Long-term liver stiffness dynamics after sustained virological response in patients with HIV/HCV co-infection and advanced fibrosis

Objective: This study analyses liver stiffness (LS) dynamics in people with HIV (PWH) and advanced liver fibrosis who achieved sustained virological response (SVR) and assess factors associated with LS normalization or progression, after long-term follow-up.Design:Prospective multicenter cohort stud...

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Autores: Martín Carmona, Jésica, Corona Mata, Diana, Téllez, Francisco, Navarrete Lorite, Miguel Nicolás, Barroso, Isabel, Carlos Alados, Juan, Palacios Muñoz, Rosario, Santos, Ignacio de los, Vera Méndez, Francisco Jesús, Imaz, Arkaitz, Raffo Márquez, Miguel, Morano Vázquez, Aitana Carla, José Galindo, María, Belinchón, Olga, Serrano Fuentes, Miriam, López Zúñiga, Miguel Ángel, Galera Peñaranda, Carlos, Reus Bañuls, Sergio Javier, Pineda, Juan A., Macías, Juan, Corma Gómez, Anaïs, Gehep-011 Study Group
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:dnet:recercat____::27ee5fc2aad68c05eb87f90841149302
Acceso en línea:https://hdl.handle.net/2445/228761
Access Level:acceso abierto
Palabra clave:Infeccions per VIH
Hepatitis C
Malalties del fetge
HIV infections
Liver diseases
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spelling Long-term liver stiffness dynamics after sustained virological response in patients with HIV/HCV co-infection and advanced fibrosisMartín Carmona, JésicaCorona Mata, DianaTéllez, FranciscoNavarrete Lorite, Miguel NicolásBarroso, IsabelCarlos Alados, JuanPalacios Muñoz, RosarioSantos, Ignacio de losVera Méndez, Francisco JesúsImaz, ArkaitzRaffo Márquez, MiguelMorano Vázquez, Aitana CarlaJosé Galindo, MaríaBelinchón, OlgaSerrano Fuentes, MiriamLópez Zúñiga, Miguel ÁngelGalera Peñaranda, CarlosReus Bañuls, Sergio JavierPineda, Juan A.Macías, JuanCorma Gómez, AnaïsGehep-011 Study GroupInfeccions per VIHHepatitis CMalalties del fetgeHIV infectionsHepatitis CLiver diseasesObjective: This study analyses liver stiffness (LS) dynamics in people with HIV (PWH) and advanced liver fibrosis who achieved sustained virological response (SVR) and assess factors associated with LS normalization or progression, after long-term follow-up.Design:Prospective multicenter cohort study. Methods: This study included individuals with HIV/HCV co-infection from the Spanish GEHEP-011 cohort, fulfilling: pretreatment LS >= 9.5 kPa; sustained virological response (SVR) with direct-acting antiviral regimen; available measurement of LS at SVR. Factors associated with LS normalization (achieving <= 7.2 kPa in two consecutive measurement) and progression (increase of >20% LS at the last measurement available) were analyzed. Results: A total of 678 patients were included. The median follow-up was 40 (17-71) months. The repeated measures ANOVA revealed a significant main effect of time on LS. Overall, 221 (32.6%) achieved normalization. Lower probability of normalization was associated with advanced liver disease [baseline LS: sHR = 0.26 (95% CI, 0.19-0.37), P < 0.001; liver decompensation before SVR: sHR = 0.22 (0.05-0.97), P < 0.001; baseline MELD score: sHR = 0.81 (0.69-0.94), P = 0.006]. LS progression occurred in 50 (7.4%). Progression was associated with higher baseline LS [sHR = 1.04 (1.01-1.07), P = 0.007], controlled attenuation parameter (CAP) [CAP >= 280 dB/m: sHR = 2.94 (1.16-7.44)] and older age [sHR 1.06 (1.00-1.13), per year, P = 0.04]. Conclusions: In PWH, LS significantly decreases after HCV cure in the long-term, achieving values of <= 7.2 kPa. In a substantial proportion of patients, LS remain stable or even increases. Older age and concomitant steatotic liver disease are associated with LS progression.Ovid Technologies (Wolters Kluwer Health)2026202620252026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion9 p.application/pdfhttps://hdl.handle.net/2445/228761Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1097/QAD.0000000000004357AIDS, 2025, vol. 40, num. 2, p. 151-159https://doi.org/10.1097/QAD.0000000000004357cc-by-nc-nd (c) Martín Carmona, Jésica et al., 2025https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:dnet:recercat____::27ee5fc2aad68c05eb87f908411493022026-05-29T05:05:01Z
dc.title.none.fl_str_mv Long-term liver stiffness dynamics after sustained virological response in patients with HIV/HCV co-infection and advanced fibrosis
title Long-term liver stiffness dynamics after sustained virological response in patients with HIV/HCV co-infection and advanced fibrosis
spellingShingle Long-term liver stiffness dynamics after sustained virological response in patients with HIV/HCV co-infection and advanced fibrosis
Martín Carmona, Jésica
Infeccions per VIH
Hepatitis C
Malalties del fetge
HIV infections
Hepatitis C
Liver diseases
title_short Long-term liver stiffness dynamics after sustained virological response in patients with HIV/HCV co-infection and advanced fibrosis
title_full Long-term liver stiffness dynamics after sustained virological response in patients with HIV/HCV co-infection and advanced fibrosis
title_fullStr Long-term liver stiffness dynamics after sustained virological response in patients with HIV/HCV co-infection and advanced fibrosis
title_full_unstemmed Long-term liver stiffness dynamics after sustained virological response in patients with HIV/HCV co-infection and advanced fibrosis
title_sort Long-term liver stiffness dynamics after sustained virological response in patients with HIV/HCV co-infection and advanced fibrosis
dc.creator.none.fl_str_mv Martín Carmona, Jésica
Corona Mata, Diana
Téllez, Francisco
Navarrete Lorite, Miguel Nicolás
Barroso, Isabel
Carlos Alados, Juan
Palacios Muñoz, Rosario
Santos, Ignacio de los
Vera Méndez, Francisco Jesús
Imaz, Arkaitz
Raffo Márquez, Miguel
Morano Vázquez, Aitana Carla
José Galindo, María
Belinchón, Olga
Serrano Fuentes, Miriam
López Zúñiga, Miguel Ángel
Galera Peñaranda, Carlos
Reus Bañuls, Sergio Javier
Pineda, Juan A.
Macías, Juan
Corma Gómez, Anaïs
Gehep-011 Study Group
author Martín Carmona, Jésica
author_facet Martín Carmona, Jésica
Corona Mata, Diana
Téllez, Francisco
Navarrete Lorite, Miguel Nicolás
Barroso, Isabel
Carlos Alados, Juan
Palacios Muñoz, Rosario
Santos, Ignacio de los
Vera Méndez, Francisco Jesús
Imaz, Arkaitz
Raffo Márquez, Miguel
Morano Vázquez, Aitana Carla
José Galindo, María
Belinchón, Olga
Serrano Fuentes, Miriam
López Zúñiga, Miguel Ángel
Galera Peñaranda, Carlos
Reus Bañuls, Sergio Javier
Pineda, Juan A.
Macías, Juan
Corma Gómez, Anaïs
Gehep-011 Study Group
author_role author
author2 Corona Mata, Diana
Téllez, Francisco
Navarrete Lorite, Miguel Nicolás
Barroso, Isabel
Carlos Alados, Juan
Palacios Muñoz, Rosario
Santos, Ignacio de los
Vera Méndez, Francisco Jesús
Imaz, Arkaitz
Raffo Márquez, Miguel
Morano Vázquez, Aitana Carla
José Galindo, María
Belinchón, Olga
Serrano Fuentes, Miriam
López Zúñiga, Miguel Ángel
Galera Peñaranda, Carlos
Reus Bañuls, Sergio Javier
Pineda, Juan A.
Macías, Juan
Corma Gómez, Anaïs
Gehep-011 Study Group
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Infeccions per VIH
Hepatitis C
Malalties del fetge
HIV infections
Hepatitis C
Liver diseases
topic Infeccions per VIH
Hepatitis C
Malalties del fetge
HIV infections
Hepatitis C
Liver diseases
description Objective: This study analyses liver stiffness (LS) dynamics in people with HIV (PWH) and advanced liver fibrosis who achieved sustained virological response (SVR) and assess factors associated with LS normalization or progression, after long-term follow-up.Design:Prospective multicenter cohort study. Methods: This study included individuals with HIV/HCV co-infection from the Spanish GEHEP-011 cohort, fulfilling: pretreatment LS >= 9.5 kPa; sustained virological response (SVR) with direct-acting antiviral regimen; available measurement of LS at SVR. Factors associated with LS normalization (achieving <= 7.2 kPa in two consecutive measurement) and progression (increase of >20% LS at the last measurement available) were analyzed. Results: A total of 678 patients were included. The median follow-up was 40 (17-71) months. The repeated measures ANOVA revealed a significant main effect of time on LS. Overall, 221 (32.6%) achieved normalization. Lower probability of normalization was associated with advanced liver disease [baseline LS: sHR = 0.26 (95% CI, 0.19-0.37), P < 0.001; liver decompensation before SVR: sHR = 0.22 (0.05-0.97), P < 0.001; baseline MELD score: sHR = 0.81 (0.69-0.94), P = 0.006]. LS progression occurred in 50 (7.4%). Progression was associated with higher baseline LS [sHR = 1.04 (1.01-1.07), P = 0.007], controlled attenuation parameter (CAP) [CAP >= 280 dB/m: sHR = 2.94 (1.16-7.44)] and older age [sHR 1.06 (1.00-1.13), per year, P = 0.04]. Conclusions: In PWH, LS significantly decreases after HCV cure in the long-term, achieving values of <= 7.2 kPa. In a substantial proportion of patients, LS remain stable or even increases. Older age and concomitant steatotic liver disease are associated with LS progression.
publishDate 2025
dc.date.none.fl_str_mv 2025
2026
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/228761
url https://hdl.handle.net/2445/228761
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1097/QAD.0000000000004357
AIDS, 2025, vol. 40, num. 2, p. 151-159
https://doi.org/10.1097/QAD.0000000000004357
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Martín Carmona, Jésica et al., 2025
https://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Martín Carmona, Jésica et al., 2025
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 9 p.
application/pdf
dc.publisher.none.fl_str_mv Ovid Technologies (Wolters Kluwer Health)
publisher.none.fl_str_mv Ovid Technologies (Wolters Kluwer Health)
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869423018188472320
score 15.81155

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