Midbrain and pons MRI shape analysis and its clinical and CSF correlates in degenerative parkinsonisms: a pilot study.

Objectives: To conduct brainstem MRI shape analysis across neurodegenerative parkinsonisms and control subjects (CS), along with its association with clinical and cerebrospinal fluid (CSF) correlates. Methodology: We collected demographic and clinical variables, performed planimetric and shape MRI a...

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Detalhes bibliográficos
Autores: Painous Martí, Cèlia, Pascual-Diaz, Saül, Muñoz-Moreno, Emma, Sánchez, V., Pariente, Jose Carlos, Prats Galino, Alberto, Soto Gimeno, Marta, Fernández, Manel, Pérez Soriano, Alexandra, Cámara, Ana, Muñoz, Esteban, Valldeoriola Serra, Francesc, Caballol, Núria, Pont Sunyer, Claustre, Martín Flores, Núria, Basora Macaya, Misericordia, Tió, Montserrat, Ríos, José, Martí Domènech, Ma. Josep, Bargalló Alabart, Núria, Compta, Yaroslau
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/220580
Acesso em linha:https://hdl.handle.net/2445/220580
Access Level:acceso abierto
Palavra-chave:Ressonància magnètica
Degeneració (Patologia)
Malaltia de Parkinson
Tronc de l'encèfal
Forma
Magnetic resonance
Degeneration (Pathology)
Parkinson's disease
Brain stem
Shape
Descrição
Resumo:Objectives: To conduct brainstem MRI shape analysis across neurodegenerative parkinsonisms and control subjects (CS), along with its association with clinical and cerebrospinal fluid (CSF) correlates. Methodology: We collected demographic and clinical variables, performed planimetric and shape MRI analyses, and determined CSF neurofilament-light chain (NfL) levels in 84 participants: 11 CS, 12 with Parkinson's disease (PD), 26 with multiple system atrophy (MSA), 21 with progressive supranuclear palsy (PSP), and 14 with corticobasal degeneration (CBD). Results: MSA featured the most extensive and significant brainstem shape narrowing (that is, atrophy), mostly in the pons. CBD presented local atrophy in several small areas in the pons and midbrain compared to PD and CS. PSP presented local atrophy in small areas in the posterior and upper midbrain as well as the rostral pons compared to MSA. Our findings of planimetric MRI measurements and CSF NfL levels replicated those from previous literature. Brainstem shape atrophy correlated with worse motor state in all parkinsonisms and with higher NfL levels in MSA, PSP, and PD. Conclusion: Atypical parkinsonisms present different brainstem shape patterns which correlate with clinical severity and neuronal degeneration. In MSA, shape analysis could be further explored as a potential diagnostic biomarker. By contrast, shape analysis appears to have a rather limited discriminant value in PSP. Key points: • Atypical parkinsonisms present different brainstem shape patterns. • Shape patterns correlate with clinical severity and neuronal degeneration. • In MSA, shape analysis could be further explored as a potential diagnostic biomarker.

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