Enriched mesoporous bioactive glass scaffolds as bone substitutes in critical diaphyseal bone defects in rabbits

In the field of orthopedic surgery, there is an increasing need for the development of bone replacement materials for the treatment of bone defects. One of the main focuses of biomaterials engineering are ad- vanced bioceramics like mesoporous bioactive glasses (MBG´s). The present study compared th...

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Authors: García Lamas, Lorena, Lozano Borregón, Daniel, Jiménez Díaz, Verónica, Bravo Giménez, Beatriz, Sánchez Salcedo, Sandra, Abella García, Mónica, Desco, Manuel, Jiménez Holguín, Javier, Vallet Regí, María Dulce Nombre, Cecilia López, David, Salinas Sánchez, Antonio Jesús
Format: article
Publication Date:2024
Country:España
Institution:Universidad Complutense de Madrid (UCM)
Repository:Docta Complutense
Language:English
OAI Identifier:oai:docta.ucm.es:20.500.14352/104518
Online Access:https://hdl.handle.net/20.500.14352/104518
Access Level:Open access
Keyword:615:54
615.31
Bone substitutes
Osteostatin
Mesoporous bioactive glasses
Bone regeneration
Rabbi
Química farmaceútica
23 Química
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oai_identifier_str oai:docta.ucm.es:20.500.14352/104518
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spelling Enriched mesoporous bioactive glass scaffolds as bone substitutes in critical diaphyseal bone defects in rabbitsGarcía Lamas, LorenaLozano Borregón, DanielJiménez Díaz, VerónicaBravo Giménez, BeatrizSánchez Salcedo, SandraAbella García, MónicaDesco, ManuelJiménez Holguín, JavierVallet Regí, María Dulce NombreCecilia López, DavidSalinas Sánchez, Antonio Jesús615:54615.31Bone substitutesOsteostatinMesoporous bioactive glassesBone regenerationRabbiQuímica farmaceútica23 QuímicaIn the field of orthopedic surgery, there is an increasing need for the development of bone replacement materials for the treatment of bone defects. One of the main focuses of biomaterials engineering are ad- vanced bioceramics like mesoporous bioactive glasses (MBG´s). The present study compared the new bone formation after 12 weeks of implantation of MBG scaffolds with composition 82,5SiO2 –10CaO–5P2 O5 - x 2.5SrO alone (MBGA), enriched with osteostatin, an osteoinductive peptide, (MBGO) or enriched with bone marrow aspirate (MBGB) in a long bone critical defect in radius bone of adult New Zealand rab- bits. New bone formation from the MBG scaffold groups was compared to the gold standard defect filled with iliac crest autograft and to the unfilled defect. Radiographic follow-up was performed at 2, 6, and 12 weeks, and microCT and histologic examination were performed at 12 weeks. X-Ray study showed the highest bone formation scores in the group with the defect filled with autograft, followed by the MBGB group, in addition, the microCT study showed that bone within defect scores (BV/TV) were higher in the MBGO group. This difference could be explained by the higher density of newly formed bone in the os- teostatin enriched MBG scaffold group. Therefore, MBG scaffold alone and enriched with osteostatin or bone marrow aspirate increase bone formation compared to defect unfilled, being higher in the osteo- statin group. The present results showed the potential to treat critical bone defects by combining MBGs with osteogenic peptides such as osteostatin, with good prospects for translation into clinical practice.Universidad Complutense de Madrid20242024-05-1220242024-05-12journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/104518reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)InglésengInstituto de Salud Carlos III http://dx.doi.org/10.13039/501100004587 Not available PI20MCIN AEI PDC2021-121656-I00 00121open accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1045182026-06-02T12:44:21Z
dc.title.none.fl_str_mv Enriched mesoporous bioactive glass scaffolds as bone substitutes in critical diaphyseal bone defects in rabbits
title Enriched mesoporous bioactive glass scaffolds as bone substitutes in critical diaphyseal bone defects in rabbits
spellingShingle Enriched mesoporous bioactive glass scaffolds as bone substitutes in critical diaphyseal bone defects in rabbits
García Lamas, Lorena
615:54
615.31
Bone substitutes
Osteostatin
Mesoporous bioactive glasses
Bone regeneration
Rabbi
Química farmaceútica
23 Química
title_short Enriched mesoporous bioactive glass scaffolds as bone substitutes in critical diaphyseal bone defects in rabbits
title_full Enriched mesoporous bioactive glass scaffolds as bone substitutes in critical diaphyseal bone defects in rabbits
title_fullStr Enriched mesoporous bioactive glass scaffolds as bone substitutes in critical diaphyseal bone defects in rabbits
title_full_unstemmed Enriched mesoporous bioactive glass scaffolds as bone substitutes in critical diaphyseal bone defects in rabbits
title_sort Enriched mesoporous bioactive glass scaffolds as bone substitutes in critical diaphyseal bone defects in rabbits
dc.creator.none.fl_str_mv García Lamas, Lorena
Lozano Borregón, Daniel
Jiménez Díaz, Verónica
Bravo Giménez, Beatriz
Sánchez Salcedo, Sandra
Abella García, Mónica
Desco, Manuel
Jiménez Holguín, Javier
Vallet Regí, María Dulce Nombre
Cecilia López, David
Salinas Sánchez, Antonio Jesús
author García Lamas, Lorena
author_facet García Lamas, Lorena
Lozano Borregón, Daniel
Jiménez Díaz, Verónica
Bravo Giménez, Beatriz
Sánchez Salcedo, Sandra
Abella García, Mónica
Desco, Manuel
Jiménez Holguín, Javier
Vallet Regí, María Dulce Nombre
Cecilia López, David
Salinas Sánchez, Antonio Jesús
author_role author
author2 Lozano Borregón, Daniel
Jiménez Díaz, Verónica
Bravo Giménez, Beatriz
Sánchez Salcedo, Sandra
Abella García, Mónica
Desco, Manuel
Jiménez Holguín, Javier
Vallet Regí, María Dulce Nombre
Cecilia López, David
Salinas Sánchez, Antonio Jesús
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 615:54
615.31
Bone substitutes
Osteostatin
Mesoporous bioactive glasses
Bone regeneration
Rabbi
Química farmaceútica
23 Química
topic 615:54
615.31
Bone substitutes
Osteostatin
Mesoporous bioactive glasses
Bone regeneration
Rabbi
Química farmaceútica
23 Química
description In the field of orthopedic surgery, there is an increasing need for the development of bone replacement materials for the treatment of bone defects. One of the main focuses of biomaterials engineering are ad- vanced bioceramics like mesoporous bioactive glasses (MBG´s). The present study compared the new bone formation after 12 weeks of implantation of MBG scaffolds with composition 82,5SiO2 –10CaO–5P2 O5 - x 2.5SrO alone (MBGA), enriched with osteostatin, an osteoinductive peptide, (MBGO) or enriched with bone marrow aspirate (MBGB) in a long bone critical defect in radius bone of adult New Zealand rab- bits. New bone formation from the MBG scaffold groups was compared to the gold standard defect filled with iliac crest autograft and to the unfilled defect. Radiographic follow-up was performed at 2, 6, and 12 weeks, and microCT and histologic examination were performed at 12 weeks. X-Ray study showed the highest bone formation scores in the group with the defect filled with autograft, followed by the MBGB group, in addition, the microCT study showed that bone within defect scores (BV/TV) were higher in the MBGO group. This difference could be explained by the higher density of newly formed bone in the os- teostatin enriched MBG scaffold group. Therefore, MBG scaffold alone and enriched with osteostatin or bone marrow aspirate increase bone formation compared to defect unfilled, being higher in the osteo- statin group. The present results showed the potential to treat critical bone defects by combining MBGs with osteogenic peptides such as osteostatin, with good prospects for translation into clinical practice.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-05-12
2024
2024-05-12
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/104518
url https://hdl.handle.net/20.500.14352/104518
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Instituto de Salud Carlos III http://dx.doi.org/10.13039/501100004587 Not available PI20
MCIN AEI PDC2021-121656-I00 00121
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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