Cubic Liquid Crystalline Structures in diluted, concentrated and highly concentrated emulsions for topical application: influence on drug release and human skin permeation

Novel emulsions with a nanostructured continuous phase have been proposed as controlled drug delivery systems to enhance topical delivery of active ingredients avoiding systemic effects. In this study, oil-in-water (O/W) emulsions with two surfactant/water (S/W) weight ratios of 40:60 and 35:65, and...

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Autores: Arias Chousa, Eva María, Guiró, Pere, Rodríguez-Abreu, Carlos, Solans Marsà, Conxita, Escribano Ferrer, Elvira, García Celma, Ma José
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2019
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/179009
Acceso en línea:https://hdl.handle.net/2445/179009
Access Level:acceso abierto
Palabra clave:Emulsions (Farmàcia)
Desenvolupament de medicaments
Absorció cutània
Pell
Emulsions (Pharmacy)
Drug development
Skin absorption
Skin
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spelling Cubic Liquid Crystalline Structures in diluted, concentrated and highly concentrated emulsions for topical application: influence on drug release and human skin permeationArias Chousa, Eva MaríaGuiró, PereRodríguez-Abreu, CarlosSolans Marsà, ConxitaEscribano Ferrer, ElviraGarcía Celma, Ma JoséEmulsions (Farmàcia)Desenvolupament de medicamentsAbsorció cutàniaPellEmulsions (Pharmacy)Drug developmentSkin absorptionSkinNovel emulsions with a nanostructured continuous phase have been proposed as controlled drug delivery systems to enhance topical delivery of active ingredients avoiding systemic effects. In this study, oil-in-water (O/W) emulsions with two surfactant/water (S/W) weight ratios of 40:60 and 35:65, and oil concentrations of 10 wt% (diluted emulsion), 40 wt% (concentrated emulsion) and 85 wt% (highly concentrated emulsion) have been investigated to identify the presence of liquid crystalline structures and their influence on drug release and skin permeation. The emulsions have been characterized in terms of visual appearance, rheology and drug release. The presence of cubic liquid crystalline structures in emulsions with S/W 40:60 was confirmed by small angle X-ray scattering (SAXS). Rheology results showed a markedly different behaviour in emulsions with S/W 40:60 compared with nonstructured emulsions. A model drug, diclofenac sodium (DS) was successfully incorporated in the emulsions. DS release was studied with hydrophilic and lipophilic membranes, and the amount of DS in the receptor solution was significantly lower in the formulations containing cubic liquid structures. An in vitro skin permeation study with dermatomed human skin showed that emulsions with a nanostructured continuous phase are suitable formulations for topical delivery with DS retention in skin layers. The results indicate that the amount of drug retained in skin structures may be tuned by modification of liquid crystal concentration and emulsion structure.Elsevier B.V.2021202120192021info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion9 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/179009Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1016/j.ijpharm.2019.118531International Journal of Pharmaceutics, 2019, vol. 569, p. 1-9https://doi.org/10.1016/j.ijpharm.2019.118531cc-by-nc-nd (c) Elsevier B.V., 2019https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1790092026-05-29T05:05:01Z
dc.title.none.fl_str_mv Cubic Liquid Crystalline Structures in diluted, concentrated and highly concentrated emulsions for topical application: influence on drug release and human skin permeation
title Cubic Liquid Crystalline Structures in diluted, concentrated and highly concentrated emulsions for topical application: influence on drug release and human skin permeation
spellingShingle Cubic Liquid Crystalline Structures in diluted, concentrated and highly concentrated emulsions for topical application: influence on drug release and human skin permeation
Arias Chousa, Eva María
Emulsions (Farmàcia)
Desenvolupament de medicaments
Absorció cutània
Pell
Emulsions (Pharmacy)
Drug development
Skin absorption
Skin
title_short Cubic Liquid Crystalline Structures in diluted, concentrated and highly concentrated emulsions for topical application: influence on drug release and human skin permeation
title_full Cubic Liquid Crystalline Structures in diluted, concentrated and highly concentrated emulsions for topical application: influence on drug release and human skin permeation
title_fullStr Cubic Liquid Crystalline Structures in diluted, concentrated and highly concentrated emulsions for topical application: influence on drug release and human skin permeation
title_full_unstemmed Cubic Liquid Crystalline Structures in diluted, concentrated and highly concentrated emulsions for topical application: influence on drug release and human skin permeation
title_sort Cubic Liquid Crystalline Structures in diluted, concentrated and highly concentrated emulsions for topical application: influence on drug release and human skin permeation
dc.creator.none.fl_str_mv Arias Chousa, Eva María
Guiró, Pere
Rodríguez-Abreu, Carlos
Solans Marsà, Conxita
Escribano Ferrer, Elvira
García Celma, Ma José
author Arias Chousa, Eva María
author_facet Arias Chousa, Eva María
Guiró, Pere
Rodríguez-Abreu, Carlos
Solans Marsà, Conxita
Escribano Ferrer, Elvira
García Celma, Ma José
author_role author
author2 Guiró, Pere
Rodríguez-Abreu, Carlos
Solans Marsà, Conxita
Escribano Ferrer, Elvira
García Celma, Ma José
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Emulsions (Farmàcia)
Desenvolupament de medicaments
Absorció cutània
Pell
Emulsions (Pharmacy)
Drug development
Skin absorption
Skin
topic Emulsions (Farmàcia)
Desenvolupament de medicaments
Absorció cutània
Pell
Emulsions (Pharmacy)
Drug development
Skin absorption
Skin
description Novel emulsions with a nanostructured continuous phase have been proposed as controlled drug delivery systems to enhance topical delivery of active ingredients avoiding systemic effects. In this study, oil-in-water (O/W) emulsions with two surfactant/water (S/W) weight ratios of 40:60 and 35:65, and oil concentrations of 10 wt% (diluted emulsion), 40 wt% (concentrated emulsion) and 85 wt% (highly concentrated emulsion) have been investigated to identify the presence of liquid crystalline structures and their influence on drug release and skin permeation. The emulsions have been characterized in terms of visual appearance, rheology and drug release. The presence of cubic liquid crystalline structures in emulsions with S/W 40:60 was confirmed by small angle X-ray scattering (SAXS). Rheology results showed a markedly different behaviour in emulsions with S/W 40:60 compared with nonstructured emulsions. A model drug, diclofenac sodium (DS) was successfully incorporated in the emulsions. DS release was studied with hydrophilic and lipophilic membranes, and the amount of DS in the receptor solution was significantly lower in the formulations containing cubic liquid structures. An in vitro skin permeation study with dermatomed human skin showed that emulsions with a nanostructured continuous phase are suitable formulations for topical delivery with DS retention in skin layers. The results indicate that the amount of drug retained in skin structures may be tuned by modification of liquid crystal concentration and emulsion structure.
publishDate 2019
dc.date.none.fl_str_mv 2019
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/179009
url https://hdl.handle.net/2445/179009
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1016/j.ijpharm.2019.118531
International Journal of Pharmaceutics, 2019, vol. 569, p. 1-9
https://doi.org/10.1016/j.ijpharm.2019.118531
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Elsevier B.V., 2019
https://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Elsevier B.V., 2019
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 9 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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