, Alonso Fernández, Alberto
Format: article
Publication Date:2025
Country:España
Institution:Conselleria de Salut i Consum del Govern de les Illes Balears
Repository:Docusalut
Language:English
OAI Identifier:oai:docusalut.com:20.500.13003/25972
Online Access:https://hdl.handle.net/20.500.13003/25972
Access Level:Open access
Keyword:Diabetes, Gestational
Sleep Apnea, Obstructive
Diabetes Gestacional
Apnea Obstructiva del Sueño
apnea–hypopnea index
fetal outcomes
gestational diabetes mellitus
maternal–fetal health
obstructive sleep apnea
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spelling Influence of Obstructive Sleep Apnea on Maternal and Perinatal Outcomes in Patients With Gestational Diabetes MellitusCerda Moncadas, MariaSerednytskyy, OleksandrDe Larrinaga, Ainhoa Álvarez RuizCànaves-Gómez, LauraBarón, Andrés SánchezMarcet, Mercedes Codinade la Peña-Bravo, MónicaIglesias, AmandaMorell-Garcia, DanielPeña-Zarza, José AntonioGimenez Carrero, María PalomaPiñas Cebrian, Maria ConcepcionGarcía Fernández, SusanaGarcía-Río, FranciscoAlonso Fernández, AlbertoDiabetes, GestationalSleep Apnea, ObstructiveDiabetes GestacionalApnea Obstructiva del Sueñoapnea–hypopnea indexfetal outcomesgestational diabetes mellitusmaternal–fetal healthobstructive sleep apneaThe prevalence of obstructive sleep apnea (OSA) increases during pregnancy and is associated with gestational diabetes mellitus (GDM), although its clinical impact on birth outcomes remains unclear. We aimed to assess the effect of several OSA criteria and intermittent hypoxia in the third trimester on perinatal outcomes in women with GDM. In this prospective study, polysomnography was performed on 89 women with GDM. Insulin resistance indices (HOMA-IR/QUICKI) were calculated, and biomarkers (insulin-like growth factor-1 (IGF-1), resistin, soluble endoglobulin, galectin-3, and free fatty acids) were analysed from women and some cord blood samples using enzyme-linked immunosorbent assay. Whereas OSA did not significantly affect overall perinatal outcomes, specific OSA features-including REM-OSA, supine-position OSA, and an oxygen desaturation index (ODI) ≥ 1 h-were linked to adverse effects on neonatal birthweight and length. Moreover, apnea duration was an independent predictor of birthweight, while insulin resistance was more impaired in women with OSA and showed an inverse relationship with sleep and REM time, respectively. IGF-1 was elevated and demonstrated a significant predictive value for OSA, as indicated by the AUC-ROC curve. In summary, although OSA did not adversely affect overall perinatal outcomes in women with GDM, specific OSA characteristics were associated with adverse neonatal growth metrics. Insulin resistance was higher in women with OSA, and IGF-1 may serve as a potential biomarker for OSA in this population. Further prospective studies with attention to REM-stage, supine-position OSA, apnea duration, and hypoxic burden are needed to elucidate the complex interactions between OSA, GDM, and fetal outcomes.Wiley20252025-09-1820252025-09-18research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.13003/25972reponame:Docusalutinstname:Conselleria de Salut i Consum del Govern de les Illes BalearsInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:docusalut.com:20.500.13003/259722026-06-22T12:44:07Z
dc.title.none.fl_str_mv Influence of Obstructive Sleep Apnea on Maternal and Perinatal Outcomes in Patients With Gestational Diabetes Mellitus
title Influence of Obstructive Sleep Apnea on Maternal and Perinatal Outcomes in Patients With Gestational Diabetes Mellitus
spellingShingle Influence of Obstructive Sleep Apnea on Maternal and Perinatal Outcomes in Patients With Gestational Diabetes Mellitus
Cerda Moncadas, Maria
Diabetes, Gestational
Sleep Apnea, Obstructive
Diabetes Gestacional
Apnea Obstructiva del Sueño
apnea–hypopnea index
fetal outcomes
gestational diabetes mellitus
maternal–fetal health
obstructive sleep apnea
title_short Influence of Obstructive Sleep Apnea on Maternal and Perinatal Outcomes in Patients With Gestational Diabetes Mellitus
title_full Influence of Obstructive Sleep Apnea on Maternal and Perinatal Outcomes in Patients With Gestational Diabetes Mellitus
title_fullStr Influence of Obstructive Sleep Apnea on Maternal and Perinatal Outcomes in Patients With Gestational Diabetes Mellitus
title_full_unstemmed Influence of Obstructive Sleep Apnea on Maternal and Perinatal Outcomes in Patients With Gestational Diabetes Mellitus
title_sort Influence of Obstructive Sleep Apnea on Maternal and Perinatal Outcomes in Patients With Gestational Diabetes Mellitus
dc.creator.none.fl_str_mv Cerda Moncadas, Maria
Serednytskyy, Oleksandr
De Larrinaga, Ainhoa Álvarez Ruiz
Cànaves-Gómez, Laura
Barón, Andrés Sánchez
Marcet, Mercedes Codina
de la Peña-Bravo, Mónica
Iglesias, Amanda
Morell-Garcia, Daniel
Peña-Zarza, José Antonio
Gimenez Carrero, María Paloma
Piñas Cebrian, Maria Concepcion
García Fernández, Susana
García-Río, Francisco
Alonso Fernández, Alberto
author Cerda Moncadas, Maria
author_facet Cerda Moncadas, Maria
Serednytskyy, Oleksandr
De Larrinaga, Ainhoa Álvarez Ruiz
Cànaves-Gómez, Laura
Barón, Andrés Sánchez
Marcet, Mercedes Codina
de la Peña-Bravo, Mónica
Iglesias, Amanda
Morell-Garcia, Daniel
Peña-Zarza, José Antonio
Gimenez Carrero, María Paloma
Piñas Cebrian, Maria Concepcion
García Fernández, Susana
García-Río, Francisco
Alonso Fernández, Alberto
author_role author
author2 Serednytskyy, Oleksandr
De Larrinaga, Ainhoa Álvarez Ruiz
Cànaves-Gómez, Laura
Barón, Andrés Sánchez
Marcet, Mercedes Codina
de la Peña-Bravo, Mónica
Iglesias, Amanda
Morell-Garcia, Daniel
Peña-Zarza, José Antonio
Gimenez Carrero, María Paloma
Piñas Cebrian, Maria Concepcion
García Fernández, Susana
García-Río, Francisco
Alonso Fernández, Alberto
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Diabetes, Gestational
Sleep Apnea, Obstructive
Diabetes Gestacional
Apnea Obstructiva del Sueño
apnea–hypopnea index
fetal outcomes
gestational diabetes mellitus
maternal–fetal health
obstructive sleep apnea
topic Diabetes, Gestational
Sleep Apnea, Obstructive
Diabetes Gestacional
Apnea Obstructiva del Sueño
apnea–hypopnea index
fetal outcomes
gestational diabetes mellitus
maternal–fetal health
obstructive sleep apnea
description The prevalence of obstructive sleep apnea (OSA) increases during pregnancy and is associated with gestational diabetes mellitus (GDM), although its clinical impact on birth outcomes remains unclear. We aimed to assess the effect of several OSA criteria and intermittent hypoxia in the third trimester on perinatal outcomes in women with GDM. In this prospective study, polysomnography was performed on 89 women with GDM. Insulin resistance indices (HOMA-IR/QUICKI) were calculated, and biomarkers (insulin-like growth factor-1 (IGF-1), resistin, soluble endoglobulin, galectin-3, and free fatty acids) were analysed from women and some cord blood samples using enzyme-linked immunosorbent assay. Whereas OSA did not significantly affect overall perinatal outcomes, specific OSA features-including REM-OSA, supine-position OSA, and an oxygen desaturation index (ODI) ≥ 1 h-were linked to adverse effects on neonatal birthweight and length. Moreover, apnea duration was an independent predictor of birthweight, while insulin resistance was more impaired in women with OSA and showed an inverse relationship with sleep and REM time, respectively. IGF-1 was elevated and demonstrated a significant predictive value for OSA, as indicated by the AUC-ROC curve. In summary, although OSA did not adversely affect overall perinatal outcomes in women with GDM, specific OSA characteristics were associated with adverse neonatal growth metrics. Insulin resistance was higher in women with OSA, and IGF-1 may serve as a potential biomarker for OSA in this population. Further prospective studies with attention to REM-stage, supine-position OSA, apnea duration, and hypoxic burden are needed to elucidate the complex interactions between OSA, GDM, and fetal outcomes.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-09-18
2025
2025-09-18
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.13003/25972
url https://hdl.handle.net/20.500.13003/25972
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Docusalut
instname:Conselleria de Salut i Consum del Govern de les Illes Balears
instname_str Conselleria de Salut i Consum del Govern de les Illes Balears
reponame_str Docusalut
collection Docusalut
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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