Podoplanin in inflammation and cancer

This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics.

Detalles Bibliográficos
Autores: Quintanilla, Miguel, Montero, Lucía, Renart, Jaime, Martín-Villar, Ester
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/188991
Acceso en línea:http://hdl.handle.net/10261/188991
Access Level:acceso abierto
Palabra clave:Podoplain
C-type lectin-like receptor 2 (CLEC-2)
Ezrin
Radixin
Inflammation
Thrombosis
id ES_e929cb8eb7de69f45a7cef2ee3c281fd
oai_identifier_str oai:digital.csic.es:10261/188991
network_acronym_str ES
network_name_str España
repository_id_str
spelling Podoplanin in inflammation and cancerQuintanilla, MiguelMontero, LucíaRenart, JaimeMartín-Villar, EsterPodoplainC-type lectin-like receptor 2 (CLEC-2)EzrinRadixinInflammationThrombosisThis article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics.Podoplanin is a small cell-surface mucin-like glycoprotein that plays a crucial role in the development of the alveoli, heart, and lymphatic vascular system. Emerging evidence indicates that it is also involved in the control of mammary stem-cell activity and biogenesis of platelets in the bone marrow, and exerts an important function in the immune response. Podoplanin expression is upregulated in different cell types, including fibroblasts, macrophages, T helper cells, and epithelial cells, during inflammation and cancer, where it plays important roles. Podoplanin is implicated in chronic inflammatory diseases, such as psoriasis, multiple sclerosis, and rheumatoid arthritis, promotes inflammation-driven and cancer-associated thrombosis, and stimulates cancer cell invasion and metastasis through a variety of strategies. To accomplish its biological functions, podoplanin must interact with other proteins located in the same cell or in neighbor cells. The binding of podoplanin to its ligands leads to modulation of signaling pathways that regulate proliferation, contractility, migration, epithelial⁻mesenchymal transition, and remodeling of the extracellular matrix. In this review, we describe the diverse roles of podoplanin in inflammation and cancer, depict the protein ligands of podoplanin identified so far, and discuss the mechanistic basis for the involvement of podoplanin in all these processes.The work developed in our laboratory was supported by the Spanish Ministry of Science, Innovation, and Universities (grant SAF2017-84183-R).Peer reviewedMultidisciplinary Digital Publishing InstituteAgencia Estatal de Investigación (España)Ministerio de Ciencia, Innovación y Universidades (España)Quintanilla, Miguel [0000-0002-2124-7657]Renart, Jaime [0000-0001-6620-3706]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201920192019info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/188991reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#SAF2017-84183-R/AEI/10.13039/501100011033info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/SAF2017-84183-Rhttps://doi.org/10.3390/ijms20030707Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1889912026-05-22T06:33:51Z
dc.title.none.fl_str_mv Podoplanin in inflammation and cancer
title Podoplanin in inflammation and cancer
spellingShingle Podoplanin in inflammation and cancer
Quintanilla, Miguel
Podoplain
C-type lectin-like receptor 2 (CLEC-2)
Ezrin
Radixin
Inflammation
Thrombosis
title_short Podoplanin in inflammation and cancer
title_full Podoplanin in inflammation and cancer
title_fullStr Podoplanin in inflammation and cancer
title_full_unstemmed Podoplanin in inflammation and cancer
title_sort Podoplanin in inflammation and cancer
dc.creator.none.fl_str_mv Quintanilla, Miguel
Montero, Lucía
Renart, Jaime
Martín-Villar, Ester
author Quintanilla, Miguel
author_facet Quintanilla, Miguel
Montero, Lucía
Renart, Jaime
Martín-Villar, Ester
author_role author
author2 Montero, Lucía
Renart, Jaime
Martín-Villar, Ester
author2_role author
author
author
dc.contributor.none.fl_str_mv Agencia Estatal de Investigación (España)
Ministerio de Ciencia, Innovación y Universidades (España)
Quintanilla, Miguel [0000-0002-2124-7657]
Renart, Jaime [0000-0001-6620-3706]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Podoplain
C-type lectin-like receptor 2 (CLEC-2)
Ezrin
Radixin
Inflammation
Thrombosis
topic Podoplain
C-type lectin-like receptor 2 (CLEC-2)
Ezrin
Radixin
Inflammation
Thrombosis
description This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/188991
url http://hdl.handle.net/10261/188991
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
SAF2017-84183-R/AEI/10.13039/501100011033
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/SAF2017-84183-R
https://doi.org/10.3390/ijms20030707
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869423004144893952
score 15,812429

Similares en LA Referencia