New Strategies for Stroke Therapy: Nanoencapsulated Neuroglobin

Stroke is a global health and socio-economic problem. However, no efficient preventive and/or palliative treatments have yet been found. Neuroglobin (Ngb) is an endogen neuroprotective protein, but it only exerts its beneficial action against stroke after increasing its basal levels. Therefore, its...

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Authors: Blanco-Ruiz, Santos, Martínez-Lara, Esther, Siles, Eva, Peinado-Herreros, María Ángeles
Format: article
Status:Published version
Publication Date:2022
Country:España
Institution:Universidad de Jaén
Repository:RUJA. Repositorio Institucional de la Producción Científica de la Universidad de Jaén
OAI Identifier:oai:ruja.ujaen.es:10953/1699
Online Access:https://doi.org/10.3390/pharmaceutics14081737
https://hdl.handle.net/10953/1699
Access Level:Open access
Keyword:Stroke
Neuroglobin
Nanoformulation
Ischemia
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spelling New Strategies for Stroke Therapy: Nanoencapsulated NeuroglobinBlanco-Ruiz, SantosMartínez-Lara, EstherSiles, EvaPeinado-Herreros, María ÁngelesStrokeNeuroglobinNanoformulationIschemiaStroke is a global health and socio-economic problem. However, no efficient preventive and/or palliative treatments have yet been found. Neuroglobin (Ngb) is an endogen neuroprotective protein, but it only exerts its beneficial action against stroke after increasing its basal levels. Therefore, its systemic administration appears to be an efficient therapy applicable to stroke and other neurodegenerative pathologies. Unfortunately, Ngb cannot cross the blood-brain barrier (BBB), making its direct pharmacological use unfeasible. Thus, the association of Ngb with a drug delivery system (DDS), such as nanoparticles (NPs), appears to be a good strategy for overcoming this handicap. NPs are a type of DDS which efficiently transport Ngb and increase its bioavailability in the infarcted area. Hence, we previously built hyaluronate NPS linked to Ngb (Ngb-NPs) as a therapeutic tool against stroke. This nanoformulation induced an improvement of the cerebral infarct prognosis. However, this innovative therapy is still in development, and a more in-depth study focusing on its long-lasting neuroprotectant and neuroregenerative capabilities is needed. In short, this review aims to update the state-of-the-art of stroke therapies based on Ngb, paying special attention to the use of nanotechnological drug-delivering tools.MDPI202420242022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.3390/pharmaceutics14081737https://hdl.handle.net/10953/1699reponame:RUJA. Repositorio Institucional de la Producción Científica de la Universidad de Jaéninstname:Universidad de JaénInglésPharmaceutics [2022];[14]:[1737]info:eu-repo/semantics/openAccessoai:ruja.ujaen.es:10953/16992026-06-24T12:41:07Z
dc.title.none.fl_str_mv New Strategies for Stroke Therapy: Nanoencapsulated Neuroglobin
title New Strategies for Stroke Therapy: Nanoencapsulated Neuroglobin
spellingShingle New Strategies for Stroke Therapy: Nanoencapsulated Neuroglobin
Blanco-Ruiz, Santos
Stroke
Neuroglobin
Nanoformulation
Ischemia
title_short New Strategies for Stroke Therapy: Nanoencapsulated Neuroglobin
title_full New Strategies for Stroke Therapy: Nanoencapsulated Neuroglobin
title_fullStr New Strategies for Stroke Therapy: Nanoencapsulated Neuroglobin
title_full_unstemmed New Strategies for Stroke Therapy: Nanoencapsulated Neuroglobin
title_sort New Strategies for Stroke Therapy: Nanoencapsulated Neuroglobin
dc.creator.none.fl_str_mv Blanco-Ruiz, Santos
Martínez-Lara, Esther
Siles, Eva
Peinado-Herreros, María Ángeles
author Blanco-Ruiz, Santos
author_facet Blanco-Ruiz, Santos
Martínez-Lara, Esther
Siles, Eva
Peinado-Herreros, María Ángeles
author_role author
author2 Martínez-Lara, Esther
Siles, Eva
Peinado-Herreros, María Ángeles
author2_role author
author
author
dc.subject.none.fl_str_mv Stroke
Neuroglobin
Nanoformulation
Ischemia
topic Stroke
Neuroglobin
Nanoformulation
Ischemia
description Stroke is a global health and socio-economic problem. However, no efficient preventive and/or palliative treatments have yet been found. Neuroglobin (Ngb) is an endogen neuroprotective protein, but it only exerts its beneficial action against stroke after increasing its basal levels. Therefore, its systemic administration appears to be an efficient therapy applicable to stroke and other neurodegenerative pathologies. Unfortunately, Ngb cannot cross the blood-brain barrier (BBB), making its direct pharmacological use unfeasible. Thus, the association of Ngb with a drug delivery system (DDS), such as nanoparticles (NPs), appears to be a good strategy for overcoming this handicap. NPs are a type of DDS which efficiently transport Ngb and increase its bioavailability in the infarcted area. Hence, we previously built hyaluronate NPS linked to Ngb (Ngb-NPs) as a therapeutic tool against stroke. This nanoformulation induced an improvement of the cerebral infarct prognosis. However, this innovative therapy is still in development, and a more in-depth study focusing on its long-lasting neuroprotectant and neuroregenerative capabilities is needed. In short, this review aims to update the state-of-the-art of stroke therapies based on Ngb, paying special attention to the use of nanotechnological drug-delivering tools.
publishDate 2022
dc.date.none.fl_str_mv 2022
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.3390/pharmaceutics14081737
https://hdl.handle.net/10953/1699
url https://doi.org/10.3390/pharmaceutics14081737
https://hdl.handle.net/10953/1699
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Pharmaceutics [2022];[14]:[1737]
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:RUJA. Repositorio Institucional de la Producción Científica de la Universidad de Jaén
instname:Universidad de Jaén
instname_str Universidad de Jaén
reponame_str RUJA. Repositorio Institucional de la Producción Científica de la Universidad de Jaén
collection RUJA. Repositorio Institucional de la Producción Científica de la Universidad de Jaén
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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