Novel nanostructured lipid carriers loading Apigenin for anterior segment ocular pathologies
This research was supported by the Spanish Ministry of Science and Innovation (PID2021-122187NB-C32) and a Llavors project (LLAV0004). EBS acknowledges FCT—Fundaçao para a Ciencia e a Tecnologia, I.P., in the scope of the project UIDP/04378/2020 and UIDB/04378/2020 of the Research Unit on Applied Mo...
| Autores: | , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de publicación: | 2024 |
| País: | España |
| Recursos: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:20.500.12328/4263 |
| Acesso em linha: | http://hdl.handle.net/20.500.12328/4263 https://dx.doi.org/10.1016/j.ijpharm.2024.124222 |
| Access Level: | acceso abierto |
| Palavra-chave: | Apigenina Portadors de lípids nanoestructurats Oli de rosa mosqueta Nanopartícules lipídiques Portadores de lípidos nanoestructurados Aceite de rosa mosqueta Nanopartículas lipídicas Apigenin Nanostructured lipid carriers Rosehip oil Lipid nanoparticles 61 |
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Novel nanostructured lipid carriers loading Apigenin for anterior segment ocular pathologiesBonilla-Vidal, L.Espina, M.García, M.L.Baldomà, L.Badia, J.González, J.A.Delgado, L.M.Gliszczyńska, A.Souto, E.B.Sánchez-López, E.ApigeninaPortadors de lípids nanoestructuratsOli de rosa mosquetaNanopartícules lipídiquesApigeninaPortadores de lípidos nanoestructuradosAceite de rosa mosquetaNanopartículas lipídicasApigeninNanostructured lipid carriersRosehip oilLipid nanoparticles61This research was supported by the Spanish Ministry of Science and Innovation (PID2021-122187NB-C32) and a Llavors project (LLAV0004). EBS acknowledges FCT—Fundaçao para a Ciencia e a Tecnologia, I.P., in the scope of the project UIDP/04378/2020 and UIDB/04378/2020 of the Research Unit on Applied Molecular Biosciences—UCIBIO and the project LA/P/0140/ 2020 of the Associate Laboratory Institute for Health and Bioeconomy—i4HB. E.S.-L. acknowledges the support of Grants for the Requalification of the Spanish University System.Dry eye disease (DED) is a chronic multifactorial disorder of the ocular surface caused by tear film dysfunction and constitutes one of the most common ocular conditions worldwide. However, its treatment remains unsatisfactory. While artificial tears are commonly used to moisturize the ocular surface, they do not address the underlying causes of DED. Apigenin (APG) is a natural product with anti-inflammatory properties, but its low solubility and bioavailability limit its efficacy. Therefore, a novel formulation of APG loaded into biodegradable and biocompatible nanoparticles (APG-NLC) was developed to overcome the restricted APG stability, improve its therapeutic efficacy, and prolong its retention time on the ocular surface by extending its release. APG-NLC optimization, characterization, biopharmaceutical properties and therapeutic efficacy were evaluated. The optimized APG-NLC exhibited an average particle size below 200 nm, a positive surface charge, and an encapsulation efficiency over 99 %. APG-NLC exhibited sustained release of APG, and stability studies demonstrated that the formulation retained its integrity for over 25 months. In vitro and in vivo ocular tolerance studies indicated that APG-NLC did not cause any irritation, rendering them suitable for ocular topical administration. Furthermore, APG-NLC showed non-toxicity in an epithelial corneal cell line and exhibited fast cell internalization. Therapeutic benefits were demonstrated using an in vivo model of DED, where APG-NLC effectively reversed DED by reducing ocular surface cellular damage and increasing tear volume. Anti-inflammatory assays in vivo also showcased its potential to treat and prevent ocular inflammation, particularly relevant in DED patients. Hence, APG-NLC represent a promising system for the treatment and prevention of DED and its associated inflammation.info:eu-repo/semantics/publishedVersionElsevier2024info:eu-repo/semantics/article14http://hdl.handle.net/20.500.12328/4263https://dx.doi.org/10.1016/j.ijpharm.2024.124222reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésInternational Journal of Pharmaceutics658info:eu-repo/grantAgreement/ES/MICINN/PID2021-122187NB-C32Under a Creative Commons licensehttps://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:20.500.12328/42632026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Novel nanostructured lipid carriers loading Apigenin for anterior segment ocular pathologies |
| title |
Novel nanostructured lipid carriers loading Apigenin for anterior segment ocular pathologies |
| spellingShingle |
Novel nanostructured lipid carriers loading Apigenin for anterior segment ocular pathologies Bonilla-Vidal, L. Apigenina Portadors de lípids nanoestructurats Oli de rosa mosqueta Nanopartícules lipídiques Apigenina Portadores de lípidos nanoestructurados Aceite de rosa mosqueta Nanopartículas lipídicas Apigenin Nanostructured lipid carriers Rosehip oil Lipid nanoparticles 61 |
| title_short |
Novel nanostructured lipid carriers loading Apigenin for anterior segment ocular pathologies |
| title_full |
Novel nanostructured lipid carriers loading Apigenin for anterior segment ocular pathologies |
| title_fullStr |
Novel nanostructured lipid carriers loading Apigenin for anterior segment ocular pathologies |
| title_full_unstemmed |
Novel nanostructured lipid carriers loading Apigenin for anterior segment ocular pathologies |
| title_sort |
Novel nanostructured lipid carriers loading Apigenin for anterior segment ocular pathologies |
| dc.creator.none.fl_str_mv |
Bonilla-Vidal, L. Espina, M. García, M.L. Baldomà, L. Badia, J. González, J.A. Delgado, L.M. Gliszczyńska, A. Souto, E.B. Sánchez-López, E. |
| author |
Bonilla-Vidal, L. |
| author_facet |
Bonilla-Vidal, L. Espina, M. García, M.L. Baldomà, L. Badia, J. González, J.A. Delgado, L.M. Gliszczyńska, A. Souto, E.B. Sánchez-López, E. |
| author_role |
author |
| author2 |
Espina, M. García, M.L. Baldomà, L. Badia, J. González, J.A. Delgado, L.M. Gliszczyńska, A. Souto, E.B. Sánchez-López, E. |
| author2_role |
author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Apigenina Portadors de lípids nanoestructurats Oli de rosa mosqueta Nanopartícules lipídiques Apigenina Portadores de lípidos nanoestructurados Aceite de rosa mosqueta Nanopartículas lipídicas Apigenin Nanostructured lipid carriers Rosehip oil Lipid nanoparticles 61 |
| topic |
Apigenina Portadors de lípids nanoestructurats Oli de rosa mosqueta Nanopartícules lipídiques Apigenina Portadores de lípidos nanoestructurados Aceite de rosa mosqueta Nanopartículas lipídicas Apigenin Nanostructured lipid carriers Rosehip oil Lipid nanoparticles 61 |
| description |
This research was supported by the Spanish Ministry of Science and Innovation (PID2021-122187NB-C32) and a Llavors project (LLAV0004). EBS acknowledges FCT—Fundaçao para a Ciencia e a Tecnologia, I.P., in the scope of the project UIDP/04378/2020 and UIDB/04378/2020 of the Research Unit on Applied Molecular Biosciences—UCIBIO and the project LA/P/0140/ 2020 of the Associate Laboratory Institute for Health and Bioeconomy—i4HB. E.S.-L. acknowledges the support of Grants for the Requalification of the Spanish University System. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/20.500.12328/4263 https://dx.doi.org/10.1016/j.ijpharm.2024.124222 |
| url |
http://hdl.handle.net/20.500.12328/4263 https://dx.doi.org/10.1016/j.ijpharm.2024.124222 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
International Journal of Pharmaceutics 658 info:eu-repo/grantAgreement/ES/MICINN/PID2021-122187NB-C32 |
| dc.rights.none.fl_str_mv |
Under a Creative Commons license https://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
Under a Creative Commons license https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
14 |
| dc.publisher.none.fl_str_mv |
Elsevier |
| publisher.none.fl_str_mv |
Elsevier |
| dc.source.none.fl_str_mv |
reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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